Search results for " Descriptors"
showing 10 items of 49 documents
Potential predictability of crop impacting climate variables for East Africa and application to sorghum in the Mt Kenya area
2013
In Southern countries with rural low income populations, the vulnerability of rainfed agriculture to rainfall variability requires effective solutions to mitigate the effects of climatic hazards on crops. Predicting the characteristics of rainy seasons some time before they start should help the establishment of agricultural adaptation strategies to rainfall hazards. This is the objective of the present study, focused on East Africa (Kenya and northern Tanzania), and divided in three parts:- Define and document intra-seasonal descriptors (ISD) that will be considered in the predictability study. A new methodological approach has been developed in order to define the onset date (ORS) and the…
Antiproliferative Activity Predictor: A New Reliable In Silico Tool for Drug Response Prediction against NCI60 Panel.
2022
In vitro antiproliferative assays still represent one of the most important tools in the anticancer drug discovery field, especially to gain insights into the mechanisms of action of anticancer small molecules. The NCI-DTP (National Cancer Institute Developmental Therapeutics Program) undoubtedly represents the most famous project aimed at rapidly testing thousands of compounds against multiple tumor cell lines (NCI60). The large amount of biological data stored in the National Cancer Institute (NCI) database and many other databases has led researchers in the fields of computational biology and medicinal chemistry to develop tools to predict the anticancer properties of new agents in advan…
Automatic Counting of Intra-Cellular Ribonucleo-Protein Aggregates in Saccharomyces cerevisiae Using a Textural Approach.
2019
AbstractIn the context of microbiology, recent studies show the importance of ribonucleo-protein aggregates (RNPs) for the understanding of mechanisms involved in cell responses to specific environmental conditions. The assembly and disassembly of aggregates is a dynamic process, the characterization of the stage of their evolution can be performed by the evaluation of their number. The aim of this study is to propose a method to automatically determine the count of RNPs. We show that the determination of a precise count is an issue by itself and hence, we propose three textural approaches: a classical point of view using Haralick features, a frequency point of view with generalized Fourier…
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Shape and size in phytoplankton ecology: do they matter?
2007
This paper summarises the outcomes of the 14th Workshop of the International Association of Phytoplankton Taxonomy and Ecology (IAP). The authors mostly addressed their contributions on the following topics: morphological and morpho-functional descriptors of phytoplankton, size and shape structure of phytoplankton related to different kinds of environmental variables and the role of morphological and physiological plasticity of phytoplankton in maintaining the (apparently) same populations under different environmental conditions. Case studies from different kinds of aquatic environments (deep and shallow lakes, reservoirs with different age, purpose and trophic state, floodplain wetlands m…
RootsGLOH2: embedding RootSIFT 'square rooting' in sGLOH2
2020
This study introduces an extension of the shifting gradient local orientation histogram doubled (sGLOH2) local image descriptor inspired by RootSIFT ‘square rooting’ as a way to indirectly alter the matching distance used to compare the descriptor vectors. The extended descriptor, named RootsGLOH2, achieved the best results in terms of matching accuracy and robustness among the latest state-of-the-art non-deep descriptors in recent evaluation contests dealing with both planar and non-planar scenes. RootsGLOH2 also achieves a matching accuracy very close to that obtained by the best deep descriptors to date. Beside confirming that ‘square rooting’ has beneficial effects on sGLOH2 as it happe…
A Two-Stage Reconstruction of Microstructures with Arbitrarily Shaped Inclusions
2020
The main goal of our research is to develop an effective method with a wide range of applications for the statistical reconstruction of heterogeneous microstructures with compact inclusions of any shape, such as highly irregular grains. The devised approach uses multi-scale extended entropic descriptors (ED) that quantify the degree of spatial non-uniformity of configurations of finite-sized objects. This technique is an innovative development of previously elaborated entropy methods for statistical reconstruction. Here, we discuss the two-dimensional case, but this method can be generalized into three dimensions. At the first stage, the developed procedure creates a set of black synthetic …
Keypoint descriptor matching with context-based orientation estimation
2014
Abstract This paper presents a matching strategy to improve the discriminative power of histogram-based keypoint descriptors by constraining the range of allowable dominant orientations according to the context of the scene under observation. This can be done when the descriptor uses a circular grid and quantized orientation steps, by computing or providing a global reference orientation based on the feature matches. The proposed matching strategy is compared with the standard approaches used with the SIFT and GLOH descriptors and the recent rotation invariant MROGH and LIOP descriptors. A new evaluation protocol based on an approximated overlap error is presented to provide an effective an…
Diversity in local cultivars of Pisum sativum collected from home gardens in Sweden
2015
Abstract Although one would assume that finding any local cultivars in home gardens in a modern society such as Sweden is unlikely, such cultivars were in fact found. More than 170 seed accessions of vegetables, pulses and other seed-propagated garden crops maintained in home gardens and dating back at least to the 1950s have been assembled following the nationwide ‘Seed Call’. Of these, 32 garden pea accessions were taxonomically characterized and compared with 43 accessions already present in the gene bank. In addition to morphological descriptors, SSR and retrotransposon-based iPBS markers were applied. Based on five SSR markers, potential duplicates could be located within nine pair/gro…
Indización y uso de los Descriptores MeSH en Hospitalización a Domicilio
2017
Objetivo: Analizar la utilización de los Descriptores, como Major Topic, en la indización de los artículos sobre Hospitalización Domiciliaria en la base de datos MEDLINE.Método: Estudio descriptivo transversal de los registros de indización recogidos en la base de datos MEDLINE (vía PubMed) hasta 2016. El término utilizado, como descriptor principal para la búsqueda fue «Home Care Services, Hospital-Based».El método de muestreo fue la aleatorización simple sin reemplazo, tomando como base el número total de referencias obtenidas (tamaño muestral 386).Resultados: Se observaron diferencias significativas en la utilización de los Descriptores asociados a hospitalización a domicilio. La compara…