Search results for " Conjugate"
showing 10 items of 111 documents
A unified approach to projective lattice geometries
1992
The interest in pursuing projective geometry on modules has led to several lattice theoretic generalizations of the classical synthetic concept of projective geometry on vector spaces.
Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.
2014
The term amyloidosis describes neurological diseases where an abnormal protein is misfolded and accumulated as deposits in organs and tissues, known as amyloid, disrupting their normal function. In the most common familial amyloid polyneuropathy (FAP), transthyretin (TTR) displays this role primarily affecting the peripheral nervous system (PNS). Advanced stages of this inherited rare amyloidosis, present as fibril deposits that are responsible for disease progression. In order to stop disease progression, herein we designed an efficient family of nanoconjugates as fibril disrupters. These polymer conjugates are based on doxycycline (doxy), already in phase II trials for Alzheimer's disease…
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor
2013
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the aim to improve EphA2 receptor inhibition. Structure-activity relationships indicate that conjugation of cholanic acid with linear amino acids of small size leads to effective EphA2 antagonists whereas …
Firing characteristics of vestibular nuclei neurons in the alert monkey after bilateral vestibular neurectomy
1992
After destruction of the peripheral vestibular system which is not activated by moving large-field visual stimulation, not only labyrinthine-ocular reflexes but also optokinetic-ocular responses related to the "velocity storage" mechanism are abolished. In the normal monkey optokinetic-ocular responses are reflected in sustained activity changes of central vestibular neurons within the vestibular nuclei. To account for the loss of optokinetic responses after labyrinthectomy, inactivation of central vestibular neurons consequent on the loss of primary vestibular activity is assumed to be of major importance. To test this hypothesis we recorded the neural activity within the vestibular nuclea…
A second-order sparse factorization method for Poisson's equation with mixed boundary conditions
1992
Abstract We propose an algorithm for solving Poisson's equation on general two-dimensional regions with an arbitrary distribution of Dirichlet and Neumann boundary conditions. The algebraic system, generated by the five-point star discretization of the Laplacian, is solved iteratively by repeated direct sparse inversion of an approximating system whose coefficient matrix — the preconditioner — is second-order both in the interior and on the boundary. The present algorithm for mixed boundary value problems generalizes a solver for pure Dirichlet problems (proposed earlier by one of the authors in this journal (1989)) which was found to converge very fast for problems with smooth solutions. T…
Conjugate Gradient Method for Brain Magnetic Resonance Images Segmentation
2018
Part 8: Pattern Recognition and Image Processing; International audience; Image segmentation is the process of partitioning the image into regions of interest in order to provide a meaningful representation of information. Nowadays, segmentation has become a necessity in many practical medical imaging methods as locating tumors and diseases. Hidden Markov Random Field model is one of several techniques used in image segmentation. It provides an elegant way to model the segmentation process. This modeling leads to the minimization of an objective function. Conjugate Gradient algorithm (CG) is one of the best known optimization techniques. This paper proposes the use of the nonlinear Conjugat…
Review of 8 years of experience with Infanrix hexa (DTPa-HBV-IPV/Hib hexavalent vaccine).
2009
Combination vaccines that include multiple antigens within one formulation are now widely accepted as an effective means of eliciting protection against several diseases at the same time. Owing to improvements in quality and convenient modes of administration, they have become part of routine pediatric practice. Hexavalent vaccines, including diphtheria, tetanus, pertussis, hepatitis B, polio and Haemophilus influenzae type b antigens represent the latest advance in the development of combination vaccines. Over 8 years since its first licensure, this review looks at the immunogenicity, efficacy and safety profile of the only hexavalent pediatric vaccine currently in use--Infanrix hexa (diph…
Hydrogen bond-mediated conjugates involving lanthanide diphthalocyanines and trifluoroacetic acid (Lnpc2@TFA): Structure, photoactivity, and stability
2020
The interaction between lanthanide diphthalocyanine complexes, LnPc2 (Ln = Nd, Sm, Eu, Gd, Yb, Lu
Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.
2006
Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provo…
SORTING CONJUGATES AND SUFFIXES OF WORDS IN A MULTISET
2014
In this paper we are interested in the study of the combinatorial aspects related to the extension of the Burrows-Wheeler transform to a multiset of words. Such study involves the notion of suffixes and conjugates of words and is based on two different order relations, denoted by <lex and ≺ω, that, even if strictly connected, are quite different from the computational point of view. In particular, we introduce a method that only uses the <lex sorting among suffixes of a multiset of words in order to sort their conjugates according to ≺ω-order. In this study an important role is played by Lyndon words. This strategy could be used in applications specially in the field of Bioinformatic…