Search results for " Decline"
showing 10 items of 247 documents
The cognitive profile of prion disease: a prospective clinical and imaging study
2015
Objectives Prion diseases are dementing illnesses with poorly defined neuropsychological features. This is probably because the most common form, sporadic Creutzfeldt-Jakob disease, is often rapidly progressive with pervasive cognitive decline making detailed neuropsychological investigation difficult. This study, which includes patients with inherited, acquired (iatrogenic and variant) and sporadic forms of the disease, is the only large-scale neuropsychological investigation of this patient group ever undertaken and aimed to define a neuropsychological profile of human prion diseases. Methods A tailored short cognitive examination of all of the patients (n = 81), with detailed neuropsycho…
Faut-il réaliser un « Mini-Mental State Examination » chez tout sujet âgé hypertendu ?
2009
Hypertension constitutes a recognized risk factor of vascular dementia but also of Alzheimer-type dementia. Various longitudinal studies showed that midlife blood pressure level is one of the factors conditioning the onset of dementia syndrome in late life. The high risk of dementia is linked to leukoaraiosis, vascular rigidity, microcirculation disorders, oxidative stress, blood pressure fluctuations including orthostatic hypotension and strokes, all of those being associated with hypertension. Numerous clinical trials showed the positive effect of effective treatment of hypertension on the prevention of cognitive disorders and dementias. Thus, screening and early management of dementia an…
Mental health perspectives of Hunter syndrome: Case reports of two biological siblings
2016
Hunter syndrome is a rare X-linked recessive disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulphatase, leading to progressive accumulation of a substance called glycosaminoglycans in nearly all cell types, tissues, and organs. Hunter syndrome presents with facial dysmorphism, airway diseases, skeletal defects, cardiomyopathies, and neuropsychiatric manifestations. Mental subnormality is a cardinal feature in Hunter syndrome. This is a progressive cognitive decline that is not amenable to enzyme replacement therapy. Due to progressive cognitive decline, training the children to improve the adaptive functioning is a challenge that creates immense stress for the caregivers.…
Abrupt Alnus population decline at the end of the first millennium CE in Europe - The event ecology, possible causes and implications
2019
The study, based on the examination of 70 published and unpublished pollen profiles from Poland and supplementary data from the surrounding regions, shows that an abrupt, episodic Alnus population decline at the end of the first millennium CE was a much more widespread event than has been previously reported, spanning large areas of the temperate and boreal zones in Europe. The data from Poland suggest that the decline was roughly synchronous and most likely occurred between the 9th and 10th centuries, with strong indications for the 10th century. The pollen data indicate that human impacts were not a major factor in the event. Instead, we hypothesize that one or a series of abrupt climatic…
Moderate alcohol use and health: a consensus document
2013
Abstract Aims The aim of this consensus paper is to review the available evidence on the association between moderate alcohol use, health and disease and to provide a working document to the scientific and health professional communities. Data synthesis In healthy adults and in the elderly, spontaneous consumption of alcoholic beverages within 30 g ethanol/d for men and 15 g/d for women is to be considered acceptable and do not deserve intervention by the primary care physician or the health professional in charge. Patients with increased risk for specific diseases, for example, women with familiar history of breast cancer, or subjects with familiar history of early cardiovascular disease, …
Population Decline of the Capercaillie Tetrao urogallus aquitanicus in the Central Pyrenees
2020
El seguimiento a largo plazo de las aves amenazadas es esencial para estimar las tendencias poblacionales e identificar las posibles causas de declive, siendo particularmente importante en el caso de las aves alpinas que habitan en areas montanosas en los limites de su area de distribucion. Analizamos la tendencia poblacional del urogallo en los Pirineos centrales espanoles a partir de investigaciones realizadas entre 2000 y 2017. Encontramos un declive significativo de la poblacion (alrededor del 58%) en el numero de aves contadas en las areas de exhibicion (lek). la mayoria de los urogallos habitan bosques de coniferas de pino negro con una cobertura elevada de arandano y rododendro en el…
Residential Change and Socio-demographic Challenges for Large Housing Estates in Riga, Latvia
2019
Large housing estates from the socialist era are a characteristic feature of the built environment in the cities of Central and Eastern Europe. Many urban researchers are increasingly interested in residential changes in these areas, showing how demographic and socioeconomic processes interact with the decline or upgrading of this distinct type of housing. In Europe, the debate concerning large housing estates is largely related to a declining and ageing population, as well as to housing conditions. In Latvia, the underdeveloped housing market and the massive privatisation of the housing stock to sitting tenants have contributed, since the late-Soviet period, to inherited socio-spatial stru…
Cognitive impairment and stroke in elderly patients.
2016
Daniele Lo Coco,1 Gianluca Lopez,1 Salvatore Corrao,2,31Neurology and Stroke Unit, 2Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, 3Centre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S., University of Palermo, Palermo, Italy Abstract: We reviewed current knowledge about the interaction between stroke and vascular risk factors and the development of cognitive impairment and dementia. Stroke is increasingly recognized as an important cause of cognitive problems and has been implicated in the development of both Alzheimer's disease and vascular dementia. Th…
Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
2011
In recent years, there has been a growing interest, supported by a large number of experimental and epidemi-ological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes. Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces…
Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA
2018
Abstract: BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 14…