Search results for " Design"
showing 10 items of 5050 documents
Noninvasive Ventilation in Critically Ill Patients
2015
Since its first application in the late 1980s, noninvasive ventilation (NIV) has been the first-line intervention for certain forms of acute respiratory failure. NIV may be delivered through the patient's mouth, nose, or both using noninvasive intermittent positive pressure ventilation or continuous positive airway pressure. When applied appropriately, NIV may reduce morbidity and mortality and may avert iatrogenic complications and infections associated with invasive mechanical ventilation. This article provides physicians and respiratory therapists with a comprehensive, practical guideline for using NIV in critical care. © 2015 Elsevier Inc.
Nei luoghi del design
2008
Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening
2018
Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim was to discover novel RORγt ligands using both standard molecular docking and negative image-based screening. Interestingly, both of these in silico techniques put forward mostly the same compounds for experimental testing. In total, 11 of the 34 molecules purchased for testing were verified as RORγt inverse agonists, thus making the effective hit rate 32%. The pIC50 values for the compounds varied from 4.9 (11 μ…
Efficient contour-based annotation by iterative deep learning for organ segmentation from volumetric medical images
2022
Abstract Purpose Training deep neural networks usually require a large number of human-annotated data. For organ segmentation from volumetric medical images, human annotation is tedious and inefficient. To save human labour and to accelerate the training process, the strategy of annotation by iterative deep learning recently becomes popular in the research community. However, due to the lack of domain knowledge or efficient human-interaction tools, the current AID methods still suffer from long training time and high annotation burden. Methods We develop a contour-based annotation by iterative deep learning (AID) algorithm which uses boundary representation instead of voxel labels to incorp…
Patrimonio storico e accessibilità dei centri minori del Parco delle Madonie in Sicilia
2022
Il massiccio montuoso appenninico delle Madonie, sito nella costa settentrionale siciliana tra i fiumi Imera e Pollina, accoglie nei suoi 39.679 ettari ben 21 centri storici minori sparsi, custodi di un patrimonio di tradizioni e valori che costituiscono l’identità dei luoghi, ormai affidata esclusivamente alla memoria collettiva di una popolazione sempre più anziana e inattiva. Posizionati tra l’altitudine minima del paese di Alimena di 218m s.l.m. e la massima di Geraci Siculo di 1.077m s.l.m., i piccoli e grandi borghi si dispongono da costa a monte, distanti dai grandi centri di agglomerazione urbana e di servizio. Caratterizzati da un patrimonio edilizio fortemente legato alle tradizio…
STATUS OF STRANGENESS ELECTRO-PRODUCTION AT MAMI
2009
At the Institut für Kernphysik in Mainz, Germany, the microtron MAMI has been upgraded to 1.5 GeV electron beam energy and can now be used to study strange hadronic systems. The magnetic spectrometer KAOS from GSI was dismantled and re-installed in the spectrometer facility operated by the A1 collaboration. The spectrometer's primary purpose is to study strangeness electro-production. Its compact design and its capability to detect negative and positive charged particles simultaneously under forward scattering angles complements the existing spectrometers. In 2008, an important milestone has been reached by the successful measurement of kaon production off a liquid hydrogen target. The ide…
Il web per la cultura. Dalla digital identity alla progettazione dei servizi in rete.
2006
Negli ultimi decenni è in atto una trasformazione nell’ambito dei beni culturali definibile come un processo di apertura dei luoghi della cultura (musei, siti archeologici, biblioteche, etc.) verso l’esterno, determinato dalle istituzioni stesse, con il loro differente modo di intendere la conservazione e di gestire la fruizione del patrimonio storico-artistico e dal sistema dei fruitori, con la loro diversa domanda del prodotto culturale, che si svolge in tempi e modi differenti rispetto al passato. D’altra parte, gli studiosi della cybercultura segnalano che il nostro tempo, con l’incalzante introduzione di nuove tecnologie e strumenti, apparterrebbe in realtà solo agli albori di una rivo…
Designing a Multichannel Map Service Concept
2013
This paper introduces a user-centered design process for developing a multichannel map service. The aim of the service is to provide hikers with interactive maps through several channels. In a multichannel map service, the same spatial information is available through various channels, such as printed maps, Web maps, mobile maps, and other interactive media. When properly networked, the channels share a uniform identity so that the user experiences the different channels as a part of a single map service. The traditional methods of user-centered design, such as design probes, personas, and scenarios, proved useful even in the emerging field of developing multichannel map services. The findi…
Marine reserves : fish life history and ecological traits matter
2010
Copyright by the Ecological Society of America
Learning research in a laboratory classroom : a reflection on complementarity and commensurability among multiple analytical accounts
2022
With the myriad theories generated through research over the years, a continuing challenge for researchers is to navigate the multitude of theories in order to communicate their research, integrate empirical results, and make progress as a field by building upon empirical research. The Social Unit of Learning project was purposefully designed so that researchers from multiple disciplines with different theoretical perspectives could work together to examine the complexity of the mathematics classroom. In this paper, we reflect on the multiple analytical accounts generated from the project, drawing from the notions of complementarity and commensurability. Two parallel analyses, applying the …