Search results for " Dominant"

showing 9 items of 139 documents

Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcin…

1992

Cellular differentiation and mRNA levels of genes involved in kidney growth were investigated in normal kidney cells, cyst-lining epithelial cells of polycystic kidney disease, and renal carcinoma cells (RCC). All cells comparatively studied exhibited an antigenic phenotype of proximal tubular cells as shown by the expression of a panel of brush border membrane enzymes and kidney-associated cell surface antigens. The epithelial developmental antigen Exo-1 was expressed in 50% to 80% of cyst-lining epithelia in polycystic kidney tissue and in 20% to 30% of polycystic kidney cells cultured in vitro. Normal kidney cells and RCC were negative under identical culture conditions. The expression o…

medicine.medical_specialtyTGF alphaCellular differentiationAutosomal dominant polycystic kidney diseaseGene ExpressionBiologyKidneyEpitheliumProto-Oncogene Proteins c-mycGrowth factor receptorEpidermal growth factorInternal medicinemedicinePolycystic kidney diseaseHumansRNA MessengerGrowth SubstancesCarcinoma Renal CellCells CulturedKidneyurogenital systemAntibodies MonoclonalTransforming Growth Factor alphamedicine.diseasePolycystic Kidney Autosomal DominantAntigens DifferentiationImmunohistochemistryKidney NeoplasmsErbB ReceptorsEndocrinologymedicine.anatomical_structureGenesNephrologyAntigens SurfaceCancer researchTransforming growth factorAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
researchProduct

Does δ-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?

2009

In this study we clinically and genetically characterize a consanguineous family with a homozygous novel missense mutation in the delta-sarcoglycan gene and a second delta-sarcoglycan mutation that has previously been reported to cause severe autosomal-dominant dilated cardiomyopathy. We identified a novel missense mutation in exon 6 (p.A131P) of the delta-sarcoglycan gene, which in a homozygous state leads to the clinical picture of a limb girdle muscular dystrophy. In four heterozygous carriers for the mutation, aged 3-64 years, a second sequence variant in exon 6 (p.S151A) of the delta-sarcoglycan gene was detected on the other allele. This second missense change had previously been repo…

musculoskeletal diseasesAdultCardiomyopathy DilatedMalemedicine.medical_specialtyAdolescentBiopsyDNA Mutational AnalysisCardiomyopathyMutation MissenseCompound heterozygosityArticleExonConsanguinityElectrocardiographyYoung AdultInternal medicineSarcoglycansGeneticsMedicineMissense mutationHumansMuscular dystrophyChildGenetics (clinical)Genes DominantGeneticsFamily Healthbusiness.industryMusclesMyocardiumDilated cardiomyopathyMiddle Agedmedicine.diseasePedigreeEndocrinologyEchocardiographyChild PreschoolMutation (genetic algorithm)FemalebusinessLimb-girdle muscular dystrophy
researchProduct

Antecedentes estratégicos de la capacidad de innovación empresarial y sus efectos en los resultados

2016

La presente tesis doctoral propone un modelo teórico sobre los antecedentes estratégicos que influyen en la capacidad de innovación de la empresa y su relación con los resultados empresariales. El modelo se construye desde una aproximación integradora de teorías y enfoques que une la teoría de recursos y capacidades y su extensión al enfoque de las capacidades dinámicas y el enfoque basado en el conocimiento, el enfoque al marketing, la teoría del aprendizaje organizacional y la Lógica Dominante del Servicio. Tras una aproximación cualitativa, el modelo se contrastó empíricamente con una muestra representativa de 210 empresas de Valencia y su área metropolitana con representación proporcion…

recursos estratégicosorientación al clienteresultados empresarialescapacidad de innovaciónresultados de clienteslógica dominante del servicioresultados de marketingcolaboración del clienteparticipación del empleadogestión del conocimiento del clienteorientación a la innovaciónproceso de innovacióncapacidades estratégicas
researchProduct

RIFIUTO A CONTRARRE E DIRITTO ANTITRUST UNA COMPARAZIONE TRA GLI ORDINAMENTI ITALIANO, EUROPEO E STATUNITENSE

Il lavoro presentato si prefigge lo scopo, muovendo dagli sviluppi della legislazione nazionale e comunitaria, ed alla luce dell’esperienza nordamericana, di chiarire in quali casi il rifiuto a contrarre costituisca uno strumento diretto ad eliminare la concorrenza o, più ampiamente, a pregiudicare il diritto di contrarre di chi aspiri ad instaurare rapporti commerciali con un’impresa in posizione dominante sul mercato. Gli obiettivi perseguiti sono quelli di ricondurre ad unità il concetto di essential facility nella più ampia tematica del rifiuto di contrarre, o di contrattare, ovvero del refusal to deal or to supply. In un’epoca caratterizzata dalla crescente concentrazione del potere ec…

rifiuto a contrarreconcorrenzaSettore IUS/02 - Diritto Privato Comparatoabuso posizione dominante
researchProduct

