Search results for " Capacity"
showing 10 items of 902 documents
A phase II/III clinical study of enzyme replacement therapy with idursulfase in mucopolysaccharidosis II (Hunter syndrome)
2006
Purpose: To evaluate the safety and efficacy of recombinant human iduronate-2-sulfatase (idursulfase) in the treatment of mucopolysaccharidosis II. Methods: Ninety-six mucopolysaccharidosis II patients between 5 and 31 years of age were enrolled in a double-blind, placebo-controlled trial. Patients were randomized to placebo infusions, weekly idursulfase (0.5 mg/kg) infusions or every-other-week infusions of idursulfase (0.5 mg/kg). Efficacy was evaluated using a composite endpoint consisting of distance walked in 6 minutes and the percentage of predicted forced vital capacity based on the sum of the ranks of change from baseline. Results: Patients in the weekly and every-other-week idursul…
Determinants of bronchial hyperresponsiveness in subjects with rhinitis.
2005
Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) ≥ 80% of the predicted value. In all subjects a skin prick test (SPT) was performed, a determination of total serum IgE and an eosinophils count in the blood. Of the 410 subjects we found that 161 (39.3%) exhibited a methacholine PD20 of 800 mg or less (Group A), whereas 249 (60.7%) had a methacholine PD20 more of 800 mg (Group B). Despite the matched mean values for FEV…
The relationship between age and fitness profiles in elite male ice hockey players
2021
Background: The present study investigated relationships between age, body composition and performance in elite male ice hockey players.Methods: 199 players performed off-ice tests (countermovement jump height (CMJ) and body composition) and on-ice tests (5-10-5 Pro Agility test, 30-m sprint test and the maximal Yo-Yo Intermittent Recovery Ice Hockey test (Yo-Yo IR1-IHMAX) for assessment of aerobic capacity.Results: No overall correlations between age and performance were present except small-moderate positive associations between age and body-and muscle mass (r=0.24-0.30, ≤0.05). The youngest age group (YOU; 18-21 years) were 4-9% lighter than all other age groups and possessed 7% less mus…
Effect of mental fatigue on speed–accuracy trade-off
2015
International audience; The aim of this study was to investigate the effects of mental fatigue on the duration of actual and imagined goal-directed arm movements involving speed-accuracy trade-off. Ten participants performed actual and imagined point-to-point arm movements as accurately and as fast as possible, before and after a 90-min sustained cognitive task inducing mental fatigue, and before and after viewing a neutral control task (documentary movie) that did not induce mental fatigue. Target width and center-to-center target distance were varied, resulting in five different indexes of difficulty. Prior to mental fatigue, actual and imagined movement duration increased with the diffic…
Altered oxidative stress in overtrained athletes
2010
The purpose of the present study was to examine the relationship between oxidative stress and overtraining syndrome. Indicators of oxidative stress (plasma protein carbonyls, nitrotyrosine, and malondialdehyde) and antioxidant status (oxygen radical absorbance capacity) were measured in severely overtrained (two women, five men) and control athletes (five women, five men). Samples were collected from both groups at baseline (i.e. in the overtraining state of overtrained athletes) and after 6 months of recovery, both at rest and immediately after an exercise test to volitional exhaustion. At baseline, overtrained athletes had higher plasma protein carbonyls at rest than controls (mean differ…
Maximal Aerobic Power Characteristics of Male Professional Soccer Players, 1989–2012
2013
Purpose:The purpose of this investigation was to quantify maximal aerobic power (VO2max) in soccer as a function of performance level, position, age, and time of season. In addition, the authors examined the evolution of VO2max among professional players over a 23-y period.Methods:1545 male soccer players (22 ± 4 y, 76 ± 8 kg, 181 ± 6 cm) were tested for VO2max at the Norwegian Olympic Training Center between 1989 and 2012.Results:No differences in VO2max were observed among national-team players, 1st- and 2nd-division players, and juniors. Midfielders had higher VO2max than defenders, forwards, and goalkeepers (P < .05). Players <18 y of age had ~3% higher VO2max than 23- to 26-y-old…
Relationships between maximal oxygen uptake and endothelial function in healthy male adults: a preliminary study
2010
Aerobic capacity, as indicated by maximal oxygen uptake (VO(2) max) has an important role in contrasting the traditional cardiovascular risk factors and preventing cardiovascular morbidity and mortality. It is known that endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery, is strictly linked to atherogenesis and cardiovascular risk. However, the relationship between VO(2) max and FMD has not been fully investigated especially in healthy non-obese subjects. This preliminary study cross-sectionally investigated the relationship between VO(2) max and FMD in 22 non-obese, healthy sedentary male subjects. Dividing the cohort in two subgroups of 11 subjects each …
Physical fitness, BMI and sickness absence in male military personnel
2008
Background In modern society, decreased physical activity and/or changes in quality and quantity of nutritional intake contribute to obesity and lifestyle diseases that result in economic costs, both to society and to individuals. Aims To measure physical fitness and body mass index (BMI) and to assess their association with sickness absence in male soldiers. Methods Data regarding BMI and physical fitness (aerobic endurance and muscle fitness) were collected for male Finnish military personnel and combined with sickness absence data collected in the year 2004. The duration and costs of sickness absence were obtained from the personnel administration. Results A total of 7179 male military p…
Serum hormones in soldiers after basic training: effect of added strength or endurance regimens.
2009
Introduction Military personnel are often exposed to training programs and operational situations that involve multiple stressors such as caloric deficit, sleep deprivation, and prolonged physical effort, which may disturb body homeostasis, as indicated by hormonal responses.Therefore, we investigated the effects of three training regimens on serum basal hormone concentrations before and after the 8-wk basic training (BT) period, and whether possible changes in serum basal concentrations are related to changes in endurance and strength performance. Methods Serum hormone levels were measured in 3 groups of 24 male military conscripts before and after 3 different types of training programs: n…
Hybrid Functional Electrical Stimulation Exercise Training Alters the Relationship Between Spinal Cord Injury Level and Aerobic Capacity
2014
Objective To test the hypothesis that hybrid functional electrical stimulation (FES) row training would improve aerobic capacity but that it would remain strongly linked to level of spinal cord lesion because of limited maximal ventilation. Design Longitudinal before–after trial of 6 months of FES row training. Setting Exercise for persons with disabilities program in a hospitaL. Participants Volunteers (N=14; age range, 21–63y) with complete spinal cord injury (SCI) (T3-11) who are >2 years postinjury. Intervention Six months of FES row training preceded by a variable period of FES strength training. Main Outcome Measures Peak aerobic capacity and peak exercise ventilation before and after…