Search results for " DOC"
showing 10 items of 1281 documents
Personiskās elektroniskās informācijas organizēšanas paradumi
2018
Bakalaura darba temats ir personiskās elektroniskās informācijas organizēšanas paradumi. Elektroniski glabājamo dokumentu skaits katru gadu pieaug, līdz ar to, tas meklēšana un kārtošana var aizņemt laiku, lai atvieglot šo procesu rodas nepieciešamība pēc elektronisko dokumentu organizēšanas izpētēs. Darba mērķis ir noskaidrot, kādi ir cilvēku personiskās elektroniskās informācijas organizēšanas paradumi. Bakalaura darba teorētisko bāzi veido sociāli kognitīvā teorija. Pētījumā tiek izmantotas kvalitatīvas pētniecības metodes – intervija un verbālais protokols. Pētījuma empīriskā bāze sastāv no apkopotiem interviju un verbālo protokolu rezultātiem. No respondentiem tika noskaidrots, kā viņi…
Vicisitudes demográficas en Vila-Real durante el siglo XV
2009
Utilizando las fuentes documentales conservadas en el Archivo Municipal de Vilareal nos aproximamos a la dinámica demográfica de dicha localidad, observando los incesantes intentos municipales por mantener un óptimo nivel poblacional pese a las hambrunas, las carestías, las mortalidades, la guerra, etc. También analizamos el incesante, y a la vez contradictorio, movimiento migratorio. Finalmente dedicamos unas líneas a la formación de la morería en 1489. (A)
Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach
2022
Vitamin D’s role in combating the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the virus causing COVID-19, has been established in unveiling viable inhibitors of COVID-19. The current study investigated the role of pre and pro-vitamin D bioactives from edible mushrooms against Mpro and PLpro proteases of SARS-CoV-2 by computational experiments. The bioactives of mushrooms, specifically ergosterol (provitamin D2), 7-dehydrocholesterol (provitamin-D3), 22,23-dihydroergocalciferol (provitamin-D4), cholecalciferol (vitamin-D3), and ergocalciferol (vitamin D2) were screened against Mpro and PLpro. Molecular docking analyses of the generated bioactive protease complexes unr…
Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular…
2019
In the context of there being a limited number of clinically approved drugs for the treatment of Candida sp.-based infections, along with the rapid development of resistance to the existing antifungals, two novel series of 4-phenyl-1,3-thiazole and 2-hydrazinyl-4-phenyl-1,3-thiazole derivatives were synthesized and tested in vitro for their anti-Candida potential. Two compounds (7a and 7e) showed promising inhibitory activity against the pathogenic C. albicans strain, exhibiting substantially lower MIC values (7.81 &mu
Evaluation of the IKKβ Binding of Indicaxanthin by Induced-Fit Docking, Binding Pose Metadynamics, and Molecular Dynamics
2021
Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of human melanoma cells through the inhibition of NF-κB as the predominant pathway. Specifically, Indicaxanthin inhibited IκBα degradation in A375 cells. In resting cells, NF-κB is arrested in the cytoplasm by binding to its inhibitor protein IκBα. Upon stimulation, IκBα is phosphorylated by the IKK complex, and degraded by the proteasome, liberating free NF-κB into the nucleus to initiate target gene transcription. Inhibition of the IKK complex leads to the arrest of the NF-κB pathway.Methods: To acquire deta…
Risk analysis in bioequivalence and biowaiver decisions
2013
This article evaluates the current biowaiver guidance documents published by the FDA, EU and WHO from a risk based perspective. The authors introduce the use of a Failure Mode and Effect Analysis (FMEA) risk calculation tool to show that current regulatory documents implicitly limit the risk for bioinequivalence after granting a biowaiver by reduction of the incidence, improving the detection and limiting the severity of any unforeseen bioinequivalent product. In addition, the authors use the risk calculation to expose yet unexplored options for future extension of comparative in vitro tools for biowaivers.
Fragment- and negative image-based screening of phosphodiesterase 10A inhibitors.
2019
A novel virtual screening methodology called fragment- and negative image-based (F-NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A-specific small-molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F-NiB combines features from both fragment-based drug discovery and negative image-based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein-bound ligand(s) are seamlessly combined with the negative image of the target's ligand-binding cavity. This cavity- and fragment-based hybrid model, namely its shape and electr…
A MULTI-LEVEL FUNCTIONAL STUDY OF A SNAP25 AT-RISK VARIANT FOR BIPOLAR DISORDER AND SCHIZOPHRENIA
2019
Background The synaptosomal associated protein SNAP25 is crucial for synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions. We recently identified a promoter variant in SNAP25, rs6039769, associated with bipolar disorder and gene expression in prefrontal cortex. Methods Here, we performed a genetic association study using this variation on two independent cohorts of 288 and 173 subjects with schizophrenia and 315 unaffected control individuals. We replicated our results using data from the schizophrenia group of the Psychiatric Genomics Consortium (PGC). Functional consequences combined both in vitro and post-mortem gene expression analysis on 30 p…
Precision measurement of scaled momentum, charge multiplicity, and thrust in νμN and interactions
1999
By focusing on the notion of electronic document, we differentiate two evolutions which are useful to distinct titles: on the one hand are the documents, which have value of reference. Its administrator will take care to preserve its integrity and its context of production which is strongly significant. On the other hand are resources, evolutionary elements by nature, which the user must be able to appropriate and who must thus be placed at the disposal so that the production is erased, to focus on a logic of exploitation and service.