Milieux professionnels et FASP médicale : de l’autre côté du miroir

2004

Le but de cette étude, est de mettre en lumière et d’analyser les relations entre les milieux professionnels de la médecine et la fiction à substrat professionnel (FASP). Il est convenu de dire que les medical thrillers, dont les caractéristiques principales en tant que sous-groupe générique de la FASP sont présentées ici, offrent un reflet plutôt fidèle du monde de la médecine. L’auteur montre l’intégration en profondeur du discours et des pratiques de la communauté médicale dans la trame paratextuelle, narrative et linguistique des romans à suspense à dominante médicale. Afin de mieux comprendre les relations entre l’environnement professionnel et l’œuvre de fiction, l’auteur présente les…

romans à suspense à dominante médicaleLinguistics and Languagemedicinemedia_common.quotation_subjectArtmedical thrillerFASP.[SHS.GENRE] Humanities and Social Sciences/Gender studies[SHS.LANGUE] Humanities and Social Sciences/LinguisticsLanguage and Linguisticsprofessionally-based fiction[ SHS.GENRE ] Humanities and Social Sciences/Gender studiesprofessional backgroundFASProman à suspense à dominante médicalemedical thrillers[ SHS.LANGUE ] Humanities and Social Sciences/Linguisticsprofessionally-based fiction.[SHS.LANGUE]Humanities and Social Sciences/Linguistics[SHS.GENRE]Humanities and Social Sciences/Gender studiesmédecineHumanitiesmilieu professionnelmedia_common
researchProduct

Seabream(Sparus aurata)hierarchy among alfa and beta subordinates and dominant interplay affects stress responses and phagocytic activity by peritone…

2013

seabream, subordinates, dominant

seabream subordinates dominant
researchProduct

Utilitarian Use of Social Media Services - A Study on Twitter

2018

This paper applies structuration theory (ST) and service dominant logic (SDL) as lenses to study different uses of information systems (IS). We argue that resources provided by IS may be combined and reproduced by appropriating them for different purposes than the design purposes of the IS. The study provides empirical data and analysis to showcase the use of resources for utilitarian purposes in the context of social media services (SMS). Through an analysis of sponsored tweets on Twitter, we show that users employ implicit and explicit resources for utilitarian outcomes. Our findings imply that users create their own service through appropriation of resources available in the social conte…

service dominant logicTwitter05 social sciencessosiaalinen media050801 communication & media studiesStructuration theoryAdvertising0508 media and communications0502 economics and businessrakenteistumisteoria050211 marketingSocial mediasocial media servicesSociologystrukturaatioteoriatietojärjestelmätService-dominant logicProceedings of the 51st Hawaii International Conference on System Sciences
researchProduct

Skolēna smadzeņu puslodes dominantes un prasmju attīstības ietekme uz mācību procesu matemātikas priekšmetā, tēmās par telpiskiem ķermeņiem, balstoti…

2020

Darba mērķis ir izpētīt smadzeņu puslodes dominantes ietekmi uz skolēna domāšanas un atrisinājuma meklēšanas gaitu uzdevumos par telpiskajiem ķermeņiem un izveidot palīgmateriālus skolēniem ar vājāk attīstītu telpisko domāšanu . Pētījuma gaitā tiek plānots apkopot informāciju par mācību procesa diferencēšanu un smadzeņu puslodes dominantes ietekmi uz mācīšanos , un veikt nelielas grupas izpēti pēc Gardnera testa un novērot tās rīcību, risinot uzdevumus, kas saistās ar telpisko iztēli. Izveidot un aprobēt uz nelielas grupas palīgmateriālus skolēniem ar vājāk attīstītu telpisko domāšanu. Tiek prognozēts, ka skolēniem, ar dominējošo kreiso smadzeņu puslodi, risinot uzdevumus par telpiskiem ķer…

smadzeņu puslodes dominantediferencēšanaPedagoģijamācīšanāstelpiskā domāšana
researchProduct

«Facebook credits» e commercializzazione di beni virtuali per social games: l’abuso di posizione dominante alla prova di un mercato con piattaforma p…

2012

The Social Networks themselves don’t satisfy the minimal requirements needed to make a classical market. They are, in fact, just a background for gratuitous relations between (social) users, within a complex network. It’s nonetheless possible to look a the social networks also as an indispensable virtual infrastructure (a platform) for the functioning of classical markets, collateral to their own core business: the market of virtual gifts to be used within the social network, the market for apps. for social network and so on, wich is to say typical examples of multisided platform markets, whose functioning rests on network effects, network externalities. Within such a framework the Author e…

social network-abuse of dominant positiion-two sided platform marketsSettore IUS/01 - Diritto Privato
researchProduct