Search results for " Direct"
showing 10 items of 943 documents
NUOVE AREE DI RILEVANTE INTERESSE NATURALISTICO NELLA SICILIA CENTRO-OCCIDENTALE: PROPOSTA DI TUTELA
2011
New areas of outstanding natural importance in central-western Sicily: a proposal for their conser- vation. With a view to the expected updating of the Sites of Community Importance (SCI) and the following designation of the Special Areas of Conservation (SAC) by the Italian Ministry according to the Council Directive 92/43/EEC, some areas of outstanding natural importance in central-west- ern Sicily, currently not protected, are identified and described. Fifteen areas of various sizes are located in five different provinces (Trapani, Palermo, Agrigento, Caltanissetta and Enna); here sev- eral habitats of Community interest, including some prioritary ones, and numerous endemic and/or rare s…
The SISV support to the implementation of a national manual for monitoring the Habitats of the 92/43/EEC Directive in Italy.
2016
The 4th National Report ex Art. 17 of the 92/43/EEC Directive in Italy (period 2013-2018) will try to fill a number of gaps still affecting the former versions of the Italian Reports, where territorial data were still missing for large parts of the country and the assessment was mostly based on the use of the expert opinion. Similar inconsistencies also emerged in other European countries (State of nature in the EU, EEA 2015). In order to reach this aim, a nationally shared protocol for monitoring the vegetation-based Annex I Habitats is currently under development. The most prominent issues addressed by the ongoing project are: i) fixing standardized, updated and scientifically grounded me…
Unsolved questions and preferred solution about living will
2018
Abstract Background Ethical problems about end-of-life medicine include a variety of issues approached in different ways by physicians and, more recently, special emphasis to this kind of ethical issues and possible answers has done by Italian National Ethical Committee in the issue named “Deep and continuous palliative sedation in the imminence of Death” (January, 2016). The debate is very critical in Intensive Care Units and Cancer Wards, where health care professionals face-off with terminally-ill patients is an outright routine; the Authors investigated their medical knowledge and ethical perception about patient critical and terminal condition to discuss the most relevant conclusions. …
Prothrombinase-Induced Clotting Time Assay for Determination of the Anticoagulant Effects of Unfractionated and Low-Molecular-Weight Heparins, Fondap…
2008
The prothrombinase-induced clotting time assay (PiCT, Pentapharm, Basel, Switzerland) is a clotting assay sensitive to factor Xa and factor IIa inhibitors. It is based on the addition of factor Xa and snake venom RVV-V (Russell viper venom factor V activator) specifically activating factor V and phospholipids to platelet-poor plasma. Following an incubation time, the mixture is recalcified and the clotting time is determined. An almost linear dose-response and high sensitivity of the assay for unfractionated heparin (UFH), low-molecular-weight heparins (LMWHs), r-hirudin, and argatroban was found. Fondaparinux showed a nonlinear dose-response. By using ex vivo samples, the following Pearson…
A Sequential Quadratic Programming Method for Volatility Estimation in Option Pricing
2006
Our goal is to identify the volatility function in Dupire's equation from given option prices. Following an optimal control approach in a Lagrangian framework, we propose a globalized sequential quadratic programming (SQP) algorithm with a modified Hessian - to ensure that every SQP step is a descent direction - and implement a line search strategy. In each level of the SQP method a linear-quadratic optimal control problem with box constraints is solved by a primal-dual active set strategy. This guarantees L^1 constraints for the volatility, in particular assuring its positivity. The proposed algorithm is founded on a thorough first- and second-order optimality analysis. We prove the existe…
Implications for dark matter direct detection in the presence of LIGO-motivated primordial black holes
2019
We discuss formation of dark matter (DM) mini-halos around primordial black holes (PBHs) and its implication on DM direct detection experiments, including axion searches. Motivated by LIGO observations, we consider $f_{\textrm{DM}} \simeq 0.01$ as the fraction of DM in PBHs with masses $10 M_{\odot} - 70 M_{\odot}$. In this case, we expect the presence of dressed PBHs after Milky Way halo formation with mini-halo masses peaked around $M_{\textrm{halo}} \sim (50-55) M_{\textrm{PBH}}$. We analyze the effect of tidal forces acting on dressed PBHs within the Milky Way galaxy. In the solar neighborhood, the mini-halos are resistant against tidal disruption from the mean-field potential of the ga…
Corporate Networks and business influence in Panama, Costa Rica, and El Salvador.
2021
Objective/Context: This paper explores the relationship between corporate networks and business influence to figure out the conditions of state capture. Methodology: We analyze corporate networks through interlocking directorates in three Central American countries - Panama, Costa Rica, and El Salvador - using network analysis, and we pinpoint the relationship between the structure of the corporate network and two corporate political actions: contributions to presidential campaigns and revolving doors. Conclusions: Results show corporate networks were fragmented in the three Central American countries, except for a well-connected business cluster in Panama. The organization of business elit…
Da Düsseldorf a Lussemburgo e ritorno: “Towards Horizontal Effect For the Free Movement of Goods?”
2014
A seguito di rinvio pregiudiziale deciso da CGUE 12 luglio 2012 C-171/11, Fra.bo/DVGW, che ammette, per la prima volta, l’efficacia orizzontale, e cioè nei rapporti privatistici, del principio della libera circolazione delle merci, già affermata dalla giurisprudenza europea per le altre libertà fondamentali di circolazione (CGUE 12 luglio 2012 C-171/11, Fra.bo/DVGW, in European Review of Contract Law, 2013, 186, con commento di Harm SHEPEL; nonché, H. van HARTEN, T. NAUTA, Towards Horizontal Direct Effect For the Free Movement of Goods. Comment on Fra.Bo., in European Law Review, 2013, 677; SHUIBHNE, The Coherence of EU Free Movement Law. Consitutional Responsibility and the Court of Justic…
Vertical FDI Revisited
2003
This study explores how relative skilled-wage premia affect FDI. Contrary to previous studies based on factor endowment differences, we find strong support for vertical FDI, in the sense that more FDI is conducted in countries where unskilled labor is relatively cheap. In addition, we find that relative skill-premia also affect FDI activities that have previously been associated with horizontal FDI, i.e. local affiliate sales. Consequently, the potential effects of changes in the relative wage costs on international production reallocation within MNEs are large. In fact, if not for the 8% rise in the US skilled wage premium relative to the average host country between 1986- 1994, annual US …
Protein delivery by subviral particles of human cytomegalovirus
2003
Direct protein delivery is an emerging technology in vaccine development and gene therapy. We could previously show that subviral dense bodies (DB) of human cytomegalovirus (HCMV), a beta-herpesvirus, transport viral proteins into target cells by membrane fusion. Thus these non-infectious particles provide a candidate delivery system for the prophylactic and therapeutic application of proteins. Here we provide proof of principle that DB can be modified genetically. A 55 kDa fusion protein consisting of the green fluorescent protein and the neomycin phosphotransferase could be packed in and delivered into cells by recombinant DB in a functional fashion. Furthermore, transfer of protein into …