Search results for " Common"
showing 10 items of 343 documents
Caraibi: un "archipel inachevé"
2018
L’etichetta “Letterature franco-caraibica” utilizzata, per convenzione, dalla critica per indicare unitariamente la produzione letteraria in lingua francese della regione centrale del Continente americano è assai impropria. La regione dei Caraibi abbraccia, infatti, sia alcune delle isole dell’arcipelago delle Piccole Antille (Martinica, Guadalupa), sia l’isola di Haïti, che fa parte delle Grandi Antille, che la Guiana incastonata sulla costa orientale dell’America meridionale. Pur nella diversità dei movimenti ideologici e degli avvenimenti storici che si sono succeduti nella regione, le opere letterarie degli scrittori caraibici francofoni, nel loro insieme, hanno oscillato, e continuano …
Ambiente e diritto penale: brevi riflessioni fra le modifiche agli artt.9 e 41 Cost. e le prospettive di riforma in ambito internazionale
2023
l contributo analizza l’impatto che il recente inserimento dell’ambiente in Costituzione può dispiegare in ambito penale, tanto rispetto all’ambiente quale oggetto della tutela penale, quanto sul versante della selezione dei modelli di illecito, soffermandosi in particolare sul problema delle possibili ricadute penalistiche del nuovo vincolo di solidarietà ecologica di tipo intergenerazionale. Seguendo il fil rouge del bene giuridico, la seconda parte del saggio ricostruisce invece i punti critici e le prospettive di sviluppo del diritto penale ambientale internazionale, alla luce della nozione di ambiente quale bene giuridico comune ed universale.
Reimparare il comune: A teatro dopo il 1989
2020
L'articolo coglie l’invito a recarsi a teatro con una domanda in mente: in che misura la data ‘spartiacque’ del 1989 ha influenzato, cambiato, sfidato la creazione scenica in Europa? Si tratterà di vedere in che misura la scossa dell’evento 1989 (di cui non è detto che coincida del tutto con la data 1989) permise alle arti sceniche di anticipare, nel paradossale ‘in più’ di una perdita di parola (che rintracceremo in alcuni lavori teatrali dell’epoca), una profonda trasformazione di cui viviamo oggi gli effetti.
A basic analysis toolkit for biological sequences
2007
This paper presents a software library, nicknamed BATS, for some basic sequence analysis tasks. Namely, local alignments, via approximate string matching, and global alignments, via longest common subsequence and alignments with affine and concave gap cost functions. Moreover, it also supports filtering operations to select strings from a set and establish their statistical significance, via z-score computation. None of the algorithms is new, but although they are generally regarded as fundamental for sequence analysis, they have not been implemented in a single and consistent software package, as we do here. Therefore, our main contribution is to fill this gap between algorithmic theory an…
Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor
2004
The cytokine erythropoietin (Epo) is tissue-protective in preclinical models of ischemic, traumatic, toxic, and inflammatory injuries. We have recently characterized Epo derivatives that do not bind to the Epo receptor (EpoR) yet are tissue-protective. For example, carbamylated Epo (CEpo) does not stimulate erythropoiesis, yet it prevents tissue injury in a wide variety ofin vivoandin vitromodels. These observations suggest that another receptor is responsible for the tissue-protective actions of Epo. Notably, prior investigation suggests that EpoR physically interacts with the common β receptor (βcR), the signal-transducing subunit shared by the granulocyte-macrophage colony stimulating fa…
The Effect of Different High-Intensity Periodization Models on Endurance Adaptations
2016
Purpose: This study aimed to compare the effects of three different high-intensity training (HIT) models, balanced for total load but differing in training plan progression, on endurance adaptations. Methods: Sixty-three cyclists (peak oxygen uptake (V˙O2peak) 61.3 ± 5.8 mL·kg−1·min−1) were randomized to three training groups and instructed to follow a 12-wk training program consisting of 24 interval sessions, a high volume of low-intensity training, and laboratory testing. The increasing HIT group (n = 23) performed interval training as 4 × 16 min in weeks 1–4, 4 × 8 min in weeks 5–8, and 4 × 4 min in weeks 9–12. The decreasing HIT group (n = 20) performed interval sessions in the opposite…
Comparison of two different approaches for harmonic distortion sources assessment
2021
The paper focuses the attention on the comparison of two approaches for power quality assessment in the electric grid. Both approaches are suitable for investigating the harmonic pollution source and discovering if the harmonic source comes from the customer or the utility grid. The two approaches have the same purpose but they are deeply different. The first approach is based on the knowledge of the customer and utility equivalent impedance while the second is based on single point measurement at point of common coupling PCC. In this paper, the advantages and drawbacks of the two approaches are investigated also supported by a case study.
Traditional Medicine with Plants Present and Past
2014
Copyright: © 2014 Efferth T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Traditional Medicine with Plants – Present and Past Thomas Efferth1* and Henry Johannes Greten2,3 1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany 2Abel Salazar Biomedical Sciences Institute, University of Porto, Portugal 3Heidelberg School of Chinese Medicine, Heidelberg, Germany
Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells.
2011
We have identified a novel interleukin (IL)-7-responsive T cell population [forkhead box P3 (FoxP3(+) ) CD4(+) CD25(+) CD127(+) ] that is comparably functionally suppressive to conventional FoxP3(+) CD4(+) CD25(+) regulatory T cells (T(regs) ). Although IL-2 is the most critical cytokine for thymic development of FoxP3(+) T(regs) , in the periphery other cytokines can be compensatory. CD25(+) CD127(+) T cells treated with IL-7 phenotypically 'matured' into the known 'classical' FoxP3(+) CD4(+) CD25(high) CD127(-) FoxP3(+) T(regs) . In freshly isolated splenocytes, the highest level of FoxP3 expression was found in CD127(+) CD25(+) T cells when compared with CD127(-) CD25(+) or CD127(+) CD25…
In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.
2010
The potent anti-tumour activities of gamma delta T cells have prompted the development of protocols in which gamma delta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a V gamma 9V delta 2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of V gamma 9V delta 2 T …