Search results for " DIP"
showing 10 items of 1273 documents
DNA ploidy and S-phase fraction, but not p53 or NM23-H1 expression, predict outcome in colorectal cancer patients. Result of a 5-year prospective stu…
2002
Purpose: The aim of this study was to determine TP53 and NM23-H1 immunoreactivity, DNA ploidy, and S-phase fraction (SPF) in a series of 160 patients undergoing resective surgery for primary operable colorectal cancer (CRC) and to establish whether these alterations have any clinical value in predicting CRC patients' prognosis. Methods: TP53 and NM23-H1 expressions were evaluated on paraffin-embedded tissue by immunohistochemistry and DNA-ploidy and SPF on frozen tissue by flow-cytometric analysis. Results: The median follow-up time in our study group was 71 months (range 34-115 months). P53 protein expression was associated with distal tumors (P < 0.05) and DNA aneuploid tumors (P < …
Nm-23-H1 expression does not predict clinical survival in colorectal cancer patients
2003
The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in 160 patients undergoing surgery for colorectal cancer (CRC), the expression of the Nm23-H1 protein and to evaluate its possible associations with traditional clinicopathologic variables, with DNA-ploidy and proliferative activity (S-phase fraction, SPF), and with disease-free and overall survival of patients. Nm23-H1 expressions were evaluated on paraffin-embedded tissue by im…
Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study.
2012
ABSTRACT Background Data are limited regarding bone metastases from colorectal cancer (CRC). The objective of this study was to survey the natural history of bone metastasis in CRC. Patients and methods This retrospective, multicenter, observational study of 264 patients with CRC involving bone examined cancer treatments, bone metastases characteristics, skeletal-related event (SRE) type and frequency, zoledronic acid therapy, and disease outcomes. Results Most patients with bone metastases had pathologic T3/4 disease at CRC diagnosis. The spine was the most common site involved (65%), followed by hip/pelvis (34%), long bones (26%), and other sites (17%). Median time from CRC diagnosis to b…
Reply: 18F-FDG PET for Routine Posttreatment Surveillance in Oral and Oropharyngeal Squamous Cell Carcinoma
2010
1164 Objectives 68Ga-BPAMD (BPAMD = (4-{[bis-(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxy methyl)-1,4,7,10-tetraazacyclododec-1-yl)acetic acid) was used in a first human in vivo study for diagnosis of osteoblastic bone metastases. The DOTA-based bisphosphonate ligand BPAMD may also be suitable for complexation with therapeutic radionuclides such as 177Lu. The same ligand thus may be used for diagnosis, dosimetry calculation, therapy and therapy control via PET/CT. Methods 177Lu was provided in 0.04 M HCl via the 176Yb(n,γ)177Yb→177Lu production process. Labelling was studied using different amounts of ligand in acetate buffer at pH 4-5 and different temperatures. For quality control…
Radiative lifetimes of Am I atomic levels.
1988
The lifetimes of several atomic levels of Am I that are connected by electric dipole transitions to the ground state have been measured. The Am atoms were excited by light pulses from a cw single-mode dye laser with the aid of an optoacoustic modulator. The decay curve of the delayed emitted photons was measured by counting single photons in the beam-off periods. The lifetimes of 14 levels in the wavelength region between 6405 and 4265 A were measured using Am-metal vapor. The metallic Am was obtained by reducing AmO/sub 2/ with La at 1500 /sup 0/C in a high-vacuum system and collecting Am on a catcher foil. The Am vapor was then produced by controlled reevaporation from the foil at a tempe…
Absorption Properties of Metal–Semiconductor Hybrid Nanoparticles
2011
The optical response of hybrid metal-semiconductor nanoparticles exhibits different behaviors due to the proximity between the disparate materials. For some hybrid systems, such as CdS-Au matchstick-shaped hybrids, the particles essentially retain the optical properties of their original components, with minor changes. Other systems, such as CdSe-Au dumbbell-shaped nanoparticles, exhibit significant change in the optical properties due to strong coupling between the two materials. Here, we study the absorption of these hybrids by comparing experimental results with simulations using the discrete dipole approximation method (DDA) employing dielectric functions of the bare components as input…
Secular spin-down of the AMP XTE J1751-305
2011
Context. Of the 13 known accreting millisecond pulsars, only a few showed more than one outburst during the RXTE era. XTE J1751-305 showed, after the main outburst in 2002, other three dim outbursts. We report on the timing analysis of the latest one, occurred on October 8, 2009 and serendipitously observed from its very beginning by RXTE. Aims. The detection of the pulsation during more than one outburst permits to obtain a better constraint of the orbital parameters and their evolution as well as to track the secular spin frequency evolution of the source. Methods. Using the RXTE data of the last outburst of the AMP XTE J1751-305, we performed a timing analysis to improve the orbital para…
Upper body strength endurance evaluation: A comparison between the handgrip strength and three body weight tests
2021
BACKGROUND: The hand-grip strength test has been widely adopted to evaluate upper limb strength. Other field based tests as push-ups and pull-ups are commonly used for the same purpose. It is however unclear if these may be used interchangeably for upper body strength evaluation. OBJECTIVE: The purpose of this investigation was to evaluate strength endurance of the upper body and understand which test could be the most appropriate for upper body evaluation. METHODS: Thirty-eight healthy young male participants were tested with three tests comprised of: 1) push-ups (PS), 2) pull-ups (PL) and 3) parallel dips (PD) performed to exhaustion. Grip strength (GS), total number of repetitions, time-…
Zvaigžņotā Debess: 2013, Vasara (220)
2013
Saturs: Pēdējā "Apollo" ekspedīcija uz Mēnesi ; Vissavienības Astronomijas un ģeodēzijas biedrības Latvijas nodaļa ; M.Gills. ESON – astronomijas popularizēšanas tīkls ; S.Kropa. Dvēsele Atakamas tuksnesī ; M.G. Īsumā: ESO Astro Camp Eiropas vidusskolēniem 2013.gada decembrī ; A.Alksnis. Atklāta vēl viena no Saulei vistuvākajām kaimiņzvaigznēm ; A.Alksnis. Tuvēja zvaigzne, kas ir izveidojusies jau drīz pēc Lielā Sprādziena ; A.Alksnis. Čeļabinskas superbolīds – simtgades notikums ; A.Alksnis. Nevis pārsteidzoša nova, bet gan kvazāra uzliesmojums ; I.Eglītis. Orius – Baldones observatorijā atklātais centaurs ; R.Misa. Denisa Tito Marsa iedvesmas fonds ; A.A. Īsumā: Ap zvaigzni Gleznotāja Bet…
Design of experiment approach for the optimization of polybrominated diphenyl ethers determination in fine airborne particulate matter by microwave-a…
2015
Abstract A sensitive and selective procedure for the determination of 12 polybrominated diphenyl ethers (BDE-28, BDE-49, BDE-47, BDE-66, BDE-100, BDE-119, BDE-99, BDE-155, BDE-154, BDE-153, BDE-139 and BDE-183) in airbone particulate matter (PM2.5) at trace level has been developed. The proposed method includes extraction PM2.5-bound PBDEs by microwave-assisted extraction (MAE) followed by gel permeation chromatography (GPC) clean-up and determination by GC-MS/MS using a programmed temperature vaporizer (PTV) in large volume injection (LVI) mode to introduce the sample to the chromatographic system. A design of experiment (DoE) approach was used for the optimization of large volume injectio…