Search results for " Codon"

IAP et Rho : enfin connectées

2014

231 m/s n° 3, vol. 30, mars 2014 DOI : 10.1051/medsci/20143003003 5. Apcher S, Millot G, Daskalogianni C, et al. Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway. Proc Natl Acad Sci USA 2013 ; 110 : 17951-6. 6. de Turris V, Nicholson P, Orozco RZ, et al. Cotranscriptional effect of a premature termination codon revealed by live-cell imaging. RNA 2011 ; 17 : 2094-107. 7. Iborra FJ, Jackson DA, Cook PR. Coupled transcription and translation within nuclei of mammalian cells. Science 2001 ; 293 : 1139-42. 8. David A, Dolan BP, Hickman HD, et al. Nuclear translation visualized by ribosome-bound nascent chain puromycylation. J Cell Biol 201…

Structural and evolutionary analysis of the copia-like elements in the Arabidopsis thaliana genome.

2001

The analysis of 460 kb of genomic sequence of Arabidopsis thaliana chromosome III allowed us to identify two new transposable elements named AtC1 and AtC2. AtC1 shows identical long terminal repeats (LTRs) and all the structural features characteristic of the copia-like active elements. AtC2 is also a full copia-like element, but a putative stop codon in the open reading frame (ORF) would produce a truncated protein. In order to identify the copia-like fraction of the A. thaliana genome, a careful computer-based analysis of the available sequences (which correspond to 92% of the genome) was performed. Approximately 300 nonredundant copia-like sequences homologous to AtC1 and AtC2 were detec…

Allium therinanthum (Amaryllidaceae), a new species from Israel

2014

Allium therinanthum, a new species of A. sect. Codonoprasum, is described and illustrated from southern Mt. Hermon (Israel). It is a late-flowering diploid species (2n = 16), growing on calcareous substrates of the mountain belt. It is a narrowly distributed geophyte, showing morphological relationships mainly with A. tardiflorum, a typical autumnal species also occurring in Israel within the pinewoods of Mt. Carmel. The morphology, karyology, leaf anatomy, ecology, conservation status and taxonomical relations are examined for both species. A taxonomic comparison with the most allied late flowering species of the sect. Codonoprasum is provided.

Retrovirus infection and aging: Increase in UAG suppressor tRNA expression in aged mice.

1994

Summary The effect of aging on expression of a natural glutamine suppressor tRNA (tRNA Gln(UmUG) ) was studied in different tissues of mice; this tRNA recognizes UAG and inserts glutamine at the site of the termination codon. The level of tRNA Gln(UmUG) was found to be strongly increased in aged mice, compared to newborn and mature animals. An elevated expression of tRNA Gln(UmUG) has also been found in retrovirus-infected cells; in Moloney virus-infected cells the suppressor tRNA allows to read-through the UAG codon within the retroviral protease gene. We suggest that the increase in the level of tRNA Gln(UmUG) may influence retroviral gene expression with age.

Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons

2020

Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo

Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codon…

2015

Molecular Approaches Fighting Nonsense

2021

Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...]

Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense

Allium aetnense (Amaryllidaceae), a new species from Sicily.

2013

A new species from Mt Etna (Sicily), Allium aetenense of A. sect. Codonoprasum, is described and illustrated. It is a diploid species (2n = 16) that grows on basaltic rocks in the mountain belt and shows close relationships with A. tenuiflorum of the Italian peninsula. Its morphology, karyology, leaf anatomy, seed coat microsculpturing, ecology and taxonomic position are examined.

A new autumn-flowering species of Allium (Alliaceae) from Croatia

2009

Here we describe Allium telmatum Bogdanovic, Brullo, Giusso & Salmeri, a new species of Allium sect. Codonoprasum from North Dalmatia (Croatia). Its chromosome number (2n = 32), karyotype, leaf anatomy, ecology and taxonomical relationships are examined. Several features, such as phenology (flowering in autumn), occurrence in coastal salt marshes, tetraploid chromosome number, and morphology, indicate that it is most closely related to the Tyrrhenian species Allium savii. On the basis of our herbarium survey, we present here a distribution map of the autumn-flowering species of Allium sect. Codonoprasum in the Mediterranean area.