Search results for " DOM"

showing 10 items of 2750 documents

Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.

2021

The proteomic analysis was performed at the proteomics facility of SCSIE, University of Valencia (Burjassot, Spain) that belongs to ProteoRed, PRB2-ISCIII, Madrid, Spain. We also thank Dr. Tatiana Corey, Dr. Amy Beierschmitt and Dr. Pompei Bolfa for their support during sample collection.

ADULT WORMSSerum ProteinsProteomePhysiologyProteomesEggsRC955-962Egg proteinBiochemistryHeat Shock ResponseMedical ConditionsReproductive PhysiologyArctic medicine. Tropical medicineINFECTIONChlorocebus aethiopsMedicine and Health SciencesSUPEROXIDE-DISMUTASECellular Stress ResponsesImmune System ProteinsbiologySoil-transmitted helminthiasisHelminth ProteinsNEMATODEBird EggsInfectious DiseasesTrichurisCell ProcessesHelminth InfectionsProteomeFemaleAntibodyPublic aspects of medicineRA1-1270EXCRETORY-SECRETORY PRODUCTSResearch ArticleNeglected Tropical DiseasesTrichuriasisImmunologyMicrobiologyVitellogeninProtein Domainsparasitic diseasesmedicineParasitic DiseasesHEAT-SHOCK PROTEINSAnimalsHumansTrichuriasisPARASITEOvumImmunodiagnosticsMOLECULAR-CLONINGIDENTIFICATIONPublic Health Environmental and Occupational HealthBiology and Life SciencesProteinsMASS-SPECTROMETRYCell Biologymedicine.diseasebiology.organism_classificationTropical DiseasesSoil-Transmitted HelminthiasesAntigens Helminthbiology.proteinTrichuris trichiuraPLoS Neglected Tropical Diseases
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The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?

2002

International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …

AERES A Economie Gestion - CoNRS37-R2 - EconLitspatial dependence0211 other engineering and technologies02 engineering and technologyjel:C21Gross domestic productconvergence club convergence spatial econometrics European regions spatial regimes spatial autocorrelation050602 political science & public administrationEconometricsEconomics[ SHS.ECO ] Humanities and Social Sciences/Economies and financesGrowth rateSpatial dependence[SHS.ECO] Humanities and Social Sciences/Economics and FinanceSpatial analysisComputingMilieux_MISCELLANEOUSGeneral Environmental ScienceConvergence clubsconvergence05 social sciencesjel:C51General Social Sciences021107 urban & regional planningConvergence (economics)[SHS.ECO]Humanities and Social Sciences/Economics and Financespatial regimes0506 political scienceSpatial heterogeneityspatial econometricsSpatial econometricsjel:R11geographic spilloversjel:R15
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GENETIC DISTINCTIVENESS OF ITALIAN AUROCHS: NEW INSIGHT NTO CATTLE DOMESTICATION PROCESS

2008

ANCIENT DNA BOS PRIMIGENIUS DOMESTICATION MEDITERRANEAN SEASettore BIO/08 - Antropologia
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Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Moll…

2011

Since sponges, as typical filter-feeders, are exposed to a high load of attacking prokaryotic and eukaryotic organisms, they are armed with a wide arsenal of antimicrobial/cytostatic low-molecular-weight, non-proteinaceous bioactive compounds. Here we present the first sponge agent belonging to the group of ASABF-type antimicrobial peptides. The ASABF gene was identified and cloned from the demospongeSuberites domuncula. The mature peptide, with a length of 64 aa residues has a predicted pI of 9.24, and comprises the characteristic CSαβ structural motif. Consequently, the S. domuncula ASABF shares high similarity with the nematode ASABFs ; it is distantly related to the defensins. The recom…

ASABFAntimicrobial peptidesGastropodaMolecular Sequence DataPharmaceutical SciencePeptideMicrobial Sensitivity TestsGram-Positive BacteriaReal-Time Polymerase Chain ReactionArticleMicrobiology03 medical and health sciencesantimicrobial peptidesAnti-Infective AgentsSequence Analysis ProteinDrug DiscoveryAnimalsBittium sp.Structural motiflcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)spongesPhylogeny030304 developmental biologychemistry.chemical_classification0303 health sciencesbiology030306 microbiologyEffectorHemolytic AgentsapoptosisGeologyBittium spsponges; <em>Suberites domuncula</em>; ASABF; antimicrobial peptides; apoptosis; <em>Bittium</em> sp.biology.organism_classificationSuberites domunculasponges ; Suberites domuncula ; ASABF ; antimicrobial peptides ; apoptosis ; Bittium sp.Recombinant ProteinsSuberites domunculaSpongeEnzymelcsh:Biology (General)chemistryMolluscaSuberitesSuberitesAntimicrobial Cationic PeptidesMarine Drugs
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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HETEROGENITY OF AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA IN SICILY

