Search results for " DOC"
showing 10 items of 1281 documents
Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol
2019
Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.
A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors.
2012
In this study we report the design, synthesis, and biological evaluation of constrained aminopyridinylimidazoles as p38α MAP kinase inhibitors. The frozen analogue approach focused on the pyridinyl unit, using purine bioisosteres as constrained structure analogues. The identification of the most potent bioisostere was followed by a further derivatization to address hydrophobic region II. In combination with C-2 modifications of the imidazole core, we were able to design highly active inhibitors on the p38α MAP kinase. The inhibitor design presented herein represents a promising and highly efficient advancement of recent stages of development in this class of p38 MAP kinase inhibitors. In co…
Longitudinal Study of Cytokine Expression, Lipid Profile and Neuronal Growth Factors in Human Breast Milk from Term and Preterm Deliveries
2015
Breast milk (BM) is considered as a reference for infant nutrition. The role of bioactive components, such as cytokines, hormones, growth factors (GFs) and fatty acids (FAs) is poorly known, but they might be implicated in immune response development. The aim of this study was to identify the lipid profile and the spectrum of cytokines and neuronal GF in BM samples and analyse the influence of gestational age and lactation time on these components. This study used a longitudinal prospective method for the characterization of cytokines, FAs and GFs global profiles in 120 BM samples from 40 healthy mothers (20 preterm and 20 term) collected as colostrum, transitional and mature milk. The cyto…
Experimental BIM applications in Archaeology: a work-flow
2014
In the last few decades various conceptual models, methods and techniques have been studied to allow 3D digital access to Cultural Heritage (CH). Among these is BIM (Building Information Modeling): originally built up for construction projects, it has been already experimented in the CH domain, but not enough in the archaeological field. This paper illustrates a framework to create 3D archaeological models integrated with databases using BIM. The models implemented are queryable by the connection with a Relational Database Management System and sharable on the web. Parametric solid and semantic models are integrated with 3D standardized database models that are finally manageable in the pub…
A reflective characterisation of occasional user
2017
This work revisits established user classifications and aims to characterise a historically unspecified user category, the Occasional User (OU). Three user categories, novice, intermediate and expert, have dominated the work of user interface (UI) designers, researchers and educators for decades. These categories were created to conceptualise user's needs, strategies and goals around the 80s. Since then, UI paradigm shifts, such as direct manipulation and touch, along with other advances in technology, gave new access to people with little computer knowledge. This fact produced a diversification of the existing user categories not observed in the literature review of traditional classificat…
La investigación en Ciencias Laborales como una nueva dimensión del alumnado universitario. Una experiencia innovadora
2016
Profesorado del Grado de Relaciones Laborales y Recursos Humanos de la Universitat de València, se planteó en el curso 2013-2014, y dado que la titulación había pasado de Diplomatura a Grado, la necesidad de fomentar entre el alumnado la orientación investigadora, opción hasta dicho momento difícil de desarrollar. Por eso, a través del desarrollo del proyecto de innovación en dicho curso «Medios para la difusión de resultados de investigaciones en Ciencias Laborales», se creó una web (http://inveslab.blogs.uv.es/) en la que se recogieron los resultados obtenidos del mismo, un repositorio con los medios existentes para la difusión de los resultados de investigaciones en Ciencias Laborales. T…
Compartir datos de investigación en cardiología
2013
El artículo expone las ventajas que aporta el compartir datos en la investigación en el área de cardiología
Revista electrónica de investigación y evaluación educativa
2010
The aim of this work is the development of a model that can be used as a framework for evaluators and PhD tribunal members, either during the previous administrative processing phase or at the actual exposition and viva on doctoral dissertations. To this end, once reviewed the existing literature and normative, a new proposal is laid out on the main aspects and criteria to be analysed and assessed from any given scientific work, thus introducing a tool that facilitates and specifies this work. Our model is intended to be an open proposal on which we would welcome any contribution and suggestion. El objetivo del presente trabajo es la elaboración de un modelo que pueda ser utilizado como mar…
Factores relevantes de la Calidad de Vida Docente de los profesores de la UASD: Un estudio exploratorio
2015
El objetivo fundamental de esta investigación consistió en identificar los factores relevantes de la calidad de vida docente de los profesores de la Universidad Autónoma de Santo Domingo considerando la personalidad, satisfacción, burnout y valores y con las variables sociodemográficas edad, sexo, los años trabajando en la universidad, la cantidad de grupos a los que da clases, las horas dedicas a la institución, las horas dedicadas fuera a otras actividades laborales y total de horas trabajadas. Se plantea un modelo estadístico predictivo complejo de la calidad de vida docente a partir de estas variables. Se accede a la muestra a través de un estudio exploratorio, transversal de un solo mo…
La descentralización tributaria en la Segunda República - Cataluña
1977
Investigación del desarrollo del Título IV- de la hacienda del estatuto de Nuria hasta su aprobación del 15 de septiembre de 1932. Estudio de la implantación de los traspasos de servicios su valoración y la correspondiente descentralización tributaria aprobado el Estatuto de Cataluña hasta el 18 de julio de 1936 a través de la Comisión Mixta Comisión Revisora Nueva Comisión Mixta y reanudación de la 1a Comisión Mixta demostrando la incidencia de los efectos políticos que acontecen en España sobre dichas comisiones y los efectos políticos que se producen como consecuencia de la actuación de dichas comisiones mixtas. Se aportan documentos inéditos obtenidos en archivos oficiales que iluminan …