Search results for " Computer"

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

In Pursuit of Measuring Pre-reflective Music Listening Experiences

2022

While the diverse effects and uses of music and sound have been extensively documented within music psychology, relatively little attention has been paid to the process and experience of listening itself. Previous literature have, however, considered different ways of attending to sounds via the concept of listening modes, which highlights the different ways and strategies through which listeners intentionally orientate themselves to the activity of listening and creating the experiential meaning of the sound. In this paper, we continue on these lines by focusing on the very basic attentional dispositions for listening that often remain unconscious. As op posed to more deliberate and intent…

Estimation of the Time-Variant Velocity of a Single Walking Person in Two-Dimensional Non-Stationary Indoor Environments Using Radio-Frequency Techni…

2020

Accurate estimation of the time-variant (TV) velocity of moving persons/objects in indoor spaces is of crucial importance for numerous wireless indoor applications. This article introduces a novel iterative procedure to estimate the TV velocity, i.e., TV speed and TV angle-of-motion (AOM), of a single moving person in 2D indoor environments by using radio-frequency (RF) techniques. The indoor area is equipped with a distributed 2 × 2 multiple-input multiple-output (MIMO) system. The proposed method is divided into two parts. In the first part, we estimate the path gains and the instantaneous Doppler frequencies by fitting the exact spectrograms of the complex channel gains of a 2D no…

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

From conceptualization to constructions in Finnish as an L2 : a case study

2017

AbstractThis study traces the individual learning trajectories of an adult beginner L2 Finnish learner in expressing the extralinguistic concept of evaluation from a dynamic usage-based perspective. Our results provide support for the view of learner language as a dynamic system in which patterns wax and wane and in which a change in one component has the potential to affect the whole system. In the early stages of learning there was a strong preference to use lexical verbs first, and then adjectives. The study also shows that variability plays a role. Finally, the study confirms that the learning of L2 constructions is in some cases item based. However, another highly frequent and superfic…

Skeleton-Based Multiview Reconstruction

2016

International audience; The advantage of skeleton-based 3D reconstruction is to completely generate a single 3D object from well chosen views. Having numerous views is necessary for a reliable reconstruction but projections of skeletons lead to different topologies. We reconstruct 3D objects with curved medial axis (whose topology is a tree) from the perspective skeletons on an arbitrary number of calibrated acquisitions. The main contribution is to estimate the 3D skeleton, from multiple images: its topology is chosen as the closest to those of the perspective skeletons on the set of images, which means that the number of topology changes to map the 3D skeleton topology to topologies on im…

Gender and Toxic Meritocracy in Competitive Overwatch: Case “Ellie”

2022

AbstractThis chapter examines toxic meritocracy in relation to gender in competitive Overwatch, asking how gender affects a player’s opportunities for engagement in that scene. It analyzes online news stories and community discussions concerning “Ellie” – a fabricated competitive woman gamer created as a “social experiment” by a man player. The confluences between gender and toxic meritocracy become visible in the assumption there must be an experienced man gamer behind the battletag, the gender-based harassment targeted at Ellie, and the reflections on the importance of setting an example as the first team taking a woman player for Contenders. The analysis shows that despite a strong belie…

La dimensione cognitiva nella traduzione assistita da computer e nella traduzione automatica

La tesi sviluppa una riflessione critica sull’utilizzo delle tecnologie per la traduzione, cercando di comprendere come esse siano state sviluppate a partire da rappresentazioni diverse del processo traduttivo umano, e di identificare le ricadute positive e negative che esse producono sul processo di traduzione, sia a livello pratico sia più profondamente, ovvero sulle dinamiche cognitive che lo caratterizzano e sul nuovo modo in cui il traduttore percepisce gli strumenti stessi, il testo e persino il proprio lavoro. The work presents the wide range of translation technologies today available, trying to shed light on the different representations of the human translation process that they t…

Dealing with the right of way in advanced traffic simulation. A characterization of drivers' behaviours in a multi-agent approach

2017

International audience; With the emergence of ADAS and autonomous vehicle, the need of simulation software to test advanced systems and models is unavoidable. The objective of this work is to characterize, in a multi-agent approach, the traffic vehicles behaviours, and to model them in a versatile traffic simulator, serving as a testing tool for integration in the traffic module of the SCANeR Studio T M simulation software. The algorithm will bring more natural interactions between vehicles in simulation and allow the emergence of new relevant situations for autonomous vehicles, observable in real, such as collision risk situations or even accidents, which have for now to be scripted in sce…

AI Ethics in Industry: A Research Framework

2019

Artificial Intelligence (AI) systems exert a growing influence on our society. As they become more ubiquitous, their potential negative impacts also become evident through various real-world incidents. Following such early incidents, academic and public discussion on AI ethics has highlighted the need for implementing ethics in AI system development. However, little currently exists in the way of frameworks for understanding the practical implementation of AI ethics. In this paper, we discuss a research framework for implementing AI ethics in industrial settings. The framework presents a starting point for empirical studies into AI ethics but is still being developed further based on its pr…