2004

AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIAMUTATIONSEPIDEMIOLOGY
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Plēsonīgo cenu jēdziens Latvijas konkurences tiesībās

2015

Plēsonīgo cenu stratēģijas realizēšana Latvijas doktrīnā līdz šim nav apskatīta. Lielākā problēma, kas saistīta ar plēsonīgajām cenām, ir plēsonīgo cenu piemērošanas nošķiršana no ikdienišķas biznesa prakses. Eiropas Savienības doktrīnā un Eiropas Savienības Tiesas praksē ir nostiprināti dažādi kritēriji, meklējot risinājumu iepriekš minētajai problēmai. Autors pētījuma gaitā analizē plēsonīgo cenu jēdzienu, kā arī Eiropas Savienības Tiesas praksi un tās piedāvātos kritērijus plēsonīgo cenu piemērošanas identificēšanai. Tāpat darba gaitā autors salīdzina Konkurences padomes nolēmumos nostiprinātos kritērijus ar Eiropas Savienības Tiesas praksi. Darbā, cita starpā, autors analizē arī Amerika…

Abuse of dominant positionAKZOPredatory pricingPlēsonīgās cenasDominējošā stāvokļa ļaunprātīga izmantošanaJuridiskā zinātne
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La Corte di giustizia rinviene una fattispecie che si assumeva perduta: l'abuso di struttura

2023

The article provides an analysis on the relationship between Article 102 TEUF (and its scope) and EU Regulation No 139/04 on mergers

Abuse of dominant positionSettore IUS/14 - Diritto Dell'Unione Europea
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Optimal Damping Constant Investigation on a Quarter-Car

2013

This paper shows an investigation on optimal damping constant performed in the frequency domain. The optimal damping constant is meant as that value that minimizes the acceleration of all connected bodies characterizing a two degree of freedom system sketching a quarter car. The connected bodies are sprung and unsprung mass respectively for quarter of chassis and tire, this last keeps the contact with the ground and it is connected with the sprung mass through a shock absorber characterized by spring and fluid damper. Optimal damping constant was determined by imposing analytical conditions on the expression of acceleration of two masses. Afterwards, the variation of acceleration and positi…

AccelerationShock absorberChassisSpring (device)Frequency domainMathematical analysisSprung massUnsprung massMathematicsDamper
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The N-terminal domain of the light-harvesting chlorophyll a/b-binding protein complex (LHCII) is essential for its acclimative proteolysis.

2000

AbstractVariations in the amount of the light-harvesting chlorophyll a/b-binding protein complex (LHCII) is essential for regulation of the uptake of light into photosystem II. An endogenous proteolytic system was found to be involved in the degradation of LHCII in response to elevated light intensities and the proteolysis was shown to be under tight regulation [Yang, D.-H. et al. (1998) Plant Physiol. 118, 827–834]. In this study, the substrate specificity and recognition site towards the protease were examined using reconstituted wild-type and mutant recombinant LHCII. The results show that the LHCII apoprotein and the monomeric form of the holoprotein are targeted for proteolysis while t…

Acclimative proteaseChlorophyll aN-terminal domainPhotosystem IImedicine.medical_treatmentProteolysisMutantMolecular Sequence DataPhotosynthetic Reaction Center Complex ProteinsBiophysicsLight-Harvesting Protein ComplexesRecognition siteEndogenyLight-harvesting complex IIBiochemistrylaw.inventionchemistry.chemical_compoundStructural BiologylawSpinacia oleraceaGeneticsmedicineAmino Acid SequenceMolecular BiologyProteasemedicine.diagnostic_testSequence Homology Amino AcidChemistryBinding proteinHydrolysisPhotosystem II Protein ComplexCell BiologyBiochemistryRecombinant light-harvesting complex IIProteolysisRecombinant DNAFEBS letters
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