Search results for " DIABETES MELLITUS"
showing 10 items of 309 documents
Glycated Albumin for Glycemic Control in T2DM Population: A Multi-Dimensional Evaluation.
2021
Lucrezia Ferrario,1 Fabrizio Schettini,1 Angelo Avogaro,2 Chiara Bellia,3 Federico Bertuzzi,4 Graziella Bonetti,5 Antonio Ceriello,6 Marcello Ciaccio,3,7 Massimiliano Corsi Romanelli,8,9 Elena Dozio,9 Luca Falqui,10 Angela Girelli,11 Antonio Nicolucci,12 Gianluca Perseghin,13,14 Mario Plebani,15 Umberto Valentini,11 Martina Zaninotto,15 Silvana Castaldi,9,16 Emanuela Foglia1 1Centre for Health Economics, Social and Health Care Management, Università Carlo Cattaneo - LIUC, Castellanza, Italy; 2Department of Medicine, University-Hospital of Padova, Padova, Italy; 3Section of Clinical Biochemistry and Clinical Molecular Medicine, Department of Biopathology and Medical Biotechnologie…
Interactive Process Mining in Type 2 Diabetes Mellitus
2020
This chapter is a descriptive use case of the Interactive Process Mining paradigm in one of the most significant problems of healthcare in relation to the management of chronic conditions, Type 2 Diabetes Mellitus. The chapter firstly performs a comprehensive description of the disease, its origins, evolution and standard of care, to thereafter adapt the concepts of Interactive Process Mining to trigger big quantities of heterogeneous observational data into actionable information for patient’s evaluations. The use case is focused in the analysis of Glycated Hemoglobin, a major indicator of blood glucose levels and a key factor in the management of the disease. The chapter is a preliminary …
CARDIOMETABOLIC SYNDROME AND SARCOPENIC OBESITY IN OLDER PERSONS
2007
The aging of the world's population is a major contributor to the growing prevalence of the cardiometabolic syndrome (CMS) because older persons are more affected by the constellation of cardiovascular risk factors that constitute the syndrome. The prevalence of CMS has been related to the increasing prevalence of obesity, which is growing progressively even among older age groups. Indeed, obesity and aging are 2 overlapping mounting public health problems. It is currently accepted that CMS predicts cardiovascular mortality and/or the development of type 2 diabetes mellitus, and this is also true in studies including older persons. CMS is further complicated by modifications in body composi…
COMMENTARY TO THE LETTER TO THE EDITOR
2011
mrh.2011.0274 Auteur(s) : Mario Barbagallo mabar@unipa.it, Ligia J Dominguez Geriatric Unit, Dept. of Internal Medicine and Emergent Pathologies, University of Palermo, Italy Correspondence: M. Barbagallo Dear Editor, We thank Dr Kisters for his comments; we agree with the potentiality of magnesium supplementation in the management of hypertension. However, although our data show the effectiveness of magnesium supplementation to improve endothelial vascular function [1], we would be more [...]
Main Problems of Diabetes Mellitus Type 2 Patients in Keeping Diet
2015
A research has been carried out to assess the awareness of patients about the importance of diet, the availability of information and to make the diabetes patients with mellitus type 2 realize the urgency of dieting. The first part looks into theoretical sources and statistics about how widespread diabetes mellitus type 2 is and the importance of a healthy diet. The practical part of the research consists of the survey results. The method of quantitative research was applied. The conclusions and suggestions have been made based on the research results.
Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?
2022
AbstractIn diabetes mellitus (DM), there is increased formation and accumulation of advanced glycation end products (AGEs), which represent a heterogeneous class of molecules produced by non-enzymatic glycation of various molecules during long-term hyperglycaemia. Several studies have examined the role of AGEs in DM complications. Accumulating evidence suggests that AGEs affect bone metabolism. New knowledge indicates that they may play a role in bone disease among DM subjects. More data are now needed to clarify their role and to explore new AGEs-based therapeutic options for optimal bone health in DM.
Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases
2022
Diabetes mellitus is a comprehensive expression to identify a condition of chronic hyperglycemia whose causes derive from different metabolic disorders characterized by altered insulin secretion or faulty insulin effect on its targets or often both mechanisms. Diabetes and atherosclerosis are, from the point of view of cardio- and cerebrovascular risk, two complementary diseases. Beyond shared aspects such as inflammation and oxidative stress, there are multiple molecular mechanisms by which they feed off each other: chronic hyperglycemia and advanced glycosylation end-products (AGE) promote ‘accelerated atherosclerosis’ through the induction of endothelial damage and cellular dysfunction. …
Anti-inflammatory Therapies for Cardiovascular Disease: Signaling Pathways and Mechanisms
2019
Cardiovascular diseases (CVD) are the clinical manifestation of atherosclerosis, a chronic inflammatory disease promoted by several risk factors such as dyslipidemia, type 2 diabetes mellitus, hypertension, and smoking. Acute CVD events are the result of an unresolved inflammatory chronic state that promotes the rupture of unstable plaque lesions. Of note, the existing intensive therapies modify risk factors but do not prevent life-threatening recurrent ischemic events in high-risk patients, who have a residual inflammatory risk displayed by increased C-reactive protein (CRP) levels. Better understanding of the role of innate and adaptive immunity in plaque development and rupture has led t…
Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes
2015
Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality. Diabetic foot syndrome (DFS), as defined by the World Health Organization, is an "ulceration of the foot (distally from the ankle and including the ankle) associated with neuropathy and different grades of ischemia and infection". Pathogenic events able to cause diabetic foot ulcers are multifactorial. Among the commonest causes of this pathogenic pathway it's possible to consider peripheral neuropathy, foot deformity, abnormal foot pressures, abnormal joint mobility, trauma, peripheral artery disease. Several studies reported how …
Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
2017
BACKGROUND Degludec is an ultralong-Acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-To-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. METHODS We randomly assigned 7637 patients with type 2 diabetes to receive either insulin degludec (3818 patients) or insulin glargine U100 (3819 patients) once daily between dinner and bedtime in a double-blind, treat-To-Target, event-driven cardiovascular outco…