Search results for " DELIVERY"

Clay-biosurfactant materials as functional drug delivery systems: Slowing down effect in the in vitro release of cinnamic acid

2017

Abstract The main objectives of the present paper were the preparation and characterization of new surfactant-modified clays and the evaluation of their potential applicability as drug delivery systems for the oral administration of the cinnamic acid (CA) drug. The organoclays (OC) were prepared by loading different amounts of the biocompatible nonionic polyoxyethylene sorbitan monolaurate surfactant (Tween20) onto K10 montmorillonite (Mt) clay and characterized through the construction of the adsorption isotherms by means of the spectrophotometric method. The performance of the prepared material was verified by gathering the adsorption isotherms of the cinnamic acid onto the Mt/Tween20 org…

Multicomponent solid dispersion as a formulation strategy to improve drug permeation: A case study on the anti-colorectal cancer irinotecan

2019

Abstract Multicomponent solid dispersions (MSD)s are frequently proposed as efficient drug delivery systems to improve drug solubility and bioavailability. In this study, the effects of specific excipients, such as mannitol, inulin, poly(methyl methacrylate-co-methacrylic)acid (PMMA) and cellulose acetate phthalate (CAP) have been tested to potentially improve irinotecan (IRN) permeation in the intestinal tract with the intention to protect the drug from the gastric environment. MSDs were formulated as microparticles by Spray-Drying technique. Raw materials and microparticles have been characterized by FTIR analysis to determine hydrogen bonding. SEM images were recorded to investigate morp…

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

2013

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that…

Fostering Collaborative Governance in Chronic Disease Management Programs: A Dynamic Performance Management Approach

2020

Chronic diseases are the leading cause of disability and mortality in the world and represent a global health emergency due to the increase in frequency and complexity that has been occurring in recent years. The outcomes related to chronic care needs depend on the joint effort of a multi-provider, multi-disciplinary, and multi-professional service network, which operates along a clinical pathway. However, all the different players involved in the provision of services may have different interests and goals derived from their organizational structure and their role in the overall health system. This context of fragmented governance makes performance management of care services problematic. …

Towards Next Generation System Architecture for Emergency Services

2011

European Union has decided that all emergencies can be reported to authorities by European citizens by calling 112 or sending a text message to 112. Distributing warnings and alerts of authorities to citizens currently happens through national TV and radio channels, but telecom networks are also used now in some countries for this purpose. During the last ten years there have been attempts to develop new system architectures for various emergency service provision phases. Some of them are already deployed in special cases, like in ambulance services. Multimedia emergency alert messages can be delivered to citizens over fixed and mobile telecom networks and commercial systems are already in …

Global trends in a fragile context : public–nonpublic collaboration, service delivery and social innovation

2020

PurposeThis study aims to enhance the understanding of the nature of collaboration between public and nonpublic actors in delivering social services and achieving social innovation in a fragile context, with an emphasis on the role of civil society organisations (CSOs). The paper focuses on Bosnia and Herzegovina, a Southeastern European country which has faced a turbulent post-conflict transition and experienced challenges in its social welfare policy and practice.Design/methodology/approachThis study uses institutional theory, particularly new institutionalism and institutional networking, as a lens through which to understand public and nonpublic collaboration and social innovation withi…

“AD HOC” MODIFIED CLAYS FOR BIOTECHNOLOGICAL APPLICATIONS

Nowadays, the scientific community has to face with cogent problems strictly linked to the improvement of quality of live. Among the different tasks to achieve the prefixed objective the focus has been put on the drug administration, i.e., attention has been paid to propose an appropriate solution to improve the performance of a drug delivery system and to eliminate both the side effect and drawbacks. With the aim to achieve the design, synthesis, and characterization of versatile systems, with peculiar characteristics, based on clays and clays modified with a biocompatible surfactant, able to adsorb and release organic substances of pharmaceutical interest the present PhD thesis has been u…

Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes

2020

Abstract Tobacco smoking is a leading cause of non-communicable disease globally and is a major risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by the World Health Organizations (WHO) indicate that in the last two decades global tobacco use has significantly dropped, which was largely driven by decreased numbers of female smokers. Despite such advances, the use of e-cigarettes and waterpipes (shisha, hookah, narghile) is an emerging trend, especially among younger generations. There is growing body of evidence that e-cigarettes are not a harm-free alternative to tobacco cigarettes and there is considerable debate as to whether e-cigarettes are saving …

Autonomic Brokerage Service for an End-to-End Cloud Networking Service Level Agreement

2014

8 pages; International audience; Today, cloud networking which is the ability to connect the user with his cloud services and to interconnect these services within an inter-cloud approach, is one of the recent research areas in the cloud computing research communities. The main drawback of cloud networking consists in the lack of Quality of Service (QoS) assurance and management in conformance with a corresponding Service Level Agreement (SLA). In this paper, we propose a framework for self-establishing an end-to-end service level agreement between a Cloud Service User (CSU) and multiple Cloud Service Providers (CSPs) in a cloud networking environment using brokerage service. We focus on Qo…

2013

The amyloid-β42 (Aβ42) peptide plays a crucial role in the pathogenesis of Alzheimer’s disease (AD), the most common neurodegenerative disorder affecting the elderly. Over the past years, several approaches and compounds developed for the treatment of AD have failed in clinical studies, likely in part due to their low penetration of the blood–brain barrier (BBB). Since nanotechnology-based strategies offer new possibilities for the delivery of drugs to the brain, this technique is studied intensively for the treatment of AD and other neurological disorders. The Aβ42 lowering drug flurbiprofen was embedded in polylactide (PLA) nanoparticles by emulsification-diffusion technique and their pot…