Search results for " Damage"

showing 10 items of 1139 documents

Systematic comparison of Artificial Neural Networks for a SHM procedure applied to Composite Structure

2014

The problems related to damage detection represents a primary concern, particularly in the framework of composite structure. In fact, for this kind of structures barely visible damage can occur. Moreover, one of the major in-service damage of composite aircraft strcutures is represented by disbonds between the stiffeners and the skin undergoing dynamic or post-buckling loads. The effective implementation of a SHM system relies on the synthesis of non-destructive technique (NDT), fracture mechanics, sensors technology, data manipulation and signal processing, and it can receive a great improvement through the use of an Artificial Neural Networks. Different architectures of Artificial Neural …

Structural Health MonitoringComposite damageSettore ING-IND/04 - Costruzioni E Strutture AerospazialiNeural network
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Assessment of Modelling Structure and Data Availability Influence on Urban Flood Damage Modelling Uncertainty

2014

Abstract In modelling application, different model structures may be equally reliable in terms of calibration ability but they may produce different uncertainty levels; moreover, available data during model calibration may influence the uncertainty linked to the predictions of the same modelling structure. In the present paper, Bayesian model-averaging was applied to several flood damage estimation models in order to identify the best model combination for urban flooding distribution analysis in Palermo city center (Italy). During the analysis, was taken into account the effect of the available data growth on the model uncertainty with respect to the different combination of models outputs.

Structure (mathematical logic)Flood mythCalibration (statistics)flooding damage evaluationBayesian probabilityFlooding (psychology)General MedicineData availabilityBayesian Model-AveragingEconometricsEnvironmental scienceSensitivity analysisuncertainty analysis.Engineering(all)Uncertainty analysisProcedia Engineering
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Cerebral expression of neuroglobin and cytoglobin after deep hypothermic circulatory arrest in neonatal piglets

2010

Deep hypothermic circulatory arrest (DHCA) is used in corrective cardiac surgery for complex congenital heart disease. Endogenous protective mechanisms may be responsible for the prevention of brain damage after hypothermic ischemia. Neuroglobin and cytoglobin are expressed in brain cells and appear to modulate hypoxic-ischemic brain injury. However, their neuroprotective potency is still not understood. Thus the aim of this study was to detect the influence exerted by DHCA on their expression.The effects of DHCA were analyzed in a neonatal piglet model with cardiopulmonary bypass, DHCA of 60 and 120 min and subsequent reperfusion of 6h. Complete histological analysis and changes in the mRN…

Sus scrofaCentral nervous systemIschemiaNeuroglobinNerve Tissue ProteinsBrain damageBiologyPharmacologyNeuroprotectionmedicineAnimalsMolecular BiologyGeneral NeuroscienceCytoglobinCytoglobinBrainHypothermiamedicine.diseaseGlobinsCirculatory Arrest Deep Hypothermia InducedDisease Models Animalmedicine.anatomical_structureAnimals NewbornNeuroglobinAnesthesiaHypoxia-Ischemia BrainNerve DegenerationDeep hypothermic circulatory arrestNeurology (clinical)medicine.symptomDevelopmental BiologyBrain Research
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THE ILVA DISASTER: A STUDY OF ENVIRONMENTAL LIABILITY IN ITALY

2021

Purpose The purpose of this paper is to propose a reflection on the importance of individual environmental protection, which recognizes the right of every citizen to take action to obtain compensation for environmental damage, as a damage to his or her existential condition. One of the most discussed environmental issues in Italy today is the lack of personal protection because the European legislator has provided for a public protection of environmental damage. Design/methodology/approach Design/methodology/approach based on the analysis of a well-known environmental disaster, the case of ex Ilva, the author shows how in Italy there is a dangerous lack of protection in environmental matte…

Sustainable developmentEnvironment personal damage commons existential damage sustainable development050208 finance0502 economics and business05 social sciencesSettore IUS/01 - Diritto PrivatoEnvironmental liability050201 accountingBusinessCommonsLawGeneral Economics Econometrics and FinanceEnvironmental planning
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Inflammation in Ischemic Stroke Subtypes

2011

Determining the cause of stroke does influence choices for management. categorization of subtypes of ischemic stroke has had considerable study, but definitions are hard to formulate and their application for diagnosis in an individual patient is often problematic. Cerebral ischemia initiates a complex cascade of events at genomic, molecular, and cellular levels, and inflammation is important in this cascade. In 1993 for For the Trial of Org 10172 in Acute Stroke Treatment (TOAST), Adams et al] conducted a placebo-controlled, randomized, blinded study of the low-molecular-weight heparinoid given to patients within 24 hours after stroke and developed a system for diagnosis of subtype of isch…

TOAST Classificationmedicine.medical_specialtySettore MED/09 - Medicina InternaIschemiaInflammationstroke subtype stroke TOASTBrain damageSeverity of Illness IndexBrain IschemiaInternal medicineOutcome Assessment Health CareDrug DiscoverySeverity of illnessmedicineAnimalsHumanscardiovascular diseasesStrokeInflammationPharmacologyInterleukin-6business.industrymedicine.diseaseSurgeryStrokeVenous thrombosisC-Reactive ProteinSubtypes ischemic stroke TOASTEtiologyCardiologyCytokinesmedicine.symptombusinessCurrent Pharmaceutical Design
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Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.

2014

This is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.

