Search results for " DOC"
showing 10 items of 1281 documents
Del paradigma de la enseñanza al paradigma del aprendizaje: un programa de capacitación docente, su influencia en los profesores y en el aprendizaje …
2016
INTRODUCCIÓN: Las últimas décadas de investigación en Educación superior han generado fundamentación científica que soporta el cambio desde el paradigma de la enseñanza al paradigma del aprendizaje. Este cambio exige pasar de una concepción del conocimiento atomística a una holística; de un enfoque competitivo e individualista del aprendizaje a la generación de ambientes de aprendizaje cooperativos, colaborativos y de apoyo; del papel de los profesores como conferencistas a un papel de guías en el proceso de aprendizaje. Sin embargo, el cambio no ha sido automático y dentro de un amplio espectro entre los dos paradigmas se pueden encontrar también posiciones intermedias que definen los los …
La utilització de WebQuest i de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats
2010
Aquest treball té com objectiu estudiar la importància d'implantar metodologies docents centrades en les noves tecnologies de la informació i comunicació (TIC), amb la finalitat de potenciar la participació de l'estudiant i de millorar els seus resultats d'aprenentatge. Concretament,aprofundirem en el disseny d'una WebQuest i en l'ús de Sistemes de Resposta Interactiva en l'assignatura Investigació de Mercats. Els resultats obtinguts serviran de base per a dissenyar les guies i metodologies docents de les assignatures de l'àrea de Comercialització i Investigació de Mercats en els nous estudis de grau.
The Impact of COVID-19 on Sport in Twitter: A Quantitative and Qualitative Content Analysis
2021
The spread of the SARS-CoV-2 virus has transformed many aspects of people’s daily life, including sports. Social networks have been flooded on these issues. The present study aims to analyze the tweets produced relating to sports and COVID-19. From the end of January to the beginning of May 2020, over 4,000,000 tweets on this subject were downloaded through the Twitter search API. Once the duplicates, replicas, and retweets were removed, 119,253 original tweets were analyzed. A quantitative–qualitative content analysis was used to study the selected tweets. Posts dynamics regarding sport and exercise evolved according to the COVID-19 pandemic and subsequent lockdown, shifting from consideri…
Using Internet videos to learn about controversies: Evaluation and integration of multiple and multimodal documents by primary school students
2020
Abstract In many Internet videos authors appear in front of the camera to present their particular view on a topic. Given the high consumption rate of Internet videos by teenagers, we explored the pros and cons of using these videos to learn about complex topics, compared to learning from textual web pages. Specifically, we studied how 207 primary school students (grades 4–6) evaluated and integrated multiple and multimodal web pages (text or video) while learning about the pros and cons of bottled water. Results showed no major role of modality in students' source memory, as measured by citations in their responses to an integration question and their memory for sources. Nevertheless, moda…
In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection
2020
COVID-19 is a pandemic health emergency faced by the entire world. The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). This work proposes a repurposing process using a database containing approximately 8000 known drugs in synergy structure- and ligand-based studies by means of the molecular docking and descriptor-based protocol. The proposed in silico findings identified new potential SARS CoV-2 main protease (MPRO) inhibitors that fit in the catalytic binding site of SARS CoV-2 MPRO. Several sel…
Synthesis, photophysical properties and structures of organotin-Schiff bases utilizing aromatic amino acid from the chiral pool and evaluation of the…
2017
Abstract Five new organotin(IV) complexes of compositions [Me 2 SnL 1 ] ( 1 ), [Me 2 SnL 2 ] n ( 2 ), [Me 2 SnL 3 ] ( 3 ), [Ph 3 SnL 1 H] n ( 4 ) and [Ph 3 SnL 3 H] ( 5 ) (where L 1 = (2 S )-2-(( E )-(( Z )-4-hydroxypent-3-en-2-ylidene)amino)-3-(1 H -indol-3-yl)propanoate, L 2 = (2 S )-( E )-2-((2-hydroxybenzylidene)amino)-3-(1 H -indol-3-yl)propanoate and L 3 = (2 S )-( E )-2-((1-(2-hydroxyphenyl)ethylidene)amino)-3-(1 H -indol-3-yl)propanoate were synthesized and spectroscopically characterized. The crystal structures of 1 – 4 were determined. For the dimethyltin derivative 2 , a polymeric chain structure was observed as a result of a long Sn∙∙∙O contact involving the exocyclic carbony…
Molecular Docking approach on the Topoisomerase I inhibitors series included in the NCI anti-cancer agents mechanism database
2006
Topoisomerase I (Top1) is an essential enzyme participating to all those processes associated with separation of DNA strands. It manages superhelical tensions through the transient breakage of one strand of duplex DNA, followed by the unwinding of supercoiled DNA. Camptothecins, a class of alkaloids extracted from the wood of a Chinese tree, were found to be potent inhibitors of Topoisomerase I. The National Cancer Institute (NCI) Anti-cancer Agents Mechanism Database contains several camptothecins derivatives, classified as selective Top1 inhibitors. In this work we performed molecular docking studies on 24 camptothecin-like inhibitors present in this database (using Autodock 3.0.5). In or…
Targeting the Class A Carbapenemase GES-5 via Virtual Screening
2020
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Structural determinants of resveratrol for cell proliferation inhibition potency: experimental and docking studies of new analogs.
2010
International audience; Resveratrol is the subject of intense research because of the abundance of this compound in the human diet and as one of the most valuable natural chemopreventive agents. Further advances require new resveratrol analogs be used to identify the structural determinants of resveratrol for the inhibition potency of cell proliferation by comparing experimental and docking studies. Therefore, we synthesized new trans/(E)- and cis/(Z)-resveratrol - analogs not reported to date - by modifying the hydroxylation pattern of resveratrol and a double bond geometry. We included them in a larger panel of 14 molecules, including (Z)-3,5,4'-trimethoxystilbene, the most powerful molec…
Pyrazolobenzotriazinones Derivatives as COX Inhibitors: Synthesis Biological Activity and Molecular Modeling Studies
2010
Pyrazolylbenzotriazinones are endowed with structural analogy with the COX-2 selective inhibitor celecoxib. Considering that our research group has long been interested in the 3-pyrazolyl-substituted benzotriazinones as anti-inflammatory agents, six new pyrazolylbenzotriazinone derivatives 16a-c and 18a-c have been prepared by reacting the opportune ethyl 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate or 5-(2-aminobenzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxyic acid with sodium nitrite in glacial acetic acid. The biological studies revealed a good pharmacological profile for some pyrazolylbenzotriazinones and, in the case of the ethyl 5-(4-oxo-1,2,3-benzotriazin-3(4H)-y…