Search results for " Delay"

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000

Cancer–testis antigen NY-ESO-1 is one of the most immunogenic tumor antigens defined to date. Spontaneous humoral and CD8+ T-cell responses to NY-ESO-1 are detected in 40–50% of patients with advanced NY-ESO-1-expressing tumors. A clinical trial was initiated to study the immunological effects of intradermal vaccination with 3 HLA-A2-binding NY-ESO-1 peptides in 12 patients with metastatic NY-ESO-1-expressing cancers. Seven patients were NY-ESO-1 serum antibody negative, and five patients were NY-ESO-1 serum antibody positive at the outset of the study. Primary peptide-specific CD8+ T-cell reactions and delayed-type hypersensitivity responses were generated in four of seven NY-ESO-1 antibod…

Microcephaly and macrocephaly. A study on anthropometric and clinical data from 308 subjects

2019

Head circumference is the auxological parameter that most correlates with developmental anomalies in childhood. Head circumference (HC) two standard deviations (SD) below or above the mean defines microcephaly and macrocephaly, respectively. The aim of this retrospective study was to explore anthropometric parameters and clinical characteristics among subjects with abnormalities in HC who had been referred for developmental assessment. One hundred and sixty four subjects with microcephaly and 144 subjects with macrocephaly were enrolled from birth to 18 months of age. Head circumference at birth and the association with variables related to maternal health status, gestational age, growth pa…

LARGE FOR GESTATIONAL AGE, MACROSOMIA, OVERGROWTH: AN UPDATE ON DEFINITIONS AND DETERMINANTS

2020

Human growth and development, starting from conception, are characterized by a progressive increase in body and organ dimensions, as well as specific functional maturity, under the influence of genetic as well as environmental and epigenetic determinants. Beyond a possible normal familial trait, increased fetal growth resulting in a large for gestational age newborn, isolated macrosomia or that associated with congenital malformation, can be attributable to both maternal metabolic and genetic pathology. Overgrowth syndromes are a heterogeneous group of diseases characterized by excessive tissue development often concomitant to neurodevelopmental involvement. Recently, an increased risk of f…

A Generalization of Girod’s Bidirectional Decoding Method to Codes with a Finite Deciphering Delay

2012

In this paper we generalize an encoding method due to Girod (cf. [6]) using prefix codes, that allows a bidirectional decoding of the encoded messages. In particular we generalize it to any finite alphabet A, to any operation defined on A, to any code with finite deciphering delay and to any key x ∈ A+ , on a length depending on the deciphering delay. We moreover define, as in [4], a deterministic transducer for such generalized method. We prove that, fixed a code X ∈ A* with finite deciphering delay and a key x ∈ A *, the transducers associated to different operations are isomorphic as unlabelled graphs. We also prove that, for a fixed code X with finite deciphering delay, transducers asso…

Introduction

1998

Flexible diphenylsulfone versus rigid dibenzothiophene-dioxide as acceptor moieties in donor-acceptor-donor TADF emitters for highly efficient OLEDs

2020

DG acknowledges funding from the ERDF PostDoc project No. 1.1.1.2/VIAA/1/16/177 . This research is/was funded by the European Regional Development Fund according to the supported activity ‘ Research Projects Implemented by World-class Researcher Groups ’ under Measure No. 01.2.2-LMT-K-718 . Ministry of Science and Technology (MOST), Taiwan , Grant No. MOST 106-2923-E-155-002-MY3 . This work was also supported by the Ministry of Education and Science of Ukraine (projects no. 0117U003908 and 0118U003862 ), and by the Olle Engkvist Byggmästare foundation (contract No. 189-0223 ). The quantum-chemical calculations were performed with computational resources provided by the High Performance Comp…

Towards saturation of the electron-capture delayed fission probability: The new isotopes $^{240}Es$ and $^{236}Bk$

2016

Abstract The new neutron-deficient nuclei 240 Es and 236 Bk were synthesised at the gas-filled recoil separator RITU. They were identified by their radioactive decay chains starting from 240 Es produced in the fusion–evaporation reaction 209 Bi( 34 S,3n) 240 Es. Half-lives of 6 ( 2 ) s and 22 − 6 + 13 s were obtained for 240 Es and 236 Bk, respectively. Two groups of α particles with energies E α = 8.19 ( 3 ) MeV and 8.09 ( 3 ) MeV were unambiguously assigned to 240 Es. Electron-capture delayed fission branches with probabilities of 0.16 ( 6 ) and 0.04 ( 2 ) were measured for 240 Es and 236 Bk, respectively. These new data show a continuation of the exponential increase of ECDF probabilitie…

Ionic multiresonant thermally activated delayed fluorescence emitters for light emitting electrochemical cells

2022

Funding: M. K. would like to thank 2214-A International Research Fellowship Programme for Ph.D. students (1059B141900585). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska Curie grant agreement No 838885 (NarrowbandSSL). S.M.S. acknowledges support from the Marie Skłodowska-Curie Individual Fellowship (grant agreement No 838885 NarrowbandSSL). A. K. G. is grateful to the Royal Society for Newton International Fellowship NF171163. L.M acknowledges that the project who gave rise to these results received support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and inno…

Performance Analysis of Basic Turbo-Roundabouts in Urban Context

2012

AbstractA turbo roundabout is a new type of canalized multilane intersection in which the physical separation between lanes helps to prevent side collisions when crossing the roundabout. This paper presents an estimation of capacity, delays and level of service of basic turbo roundabouts in undersaturation conditions, considering both vehicle flow and pedestrian traffic. The traffic performance model was developed by evaluating the capacity for each entry lane. Owing to the geometric features of the intersection, the total entry capacity is obtained by considering different values of the pedestrian impedance factor and degree of saturation at both the right-turn and left-turn lanes.

Estimation of air pollutant emissions in flower roundabouts and in conventional roundabouts

2013

Abstract The road pollutant emissions, above all in urban context, are correlated to many infrastructural parameters and to traffic intensity and typology. The research work on road junction geometry, carried out in European research centres, has recently allowed to design new road intersection types which are of undoubted interest, especially in terms of traffic functionality and safety, like the flower roundabouts (in which right-turn manoeuvres do not conflict with the circulating flow). The main objective of this paper is to propose a model for the estimation the capacity, delay, levels of service and the pollutant emissions into flower roundabouts. A comparative analysis between conven…