Search results for " Damage"

Using exomarkers to assess mitochondrial reactive species in vivo

2014

Background:\ud The ability to measure the concentrations of small damaging and signalling molecules such as reactive oxygen species (ROS) in vivo is essential to understanding their biological roles. While a range of methods can be applied to in vitro systems, measuring the levels and relative changes in reactive species in vivo is challenging.\ud \ud Scope of review:\ud One approach towards achieving this goal is the use of exomarkers. In this, exogenous probe compounds are administered to the intact organism and are then transformed by the reactive molecules in vivo to produce a diagnostic exomarker. The exomarker and the precursor probe can be analysed ex vivo to infer the identity and a…

Guided Wave Techniques for Damage Detection in Composite Aerospace Structures

2018

Composite materials make up an increasing portion of today’s aerospace structures (see, e.g. Boeing 787 and Airbus 380). These aircrafts’ fuselage, for example, is composed of a laminated composite skin connected to composite stringers and C-frames. Of primary importance is the detection of damage in these built-up structures, whether caused by the manufacturing process or in service (e.g. impacts). A related issue is the characterization of the composite (visco)elastic mechanical properties, that can also be related to the quantification of potential damage. Guided elastic waves propagating in the ~100s kHz regime lend themselves to provide the necessary sensitivity to these two conditions…

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

2021

AbstractIron is a fundamental nutrient utilized by living cells to support several key cellular processes. Despite its paramount role to sustain cell survival, excess of labile iron availability can inflict severe cell damage via reactive oxygen species generation which, in turn, can promote neoplastic transformation. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tensions herein present. Moreover, cigarette smoke as well as air pollution particulate can function as vehicles of iron supply, leading to an iron dysregulation condition shown to be crucial in the pathogenesis of several respiratory diseases including lung cancer. Hephaestin (HEPH) bel…

Browsing hinders the regeneration of broadleaved trees in uneven-aged forest management in southern Finland

2020

Uneven-aged forest management has attained increasing popularity. It may benefit biodiversity, buffer against pests and abiotic damages, decrease runoff from clearcuts and improve recreational values. We studied how gap cuttings and single-tree selection cuttings influence browsing damage in spruce-dominated forests in south-central Finland. Overall, browsing damage was especially frequent in aspen and rowan, but also in birch. The larger the basal area left in harvesting, the lower the browsing pressure on birch and rowan; neither the harvesting method nor the seedling density had an independent effect on browsing damage. Although larger tree retention levels may reduce browsing damage, th…

Reflexiones sobre la concurrencia de violencia económica en el contexto de familia : impacto y mecanismos para su neutralización

2021

Through this work we carry out a dissertation on the phenomenon of economic violence, as a manifestation of gender violence, in the family context, and, especially, from the perspective of the divorce framework. We will analyze the harmful effects that it produces, the damage that it triggers on the most basic and essential interests of the family, and its use as a control mechanism by the aggressors. In addition to a vision of the different mechanisms that, enshrined in our legal system, serve to distort it.

The interphase elasto-plastic damaging model applied to masonry structures

2012

Heterogeneous structures studied by interphase elasto-damaging model.

2011

For all structures that are constituted by heterogeneous materials, the meso-modelling approach is the most rigorous since it analyzes such structures as an assembly of distinct elements connected by joints, the latter commonly simulated by apposite interface models. In particular, the zero-thickness interface (ZTI) models are extensively used in those cases where the joint thickness is small if compared to the other dimensions of the heterogeneosu material. In ZTI models the constitutive laws relate the contact tractions to the displacement discontinuities at the interface, but in many cases the joint response depends also on internal stresses and strains within the bulkmaterial. In this s…

Changes in Muscle Activity Patterns and Joint Kinematics During Gait in Hemophilic Arthropathy

2020

Hemophilic arthropathy is the result of repetitive intra-articular bleeding and synovial inflammation. In people with hemophilic arthropathy (PWHA), very little is known about the neural control of individual muscles during movement. The aim of the present study was to assess if the neural control of individual muscles and coordination between antagonistic muscle pairs and joint kinematics during gait are affected in PWHA. Thirteen control subjects (CG) walked overground at their preferred and slow velocity (1 m/s), and 14 PWHA walked overground at the preferred velocity (1 m/s). Joint kinematics and temporal gait parameters were assessed using four inertial sensors. Surface electromyograph…

NEURAL CONTROL OF GAIT IN PEOPLE WITH HAEMOPHILIC ARTHROPATHY

2022

La hemofilia es un trastorno hemorrágico causado por una deficiencia de los factores VIII o IX de la coagulación. Las personas con hemofilia grave pueden tener hemorragias espontáneas o hemorragias en respuesta a traumatismos menores; la mayoría de los eventos ocurren en las articulaciones y los músculos. La manifestación clínica más frecuente es la artropatía hemofílica, que resulta del sangrado intraarticular repetitivo y de la membrana sinovial inflamada, lo que puede resultar en dolor crónico y deterioro articular. El objetivo general de mi tesis fue investigar el control neural de la marcha en personas con artropatía hemofílica (PCAH). La hipótesis de mi tesis fue que control neural de…

Usefulness of biomarkers as intermediate endpoints in health risks posed by occupational lead exposure

2015

The article concerns potential harmful effects of exposure to lead. Although the occurrence of severe lead poisoning has receded in several countries, occupational exposure resulting in moderate and clinically symptomatic toxicity is still common. An earlier and precise characterization of an individual response is obligatory in order to assess the possible risks for human health. Biomarkers may fill important gaps in the path from exposure to a disease. Specifically speaking, emerging (DNA double strand breaks and telomeric DNA erosion) and validated (micronuclei induction and chromosomal aberrations) biomarkers of genotoxicity seem to provide evidence for the assessment of molecular and c…