Search results for " DOM"
showing 10 items of 2750 documents
Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours
2008
Aims: To correlate the immunohistochemical detection of WWOX with histological measures and disease progression within the whole spectrum of urothelial bladder neoplasms. Methods and results: One hundred and one patients with primary bladder tumours were retrospectively analysed. Immunohistochemically, a polyclonal antibody was utilized and the level of WWOX protein expression was analysed by using a combined score system based on intensity of the reaction and percentage of immunoreactive tumour cells. WWOX protein expression was consistently expressed in non-neoplastic urothelium, whereas a progressive loss of immunoreactivity was observed as tumour grade and stage increased (P < 0.05). …
WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation
2014
International audience; BACKGROUND:Homozygous mutations in WWOX were reported in eight individuals of two families with autosomal recessive spinocerebellar ataxia type 12 and in two siblings with infantile epileptic encephalopathy (IEE), including one who deceased prior to DNA sampling.METHODS:By combining array comparative genomic hybridisation, targeted Sanger sequencing and next generation sequencing, we identified five further patients from four families with IEE due to biallelic alterations of WWOX.RESULTS:We identified eight deleterious WWOX alleles consisting in four deletions, a four base-pair frameshifting deletion, one missense and two nonsense mutations. Genotype-phenotype correl…
Water Resource Recovery Facilities (WRRFs): The Case Study of Palermo University (Italy)
2021
The wastewater sector paradigm is shifting from wastewater treatment to resource recovery. In addition, concerns regarding sustainability during the operation have increased. In this sense, there is a need to break barriers (i.e., social, economic, technological, legal, etc.) for moving forward towards water resource recovery facilities and demonstration case studies can be very effective and insightful. This paper presents a new water resource recovery case study which is part of the Horizon 2020 EU Project “Achieving wider uptake of water-smart solutions—Wider Uptake”. The final aim is to demonstrate the importance of a resource recovery system based on the circular economy concept. The r…
Roadmapping the Transition to Water Resource Recovery Facilities: The Two Demonstration Case Studies of Corleone and Marineo (Italy)
2022
The current exploitation of freshwater, as well as the significant increase in sewage sludge production from wastewater treatment plants (WWTPs), represent nowadays a critical issue for the implementation of sustainable development consistent with the circular economy concept. There is an urgent need to rethink the concept of WWTPs from the conventional approach consisting in pollutant removal plants to water resource recovery facilities (WRRFs). The aim of this paper is to provide an overview of the demonstration case studies at the Marineo and Corleone WRRFs in Sicily (IT), with the final aim showing the effectiveness of the resources recovery systems, as well as the importance of plant o…
Gully Erosion Susceptibility Mapping Using Multivariate Adaptive Regression Splines—Replications and Sample Size Scenarios
2019
Soil erosion is a serious problem affecting numerous countries, especially, gully erosion. In the current research, GIS techniques and MARS (Multivariate Adaptive Regression Splines) algorithm were considered to evaluate gully erosion susceptibility mapping among others. The study was conducted in a specific section of the Gorganroud Watershed in Golestan Province (Northern Iran), covering 2142.64 km2 which is intensely influenced by gully erosion. First, Google Earth images, field surveys, and national reports were used to provide a gully-hedcut evaluation map consisting of 307 gully-hedcut points. Eighteen gully erosion conditioning factors including significant geoenvironmental and morph…
A posteriori error estimates for Webster's equation in wave propagation
2015
We consider a generalised Webster’s equation for describing wave propagation in curved tubular structures such as variable diameter acoustic wave guides. Webster’s equation in generalised form has been rigorously derived in a previous article starting from the wave equation, and it approximates cross-sectional averages of the propagating wave. Here, the approximation error is estimated by an a posteriori technique. peerReviewed
Revisión de la sección del yacimiento del Mas de la Chimenea Alta (Formación Arcillas de Morella, Castellón) y significado en el contexto paleoambien…
2012
Desde los primeros estudios estratigráficos y paleontológicos, que datan de principios del siglo XX, la Fm Morella se ha caracterizado por su coloración rojiza y su contenido fósil. La mayor parte de sus depósitos se han interpretado como continentales, aunque con intercalaciones locales de materiales marinos. En esta unidad se da la paradoja de que muchos de los lugares descritos con fauna de vertebrados continentales se encuentran en depósitos interpretados como ambientes marinos poco profundos y de transición. La sección del Mas de la Chimenea Alta es un ejemplo. Ésta contiene yacimientos con fósiles de vertebrados que son claramente alóctonos, pero también otros, con icnitas que permite…
How costly are debt crises?
2011
The aim of this paper is to assess the short- and medium-term impact of debt crises on GDP. Using an unbalanced panel of 154 countries from 1970 to 2008, the paper shows that debt crises produce significant and long-lasting output losses, reducing output by about 10 percent after eight years. The results also suggest that debt crises tend to be more detrimental than banking and currency crises. The significance of the results is robust to different specifications, identification and endogeneity checks, and datasets.
Man's strategy in domestication - a synthesis of new research trends.
1976
The minimum brain size possible in the relevant wild species and certain colour types which, because of alterations in the neurotransmitter system caused by the respective colour genes, are related to behavioural traits diverging from the wild animal's norm appear to be first-rate bases for domestication either separately or in combination.
Cervico-Oculo-Acusticus (Wildervanck's) syndrome: a clinical variant of Klippel-Feil sequence?
1990
A 7-year-old female child with phenotype of Cervico-Oculo-Acousticus (Wildervanck's) syndrome is presented. In addition to fusion of multiple cervical vertebrae with short neck, abducens nerve palsy and deafness, the child showed severe growth and bone delay, renal abnormalities and slight mental retardation. The presence of such malformations seems to suggest that Wildervanck's syndrome is a clinical variant of Klippel-Feil sequence. Both conditions usually have sporadic occurrence with female prevalence, more consistent for cervico-oculo-acousticus syndrome. The possibility of dominant inheritance has been postulated for both, autosomal for Klippel-Feil, autosomal or X-linked with lethali…