Search results for " DOC"
showing 10 items of 1281 documents
La morería de Valencia en el reinado de Juan II
1980
„Sutry Jezusa” – pierwsze syntezy chrystologiczne Dalekiego Wschodu
2019
Artykuł prezentuje badania dotyczące zabytkowych „dokumentów nestoriańskich” zwanych „Sutrami Jezusa”, które powstały podczas pierwszej misji Kościoła Wschodu do Chin w VII w. pod przewodnictwem Alopena. Teksty te są syntezą chrystologii oraz elementów teologii chrześcijańskiej istotną z punktu widzenia misji w Chinach. Opisują dogmaty chrześcijańskie za pomocą taoistycznej i buddyjskiej terminologii, filozofii, an-tropologii, kosmologii i symboliki. Są świadectwem rozwoju Kościoła w Chinach w ciągu trzech wieków za panowania dynastii Tang. „Sutry Jezusa” są odpowiedzią na pytanie: Co i w jaki sposób opowiedział Kościół o Jezusie Chrystusie po raz pierwszy Dalekiemu Wschodowi? Większość oma…
Studi greci e latini nell?antica Università di Altamura (1748-1821)
2019
The article tries to highlight, despite the scarse of available documentation, the Greek and Latin studies (language and texts) in the ancient Apulian University in Altamura (1748-1821). Furthermore, on the basis of unpublished archival materials (school registers and student workbooks) it is possible to shed light on the ancient authors explained at school, the teaching methods, and the study practices.
Identification of a new series of amides as non-covalent proteasome inhibitors
2014
Proteasome inhibition has emerged as an important therapeutic strategy for the treatment of multiple myeloma (MM) and some forms of lymphoma, with potential application in other types of cancers. 20S proteasome consists of three different catalytic activities known as chymotrypsin-like (ChT-L), trypsin-like (T-L), and, post-glutamyl peptide hydrolyzing (PGPH) or caspase-like (C-L), which are located respectively on the β5, β2, and β1 subunits of each heptameric β rings. Currently a wide number of covalent proteasome inhibitors are reported in literature; however, the less widely investigated non-covalent inhibitors might be a promising alternative to employ in therapy, because of the lack o…
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening
2013
The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.
Language Documentation and Descriptive Linguistics
2021
A Novel Series of Acylhydrazones as Potential Anti-Candida Agents: Design, Synthesis, Biological Evaluation and In Silico Studies
2019
In the context of an increased incidence of invasive fungal diseases, there is an imperative need of new antifungal drugs with improved activity and safety profiles. A novel series of acylhydrazones bearing a 1,4-phenylene-bisthiazole scaffold was designed based on an analysis of structures known to possess anti-Candida activity obtained from a literature review. Nine final compounds were synthesized and evaluated in vitro for their inhibitory activity against various strains of Candida spp. The anti-Candida activity assay revealed that some of the new compounds are as active as fluconazole against most of the tested strains. A molecular docking study was conducted in order to evaluate the …
Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.
2020
Abstract Background Depression and stress-related disorders are leading causes of death worldwide. Standard treatments elevating serotonin or noradrenaline levels are not sufficiently effective and cause adverse side effects. A connection between dopamine pathways and stress-related disorders has been suggested. Compounds derived from herbal medicine could be a promising alternative. We examined the neuroprotective effects of ursolic acid (UA) by focusing on dopamine signalling. Methods Trolox equivalent capacity assay was used to determine the antioxidant activities of UA in vitro. C. elegans N2 wildtype and dopamine receptor-knockout mutants (dop-1-deficient RB665 and dop-3-deficient LX70…
The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.
2021
Abstract Introduction Depression is one of the leading causes of death worldwide. Lower antioxidant concentrations and increased oxidative stress levels contribute to the development of depression. Effective and tolerable medications are urgently needed. Nrf2 and PRDX2 are promising targets in the treatment of oxidative stress and, therefore, promising for the development of novel antidepressants. Ursolic acid (UA), a natural triterpenoid found in various plants is known to exert neuroprotective and antioxidant effects. Skn-1 (which corresponds to human Nrf2) and prdx2 deficient mutants of the nematode Caenorhabditis elegans are suitable models to study the effect of UA on these targets. Ad…
L'Autorità garante della concorrenza e del mercato ei prgrammi di clemenza
2010
A distanza di tre anni dall'introduzione dei programmi di clemenza nella legge antitrust italiana, si impone una riflessione sui problemi aperti dalla loro adozione e applicazione. Il contributo li esamina, comparando il sistema italiano con quello comunitario e con gli altri sistemi vigenti nell'ambito dell'ECN. Evidenzia, quindi, alcuni aspetti critici della disciplina italiana, relativi all'accesso dei terzi alle dichiarazioni confessorie e alla documentazione allegata.