Search results for " Damage"

2021

The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) after a minimum of one-day rest from exercise and another one in a ‘non-recovered’ state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentration…

Post-acute COVID-19 neurological syndrome: a new medical 2 challenge

2021

In December 2019, inWuhan (China), a highly pathogenic coronavirus, named SARS-CoV-2, dramatically emerged. This new virus, which causes severe pneumonia, is rapidly spreading around the world, hence it provoked the COVID-19 pandemic. This emergency launched by SARS-CoV-2 also had, and still has, devastating socio-economic aspects. Assessing the impact of COVID-19 on vulnerable groups of people is crucial for the adaptation of governments' responses. Growing scientific evidence suggests that it is essential to keep the attention on people after acute SARSCoV- 2 infection; indeed, some clinical manifestations are frequently present even after recovery. There is consensus on the need to defin…

Aspetti valutativi nella costruzione del sistema informativo per la gestione ambientale dell'azienda

2013

This paper deals with the construction of an environmental management oriented corporate information system. A company point of view is adopted and a managerial approach is integrated with an evaluative approach. The work provides a critical reflection on the nature of corporate environmental responsibility and on the contribution of evaluation discipline for environment oriented improving of the traditional economic and financial corporate information system. Corporate management recognizes the principle that governs the activity of a company in the creation of economic value. In production processes, the neg-entropic aspects − relating to produced goods and other tangible and intangible b…

A New Wireless Device for Real-Time Mechanical Impact Evaluation in a Citrus Packing Line

2020

Abstract. Postharvest handling of fresh fruit is a potential source of bruising and damage, with significant consequences for fruit quality and marketability. In the last 30 years, different types of impact-recording devices (also called electronic fruits or pseudo-fruits) have been developed with the aim of measuring the impacts experienced by fruits during postharvest operations. The aim of this study was to develop and test a novel wireless instrumented sphere to study the critical points in a citrus packing line by measuring the impacts experienced by fruits in real-time. The non-commercial device was based on a MEMS (micro-electro-mechanical system) sensor node with a sensing range fro…

A damage identification procedure based on Hilbert transform: Experimental validation

2010

SUMMARY This paper aims at validating the feasibility of an identification procedure, based on the use of the Hilbert transform, by means of experimental tests for shear-type multi-degree-of-freedom systems. Particularly, a three-degree-of-freedom frame will be studied either numerically or experimentally by means of a laboratory scale model built at the laboratory of the Structural, Aerospace and Geotechnical Engineering Department (DISAG) of University of Palermo. Several damage scenarios have been considered to prove the effectiveness of the procedure. Moreover, the experimental tests have been conducted by considering two different input loads: pulse forces, simulated by means of an ins…

Hirnprotektion unter Notfallbedingungen: Sind Anästhetika neuroprotektiv?

1997

Glutamate Enhances Brain Damage from Ischemia and Trauma

1997

The amino acid glutamate is a model agent to demonstrate the significance of neurotoxic mediator compounds in secondary brain damage from trauma, ischemia or other adverse conditions. Intensive research of the role of mediator compounds is clinically worthwile as more specific forms of treatment may emerge for the benefit of afflicted patients. In view of the great number of factors, cytokines, etc., which could play a role, it is mandatory that a mediator function in secondary brain damage is identified according to the stringent requirements established for that purpose. Glutamate has been shown — as is the case for only a few other agents — to meet all the criteria of a mediator of secon…

New cerebral protection strategies.

2005

PURPOSE OF REVIEW This article presents an overview of the most recent and important strategies to reduce secondary brain damage. RECENT FINDING There is currently no magic bullet available to protect the brain after neuronal injury. This is related to the complex pathophysiology of cerebral ischemia, which makes it unlikely that a single pharmacological intervention results in sustained neuroprotection. Analyses of clinical studies reveal that acute physiologic derangements (e.g. fever, hypertension and hypotension, hypoxemia, hypercapnia, hyperglycemia) are the most important predictors of unfavorable outcome after brain injury and have to be treated. The effectiveness of anesthetic agent…

Immune pathogenesis of hepatitis A

1992

In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.

Endogenous Agents That Contribute to Generate or Prevent Ischemic Damage

2012

From single to multicellular organisms, protective mechanisms have evolved against endogenous and exogenous noxious stimuli. Over the past decades numerous signaling pathways by which the brain senses and reacts to such insults as neurotoxins, substrate deprivation and inflammation have been discovered. Research on preconditioning is aimed at understanding endogenous neuroprotection to boost it or to supplement its effectors therapeutically once damage to the brain has occurred, such as after stroke or brain trauma. Another goal of establishing preconditioning protocols is to induce endogenous neuroprotection in anticipation of incipient brain damage. Currently several endogenous neuroprote…