Search results for " Damage"
showing 10 items of 1139 documents
Le réchauffement climatique diminue-t-il le risque de dégâts par le gel pour les cultures de climat tempéré ?
2014
Does global warming reduce the freezing injury risk to temperate climate crops? Winter crop response to a temperature increase is complex. Recent works point out, for cold climate vegetation, a paradoxical increase in freezing injury in a warming climate. Complementary works are needed to support these results for winter crops in temperate areas. To achieve this goal, five climatic records spanning a fifty years-long period for both daily minimum and maximum temperatures were analyzed with a model predicting frost hardiness and freezing damage for the winter pea crop. The methodological approach was based on three main steps: 1) the climate warming analysis of the 1987/1988 temperature shif…
Tracking Ideal Varieties and Cropping Techniques for Agroecological Weed Management: A Simulation-Based Study on Pea.
2022
Book of abstract p.110-111; International audience; Pea (Pisum sativum L.) is a key diversification crop but current varieties are not verycompetitive against weeds. The objective of this study was to identify, depending on the typeof cropping system and weed flora, (1) the key pea parameters that drive crop production,weed control and weed contribution to biodiversity, (2) optimal combinations of peaparameter values and crop-management techniques to maximise these goals. For this, virtualexperiments were run, using FLORSYS, a mechanistic simulation model (Colbach et al., 2021,Field Crops Res 261:108006). This individual-based 3D model simulates daily crop-weed seedand plant dynamics over t…
Pricing the homebuyer's countryside view
2008
In most developed nations big cities are expanding ever farther into the countryside. Rural populations are growing, whether with workers - commuters or the self-employed - retired people, or temporary residents. In France a "periurbanization" movement began in Ile-de-France in the 1960s and spread to the large provincial cities in the next decade before becoming a nationwide phenomenon (Le Jeannic 1997; Schmitt et al. 1998; Cavailhès and Schmitt 2002). So successful was this movement that by 1999 33% of the land area of France was periurban with 12.3 million people living there. Progression from 1990 to 1999 was remarkable, with the area concerned increasing by half (more than 6 million he…
Assessment of the toxicity of cholesterol oxides on retinal pigment epithelial cultured cells
2006
International audience; Purpose: Among the retinal lipid deposits found in AMD (age related macular degeneration), esterified and unesterified cholesterol have been identified. Cholesterol that accumulates in Bruch's membrane could be oxidized and lead to cholesterol oxides known as oxysterols. These compounds have cytotoxic activities on many vascular cell types, and we conducted this study to evaluate the cytotoxics effects of oxysterols on retinal pigment epithelial (RPE) cells. Methods: Human RPE cells (ARPE–19) were cultured and treated by 7–ketocholesterol (7–keto), 7–betahydroxycholesterol (7–beta) and 25–hydroxycholesterol (25–OH). ARPE–19 cells viability was determined with MTT ana…
DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), known to be more common in the elderly, who also show more severe symptoms and are at higher risk of hospitalization and death. Here, we show that the expression of the angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 cell receptor, increases during aging in mouse and human lungs. ACE2 expression increases upon telomere shortening or dysfunction in both cultured mammalian cells and in vivo in mice. This increase is controlled at the transcriptional level, and Ace2 promoter activity is DNA damage response (DDR)-dependent. Both pharmacological global DDR inhibition of ATM kin…
Il risarcimento del danno provocato dall’amministrazione nazionale per violazione della disciplina sulla qualità dell’aria: una questione ancora aper…
2023
La correlazione esistente tra inquinamento e godimento dei diritti umani appare, oggi giorno, chiara ed innegabile, ciò che invece appare decisamente più complesso è stabilire quali siano le conseguenze di questa correlazione sotto il profilo strettamente giuridico. Da un lato, infatti, occorre verificare se, ed eventualmente in che misura, gli effetti nocivi dell’inquinamento possano essere qualificati come violazioni dei diritti umani da sanzionare e risarcire. Dall’altro lato, è necessario chiarire se, ed eventualmente in che misura, gli effetti nocivi dell’inquinamento, in quanto qualificati come violazioni dei diritti umani, possano essere imputati allo Stato o ad altri enti pubblici c…
Exercise-induced changes in airway cells
2007
Synthesized benzamido derivatives exert antiproliferative effects by DNA damage and ROS generation.
2016
In this study we explored the effect and the biological action of synthesized benzamido derivatives bearing the (1S,2S)-2-phenyl-cyclopropane-1-carboxamido, 1,1'-biphen-2-carboxamido and 1,1'-biphen-4-carboxamido moieties on K562, a human leukemia cell line. Among the synthesized compounds a particular antiproliferative action was observed with the benzamido derivative bearing the 2-1,1'-biphenyl moiety with the substitution at the 5 position of the benzamido moiety with iodine. This compound showed cytotoxic effects in K562 leukemic cells at nanomolar concentrations and was, therefore, chosen as compound to explore its mode of action. Our analyses provided evidence that this benzamido deri…
Solvent-dependent hypsochromic shift in the imidazole based complex [Cu(µ2-SO4)(Im)4] and ameliorative effects on breast cancer-induced bone metastas…
2023
A sulfate-bridged complex [Cu(µ2-SO4)(Im)4] (1) was prepared and structurally characterized, where Im: imidazole. The X-ray structure analysis reveals that 1 crystallizes in the monoclinic system with space group C2/c. The octahedral coordination around the metal center is made up of four distinct imine nitrogen atoms in the equatorial plane, and two sulfate oxygen atoms occupying the axial sites. The covalent linkage between metals via the sulfate group, forming infinite 1D zigzag chains, ensures the entanglement of the structure. These chains, in turn, are further assembled into a 2D network through N-H...O hydrogen bonding. Thermal analyses underline the high thermal stability of our com…
Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review
2020
Free radicals produced during exercise play a role in modulating cell signaling pathways. High doses of antioxidants may hamper adaptations to exercise training. However, their benefits are unclear. This review aims to examine whether vitamin C (VitC) and/or vitamin E (VitE) supplementation (SUP) prevents exercise-induced muscle damage. The PubMed, Web of Science, Medline, CINAHL, and SPORTDiscus databases were searched, and 21 articles were included. Four studies examined the effects of acute VitC SUP given pre-exercise: in one study, lower CK levels post-exercise was observed; in three, no difference was recorded. In one study, acute VitE SUP reduced CK activity 1 h post-exercise in condi…