Search results for " DOC"
showing 10 items of 1281 documents
CCDC 983272: Experimental Crystal Structure Determination
2015
Related Article: Javier Pitarch-Jarque, Raquel Belda, Francesc Lloret, Jesús Ferrando-Soria, Pilar Navarro, Alberto Lopera, Enrique García-España|2015|Dalton Trans.|44|3378|doi:10.1039/C4DT03650F
CCDC 958832: Experimental Crystal Structure Determination
2014
Related Article: Pau Díaz-Gallifa, Oscar Fabelo, Laura Cañadillas-Delgado, Jorge Pasán, Ana Labrador, Francesc Lloret, Miguel Julve, and Catalina Ruiz-Pérez|2013|Cryst.Growth Des.|13|4735|doi:10.1021/cg4008679
CCDC 1049501: Experimental Crystal Structure Determination
2015
Related Article: Alina S. Dinca, Sergiu Shova, Adrian E. Ion, Catalin Maxim, Francesc Lloret, Miguel Julve, Marius Andruh|2015|Dalton Trans.|44|7148|doi:10.1039/C5DT00778J
CCDC 1823994: Experimental Crystal Structure Determination
2018
Related Article: Marta Mon, Rosaria Bruno, Jesús Ferrando-Soria, Lucia Bartella, Leonardo Di Donna, Marianna Talia, Rosamaria Lappano, Marcello Maggiolini, Donatella Armentano, Emilio Pardo|2018|Materials Horizons|5|683|doi:10.1039/C8MH00302E
CCDC 1938637: Experimental Crystal Structure Determination
2019
Related Article: Lucas H. G. Kalinke, Danielle Cangussu, Marta Mon, Rosaria Bruno, Estefania Tiburcio, Francesc Lloret, Donatella Armentano, Emilio Pardo, Jesus Ferrando-Soria|2019|Inorg.Chem.|58|14498|doi:10.1021/acs.inorgchem.9b02086
CCDC 1938635: Experimental Crystal Structure Determination
2019
Related Article: Lucas H. G. Kalinke, Danielle Cangussu, Marta Mon, Rosaria Bruno, Estefania Tiburcio, Francesc Lloret, Donatella Armentano, Emilio Pardo, Jesus Ferrando-Soria|2019|Inorg.Chem.|58|14498|doi:10.1021/acs.inorgchem.9b02086
Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone.
2013
T-cell protein tyrosine phosphatase (TCPTP) is a ubiquitously expressed non-receptor protein tyrosine phosphatase. It is involved in the negative regulation of many cellular signaling pathways. Thus, activation of TCPTP could have important therapeutic applications in diseases such as cancer and inflammation. We have previously shown that the α-cytoplasmic tail of integrin α1β1 directly binds and activates TCPTP. In addition, we have identified in a large-scale high-throughput screen six small molecules that activate TCPTP. These small molecule activators include mitoxantrone and spermidine. In this study, we have investigated the molecular mechanism behind agonist-induced TCPTP activation.…
Study of the themes and contents of the doctoral theses carried out in Spain on Sports Biomechanics
2022
El objeto del estudio es conocer y valorar la evolución de las temáticas y contenidos de las tesis doctorales que se han leído en España sobre Biomecánica Deportiva durante el periodo comprendido entre los años 1980 y 2019. La muestra está compuesta de 233 tesis después de un proceso de selección con el uso de criterios de inclusión/exclusión y términos de búsqueda específicos. Los resultados demuestran que existe un crecimiento progresivo en la producción de tesis doctorales a lo largo del tiempo con incrementos progresivos, especialmente en el tercer y cuarto periodo. Los campos temáticos con mayor número de tesis leídas son los de Biomecánica de Apoyo y de Biomecánica Aplicada. El campo …
Low density lipoproteins and human serum albumin as the carriers of squalenoylated drugs: insights from molecular simulations
2018
We have studied the interaction of three clinically promising squalenoylated drugs (gemcitabine-squalene, adenine-squalene, and doxorubicin-squalene) with low-density lipoproteins (LDL) by means of atomistic molecular dynamics simulations. It is shown that all studied squalenoylated drugs accumulate inside the LDL particles. This effect is promoted by the squalene moiety, which acts as an anchor and drives the hydrophilic drugs into the hydrophobic core of the LDL lipid droplet. Our data suggest that LDL particles could be a universal carriers of squalenoylated drugs in the bloodstream. Interaction of gemcitabine-squalene with human serum albumin (HSA) was also studied by ensemble of dockin…
Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action
2019
Abstract New compounds able to counteract staphylococcal biofilm formation are needed. In this study we investigate the mechanism of action of pyrrolomycins, whose potential as antimicrobial agents has been demonstrated. We performed a new efficient and easy method to use microwave organic synthesis suitable for obtaining pyrrolomycins in good yields and in suitable amount for their in vitro in-depth investigation. We evaluate the inhibitory activity towards Sortase A (SrtA), a transpeptidase responsible for covalent anchoring in Gram-positive peptidoglycan of many surface proteins involved in adhesion and in biofilm formation. All compounds show a good inhibitory activity toward SrtA, havi…