Search results for " CD"
showing 10 items of 587 documents
Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins
2000
Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system. In this study we investigated the effects of various prostaglandins (PG) on the stimulatory capacity of DC. DC were generated from peripheral progenitor cells in the presence of IL-4 and GM-CSF and stimulated with IL-1, IL-6 and TNF-alpha on day 7. Simultaneously, PG (PGD(2), PGE(1), PGE(2), PGF(2 alpha), PGI(2)) were added at various concentrations (10(-5) to 10(-9) M) on day 7. In all experiments, PGE(2) had the most potent influence on the maturation of the DC, followed by other PG in the order PGE(1) > PGD(2) > PGF(2 alpha) > PGI(2). In addition, the expression of the surface molecules CD40, CD54, CD…
Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers
2021
Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compared to those with normal immunoglobulin levels and, therefore, there is a rational explanation to administer intravenous IgM-enriched immunoglobulins to septic patients in ICU. Aim of this study is to evaluate the effectiveness of intravenous IgM-enriched immunoglobulins in decreasing several sepsis biomarker concentrations. 26 sepsis patients were enrolled in this observational cohort study and Nitric Oxide, Endocan, Pentraxin and presepsin serum levels were measured during their first 3 days of ICU stay. The use of intravenous IgM-enriched immunoglobulins did not influence the temporal evol…
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
Rare localization of low grade fibromyxoid sarcoma to the nail region.
2005
Microwave-assisted synthesis of semiconductor nanoparticles in water/oil microemulsion
2005
Stable CdS and ZnS nanoparticles with exalted luminescence properties have been obtained in water/sodium bis (2-ethylhexyl) sulfosuccinate (AOT)/n-heptane microemulsion using microwave in order to take away selectively water molecules from microemulsion system. The nanoparticles synthesis was performed using a microwave exposure set-up opportunely assembled that allows irradiating the reactor with microwave of 2.45 GHz maintaining constant the temperature. The nanoparticles growth kinetics, as a function of irradiation time, was performed by means of UV-Vis spectroscopy. Information about the structural changes that microemulsion undergoes when irradiated with microwave was obtained by mean…
Suomen CDG-mallia kehittämässä : oppilaiden kokemukset oppijakeskeisestä liikunnanopetusinterventiosta
2015
Tässä tutkimuksessa tarkoituksenamme oli selvittää, eroavatko oppilaslähtöiseen liikunnanopetusinterventioon osallistuneiden alakoulun oppilaiden kokemukset koetusta autonomiasta, sekä liikuntaa opettavan luokanopettajan demokraattisesta käyttäytymisestä ja opettajan tarjoamasta sosiaalisesta tuesta, kontrollikoulun oppilaiden kokemuksiin verrattuna. Halusimme myös selvittää, erosivatko interventioon osallistuneiden tyttöjen ja poikien kokemukset toisistaan. Tutkimusaineisto koostui Liikuntatunnit kaikille aktiiviseksi - CDG-malli opetuksen tukena - hankkeesta, joka toteutettiin marraskuun 2011 ja maaliskuun 2013 välisenä aikana. Interventio pohjautui australialaiseen Quayn ja Petersin (200…
Suomen CDG-malli : oppilaiden kokemukset oppijakeskeisestä liikunnanopetusinterventiosta
2015
Tässä tutkimuksessa tarkoituksenamme oli selvittää, eroavatko oppilaslähtöiseen liikunnanopetusinterventioon osallistuneiden alakoululaisten kokemukset koetusta autonomiasta sekä liikuntaa opettavan luokanopettajan demokraattisesta käyttäytymisestä ja hänen tarjoamastaan sosiaalisesta tuesta verrattuna kontrollikoulun oppilaiden kokemuksiin. Halusimme myös selvittää, erosivatko interventioon osallistuneiden tyttöjen ja poikien kokemukset toisistaan. Tutkimuksemme oli Jyväskylän yliopiston opettajankoulutuslaitoksen ja liikuntakasvatuksen laitoksen yhteistyönä toteuttaman Liikuntatunnit kaikille aktiiviseksi – CDG-malli opetuksen tukena -hankkeen osatutkimus, joka toteutettiin marraskuun 201…
ATTIVITÀ ANTIPROLIFERATIVA DI UN DERIVATO POLICICLICO CON STRUTTURA COMPLESSA
2014
Un nuovo derivato policiclico glicosilato è stato ottenuto partendo dal derivato policiclico iodurato, utilizzando la reazione di Sonogashira.Il composto glicosilato saggiato presso l’NCI è risultato attivo su tutte le 60 linee cellulari tumorali del panel, risultando più attivo degli altri composti policiclici precedentemente saggiati. Il composto induce l’arresto del ciclo cellulare in fase G2/M nella linea cellulare MDA-MB231, fa diminuire i livelli di ciclina B1e Cdc-2 mentre produce un aumento dell’inibitore p21WAF1, una chinasi ciclino-dipendente.
Assessment of Sentinel-2-MSI Atmospheric Correction Processors and In Situ Spectrometry Waters Quality Algorithms
2022
The validation of algorithms developed from in situ reflectance to estimate water quality variables has the challenge of atmospheric correction (AC) when applied to satellite images. Estimating water quality variables from satellite images requires an accurate estimation of remote sensing reflectances (Rrs) which vary according to the AC applied. Validation processes for both Rrs and water quality algorithms were carried out, relating the in situ Rrs (convoluted to Sentinel-2-MSI spectral response function) with the satellite Rrs coming from different ACs (C2RCC, C2X, C2XC, and Polymer), and also relating the in situ water quality variable data with estimated water quality variable values, …