TelomeraseDNA repairDNA damagelcsh:MedicineCell Cycle ProteinsComputingMilieux_LEGALASPECTSOFCOMPUTINGBiologyTransfectionBioinformaticsmedicine.disease_causeBiochemistryDyskeratosis CongenitaDyskerinCell LineMiceHeterochromatinMolecular Cell BiologyMedicine and Health SciencesmedicineAnimalsHumanslcsh:ScienceMutationMultidisciplinarylcsh:RBiology and Life SciencesNuclear ProteinsCell BiologyHematologyGenetic TherapyTransfectionTelomeremedicine.diseaseTelomereCell biologyOxidative StressGene Expression Regulationlcsh:QPeptidesDyskeratosis congenitaResearch ArticleDNA DamagePLoS ONE
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Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.

2020

Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…

TelomeraseProtein Folding:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::DNA-Binding Proteins::Rad52 DNA Repair and Recombination Protein [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins [Medical Subject Headings]Gene ExpressionYeast and Fungal ModelsArtificial Gene Amplification and ExtensionQH426-470BiochemistryPolymerase Chain ReactionChromosome conformation captureHistonesCromatina0302 clinical medicineSirtuin 2Macromolecular Structure AnalysisSilent Information Regulator Proteins Saccharomyces cerevisiaeCellular Senescence:Organisms::Eukaryota::Fungi::Yeasts::Saccharomyces::Saccharomyces cerevisiae [Medical Subject Headings]0303 health sciencesChromosome BiologyEukaryota:Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication [Medical Subject Headings]TelomereSubtelomere:Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Telomere [Medical Subject Headings]Chromatin3. Good healthChromatinCell biologyNucleic acidsTelomeres:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Telomere Homeostasis [Medical Subject Headings]Experimental Organism SystemsDaño del ADNEpigeneticsResearch ArticleSenescenceDNA Replication:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases::Histone Deacetylases [Medical Subject Headings]Chromosome Structure and FunctionProtein StructureSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeBiologyResearch and Analysis MethodsHistone DeacetylasesChromosomes03 medical and health sciencesSaccharomycesModel Organisms:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Sirtuins::Sirtuin 2 [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins::Silent Information Regulator Proteins Saccharomyces cerevisiae [Medical Subject Headings]DNA-binding proteinsGenetics:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Recombinases::Rec A Recombinases::Rad51 Recombinase [Medical Subject Headings]Molecular Biology TechniquesMolecular Biology030304 developmental biologyCromosomasSenescencia celularOrganismsFungiBiology and Life SciencesProteinsTelomere HomeostasisCell BiologyDNAMethyltransferasesG2-M DNA damage checkpointProteína recombinante y reparadora de ADN Rad52YeastTelomereRad52 DNA Repair and Recombination ProteinRepressor ProteinsAnimal Studies:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Transcription Factors::Repressor Proteins [Medical Subject Headings]DNA damageRad51 RecombinaseHomologous recombination030217 neurology & neurosurgeryTelómeroDNA DamagePLoS Genetics
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La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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Interventistica eco-guidata per l’articolazione d’anca

2013

Lo scopo di questo lavoro è di rivedere le principali applicazioni della interventistica eco-guidata d’anca, descrivendone le indicazioni e la metodologia. L’ecografia è una metodica considerata sicura per i pazienti, in quanto non è stato dimostrato un possibile danno dovuto all’energia trasmessa dagli ultrasuoni ai tessuti del paziente, contrariamente alle metodiche che fanno uso di radiazioni ionizzanti, come la radiografia convenzionale e la tomografia computerizzata. Inoltre, l’ecografia risulta rapida ed efficace nel guidare l’ago verso la sede voluta evitando di intercettare strutture vascolari e/o nervose, consentendo quindi una maggiore sicurezza, rispetto alle tecniche interventis…

The purpose of this work is to review the main applications of ultrasound-guided hip intervention al procedures describing the indications and methodology. Ultrasound is a method considered safe for patients as it has not been shown a possible damage due to ultrasound energy transmitted towards the patient's tissues as opposed to methods that make use of ionizing radiation such as conventional radiography and computed tomography. In addition ultrasound is quick and effective in guiding the needle to the desired location avoiding vascular and/or nerve structures thus enabling greater security compared to the techniques performed in interventional fluoroscopy which also have the disadvantage of a large delivery of ionizing radiation for both patient and operator. Several authors have described the main techniques of ultrasound-guided hip intervention and its various applications that can be both diagnostic (as in the case of joint fluid aspiration to assess the presence or absence of septic arthritis) and therapeutic (as in the case of drugs inoculations or evacuation of exceeding intra-articular fluid).
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Oxidative DNA damage and disturbance of antioxidant capacity by alternariol in Caco-2 cells

2015

Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the enzymes involved in the redox system, causing damage to cellular macromolecules such as DNA. The aims of this work were to determine the induction of oxidative stress by the antioxidant defenses imbalance in relation to glutathione (GSH), glutathione reductase (GR), glutathione transferase (GST), glutathione peroxidase (GPx) levels and DNA damage in Caco-2 cells derived from adenocarcinoma human colon. Oxidativ…

Time FactorsAntioxidantDNA damagemedicine.medical_treatmentGlutathione reductaseAlternariolBiologyToxicologymedicine.disease_causeAntioxidantsLactoneschemistry.chemical_compoundmedicineHumansGlutathione Transferasechemistry.chemical_classificationGlutathione PeroxidaseDose-Response Relationship DrugGlutathione peroxidaseGeneral MedicineGlutathioneMycotoxinsGlutathioneComet assayOxidative StressGlutathione ReductaseBiochemistrychemistryComet AssayCaco-2 CellsOxidative stressDNA DamageToxicology Letters
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