Search results for " DOM"
showing 10 items of 2750 documents
Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs.
2018
Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)a and IFN? and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activit…
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.
Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs
2019
Abstract The T cell repertoire is composed of T cell receptors (TCR) selected by their cognate MHC-peptides and naive TCR that do not bind known peptides. While the task of distinguishing a peptide-binding TCR from a naive TCR unlikely to bind any peptide can be performed using sequence motifs, distinguishing between TCRs binding different peptides requires more advanced methods. Such a prediction is the key for using TCR repertoires as disease-specific biomarkers. We here used large scale TCR-peptide dictionaries with state-of-the-art natural language processing (NLP) methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific classifier to predict which TCR binds to which…
The care pathway for children with urticaria, angioedema, mastocytosis
2015
Cutaneous involvement characterized by urticarial lesions with or without angioedema and itch is commonly observed in routine medical practice. The clinical approach may still remain complex in real life, because several diseases may display similar cutaneous manifestations. Urticaria is a common disease, characterized by the sudden appearance of wheals, with/without angioedema. The term Chronic Urticaria (CU) encompasses a group of conditions with different underlying causes and different mechanisms, but sharing the clinical picture of recurring wheals and/or angioedema for at least 6 weeks. Hereditary Angioedema (HAE) is a rare disorder characterized by recurrent episodes of non-pruritic,…
Purísima 3: un ejemplo de villa periurbana en "Valentia"
2017
espanolEste articulo tiene como objetivo mostrar los restos ineditos de un espacio domestico situado en los suburbia de Valentia, a menos de 1 km del pomoerium, de caracteristicas unicas en la ciudad. Se trata de una serie de estancias pavimentadas con mosaicos de opus tessellatum, decorados con motivos geometricos y vegetales bicromos de gran calidad. Destaca la presencia de un peristilo trapezoidal como espacio redistribuidor. En suma, se trata de un interesante ejemplo de arquitectura privada periurbana, cuya situacion responde al desarrollo de los suburbia, poco estudiados en el ambito valenciano. EnglishThis paper aims to show the inedit rests of a suburban domestic space found in Vale…
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…
Artemisinin–Second Career as Anticancer Drug?
2015
Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general. Its isolation from Sweet Wormwood (qinhao, Artemisia annua L.) represents the starting point for an unprecedent success story in the treatment of malaria worldwide. Beyond the therapeutic value against Plasmodium parasites, it turned out in recent years that the bioactivity of artemisinin is not restricted to malaria. We and others found that this sesquiterpenoid also exerts profound anticancer activity in vitro and in vivo. Artemisinin-type drugs exert multi-factorial cellular and molecular actions in cancer cells. Ferrous iron …
Bathymetry time series using high spatial resolution satellite images
2020
The use of the new generation of remote sensors, such as echo sounders and Global Navigation Satellite System (GNSS) receivers with differential correction installed in a drone, allows the acquisition of high-precision data in areas of shallow water, as in the case of the channel of the Encañizadas in the Mar Menor lagoon. This high precision information is the first step to develop the methodology to monitor the bathymetry of the Mar Menor channels. The use of high spatial resolution satellite images is the solution for monitoring many hydrological changes and it is the basis of the three-dimensional (3D) numerical models used to study transport over time, environmental variability, and wa…
A Self-Contained and Automated Method for Flood Hazard Maps Prediction in Urban Areas
2020
Water depths and velocities predicted inside urban areas during severe storms are traditionally the final result of a chain of hydrologic and hydraulic models. The use of a single model embedding all the components of the rainfall&ndash
Estimating Human Impacts on Soil Erosion Considering Different Hillslope Inclinations and Land Uses in the Coastal Region of Syria
2020
Soils in the coastal region of Syria (CRoS) are one of the most fragile components of natural ecosystems. However, they are adversely affected by water erosion processes after extreme land cover modifications such as wildfires or intensive agricultural activities. The main goal of this research was to clarify the dynamic interaction between erosion processes and different ecosystem components (inclination, land cover/land use, and rainy storms) along with the vulnerable territory of the CRoS. Experiments were carried out in five different locations using a total of 15 erosion plots. Soil loss and runoff were quantified in each experimental plot, considering different inclinations and land u…