Search results for " Complete"
showing 7 items of 97 documents
Formaciones sociales y opresión en Marx
2018
The text explains the difference between Marx?s concept of «oppression» and others as «coercion» by Durkheim or «domination» by Weber. The article then establishes, in a methodical way, the centrality of a passage from Capital, in which three different theories on «oppression» appear. It?s explained that two of them are rather a philosophical antinomy. The other, relative to the heteronomy of social time, can be completed by defining the heteronomy of social space, which gives it analytical virtuality. Some examples are given.
Apoptotic-like Leishmania exploit the host´s autophagy machinery to reduce T-cell-mediated parasite elimination
2015
Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the exact mechanism of how apoptosis in unicellular organisms may support infectivity remains unclear. Therefore we investigated the fate of apoptotic-like Leishmania parasites in human host macrophages. Our data showed--in contrast to viable parasites--that apoptotic-like parasites enter an LC3(+), autophagy-like compartment. The compartm…
Impact of Cumulative Dose of Carfilzomib in Combination with Lenalidomide and Dexamethasone in Relapsed Refractory Myeloma Patients: A Retrospective …
2018
Abstract Background: Triplet-based lenalidomide plus dexamethasone (Rd) combinations have become the new standard of care for early relapse and refractory multiple myeloma (RRMM). Carfilzomib is a novel selective proteasome inhibitor (PI) with high efficacy in RRMM. The ASPIRE phase 3 trial showed the superiority of carfilzomib-based triplet (KRd compared to Rd), leading to approval of K for RRMM. However, little is known about safety and efficacy of KRd outside a clinical trial context. Experimental design and aims: In 11 Sicilian Centers belonging to the Sicilian Myeloma Network, from November 2016, when KRd regimen was approved in Italy, to June 2018, 103 consecutive RRMM patients (previ…
Modal Consequence Relations Extending S4.3: An Application of Projective Unification
2016
We characterize all finitary consequence relations over $\mathbf{S4.3}$ , both syntactically, by exhibiting so-called (admissible) passive rules that extend the given logic, and semantically, by providing suitable strongly adequate classes of algebras. This is achieved by applying an earlier result stating that a modal logic $L$ extending $\mathbf{S4}$ has projective unification if and only if $L$ contains $\mathbf{S4.3}$ . In particular, we show that these consequence relations enjoy the strong finite model property, and are finitely based. In this way, we extend the known results by Bull and Fine, from logics, to consequence relations. We also show that the lattice of consequence relation…
Predictive models in assessment of macroinvertebrates in boreal rivers
2009
Jukka Aroviita tutki väitöskirjassaan jokien ja purojen biologisen tilan mittaamismenetelmiä. Aroviita osoitti, että ihmistoiminnan aiheuttamat biologiset muutokset voivat jäädä havaitsematta, jos eliöyhteisöjen luonnollista taustavaihtelua ei oteta kunnolla huomioon.- Tällöin vesistöjen saatetaan arvioida olevan paremmassa kunnossa kuin ne todellisuudessa ovatkaan. Muutosten tunnistamistarkkuuden tulisi olla mahdollisimman hyvä, sillä tila-arvioilla on myös juridisesti määräytyviä yhteiskunnallisia ja taloudellisia seuraamuksia, Aroviita toteaa. Vielä 1990-luvulla järvien ja jokien tilaa arvioitiin suurelta osin ihmisen näkökulmasta ja veden kemian perusteella. Nykylainsäädäntö edellyttää …
Sensitivity of bipartite network analyses to incomplete sampling and taxonomic uncertainty
2023
Bipartite network analysis is a powerful tool to study the processes structuring interactions in ecological communities. In applying the method, it is assumed that the sampled interactions provide an accurate representation of the actual community. However, acquiring a representative sample may be difficult as not all species are equally abundant or easily identifiable. Two potential sampling issues can compromise the conclusions of bipartite network analyses: failure to capture the full range of interactions (sampling completeness) and use of a taxonomic level higher than species to evaluate the network (taxonomic resolution). We asked how commonly used descriptors of bipartite antagonisti…
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…