Search results for " DAMAGE"

Suppression of extinction with TMS in humans: from healthy controls to patients.

2006

We review a series of studies exemplifying some applications of single-pulse and paired-transcranial magnetic stimulation (TMS) in the study of spatial attention and of its deficits. We will focus primarily on sensory extinction, the failure to consciously perceive a contralesional sensory stimulus only during bilateral stimulation of homologous surfaces. TMS studies in healthy controls show that it is possible either to interfere or modulate the excitability of the parietal cortex during sensory (i.e. tactile and visual) attentional tasks, thus reproducing a condition of virtual extinction. TMS studies in patients with unilateral (mainly right) brain damage show that the modulation of the …

alpha-Tocopherol, MDA-HNE and 8-OHdG levels in liver and heart mitochondria of adriamycin-treated rats fed with alcohol-free beer.

2008

Different studies indicate that oxidative stress and mitochondrial damage are key factors in different pathogenic process. The aim of this study was to investigate the possible protective role of alcohol-free beer on adriamycin-induced (ADR) heart and liver toxicity using biomarkers of oxidative stress. This effect was compared with the effect of alcohol beer intake and with a control group. Rats were randomly divided into six groups. The first group received no adriamycin, was fed with water and was regarded as the control group; the second group was injected with a ADR (two cycles of 5mg/kg); the third and fourth groups were fed with alcohol-free and beer for 21 days, respectively and the…

Influence d'une supplémentation en vitamines sur le rendement de la locomotion après une épreuve d'ultratrail

2006

International audience; Aim: The purpose of this study was to study changes in gross efficiency of locomotion after a prolonged trail running race (3000 m up and 300 m down). The second purpose was to investigate the effectiveness of supplementation in vitamin on gross efficiency variability.Materials and methods: Twenty-two well-trained endurance runners took part in this study. They had to perform four sub maximal tests before, 24, 48 and 72 hours after the race in order to estimate gross efficiency of locomotion and a maximal contraction test in the same period. They were divided in two groups either with supplementation (Isoxan Endurance ®) or without (placebo).Results: In both groups w…

Stochastic modeling and prediction of catalytic converters degradation

2009

This paper proposes a stochastic model for describing the degradation process of catalytic converters over time, where the degradation is indirectly measured through the emission of complex hydrocarbons (HC) in legislated driving cycles. The proposed model is the superposition of two processes, the former being a dependent increments process which describes the actual degradation process, and the latter a white noise process which models the experimental errors. In particular, the proposed model assumes that the degradation growth in a small usage interval depends on the degradation level at the beginning of the interval, rather than on the age of the converter. The model has been applied t…

Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

2016

AbstractInactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously shown that overexpression of the phosphatase Wip1 in p53-negative tumors sensitizes them to chemotherapeutic agents, while protecting normal tissues from the side effects of anti-cancer treatment. In this study, we decided to search for kinases that prevent Wip1-mediated sensitization of cancer cells, thereby interfering with efficacy of genotoxic anti-cancer drugs. To this end, we performed a flow cytometry-based screening in order to identify kinases that regulated the levels of γH2AX, which were used as readout. Another criter…

Traditional Architecture and seismic security. Earthquake in the Madonie inner mountain area of Sicily: damages and construction techniques

2017

Tra il 1818 e il 1819 una serie di centri siciliani concentrati nell'area montuosa delle Madonie, furono colpiti a più riprese da una sequenza di scosse sismiche che provocarono numerosi danni all’edificato storico, sia diffuso che di pregio. Il contributo intende indagare i danni e le conseguenti ricostruzioni, con particolare riferimento alle tipologie edilizie e alle tecniche costruttive adottate prima e dopo il sisma. L'azione di verifica e monitoraggio delle condizioni delle fabbriche e i conseguenti interventi di consolidamento e riparazione sono efficacemente documentati in testi a stampa e nei report coevi al sisma e –soprattutto- da una copiosa documentazione archivistica. Si ident…

Expression of the human XPB/ERCC-3 excision repair gene-homolog in the sponge Geodia cydonium after exposure to ultraviolet radiation.

1998

Abstract The marine demosponge Geodia cydonium encodes a gene, termed GCXPB , which displays 62% identity to the human XPB/ERCC-3 gene that specifically corrects the repair defect in xeroderma pigmentosum and in Cockayne's syndrome. The cDNA was isolated and characterized the deduced aa sequence, XPB_GEOCY, with the calculated size of 91,541 Da comprises the characteristic domains found in the related helicases. Phylogenetic tree analysis revealed that the sponge sequence is grouped to the metazoan related XPB/ERCC-3 polypeptides. Northern Blot analyses have been performed with sponge samples collected at different depths, thus exposed to different intensities of UV sunlight in the field. T…

Modelling of microcracked bodies using the concept of crack opening mode

2010

Reduced herbicide use does not increase crop yield loss if it is compensated by alternative preventive and curative measures

2018

Herbicide use must be reduced because of environmental and health issues. This raises the question of whether weeds and the resulting crop yield loss will increase. Previous studies analysing relationships between herbicide use intensity, weeds and yield loss suffer from methodological shortcomings in terms of weed flora and farm diversity as well as temporal scales. Here, we collected data on 272 arable cropping systems from one Spanish and six French regions, from farm surveys, the Biovigilance-Flore network, expert opinion, cropping system trials, crop advisors and scientists. Each system was simulated over 27 years and with 10 weather repetitions, using the virtual-field model FlorSys. …

Exploit biodiversity in viticultural systems to reduce pest damage and pesticide use, and increase ecosystems services provision: the BIOVINE Project

2018

Organic vineyards still rely on large external inputs to control harmful organisms (i.e., pests). The BIOVINE project aims to develop natural solutions based on plant diversity to control pests and reduce pesticide dependence. The capability of plants of increasing the ecosystem resistance to pests and invasive species is a well-known ecosystem service. However, monocultures (including vineyards) do not exploit the potential of plant diversity. BIOVINE aims to develop new viticultural systems based on increased plant diversity within (e.g., cover crops) and/or around (e.g., hedges, vegetation spots, edgings) vineyards by planting selected plant species for the control of arthropods, soil-bo…