Search results for " Dynamic"

Structural Design of Frames Able to Prevent Element Buckling

2012

Two formulations of a special multicriterion optimal design problem devoted to elastic perfectly plastic steel frame structures subjected to different combinations of static and dynamic loads are presented. In particular, two minimum volume design problem formulations are proposed: in the first one the structure is designed so as to be able to elastically behave for the assigned fixed loads, to elastically shakedown for serviceability seismic load conditions and to prevent the instantaneous collapse for suitably chosen combinations of fixed and ultimate seismic loadings; in the second one the structure must also satisfy further appropriate constraints related to element buckling. The action…

A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha

2016

Conceptualizing ecosystem tipping points within a physiological framework

2017

Connecting the nonlinear and often counterintuitive physiological effects of multiple environmental drivers to the emergent impacts on ecosystems is a fundamental challenge. Unfortunately, the disconnect between the way “stressors” (e.g., warming) is considered in organismal (physiological) and ecological (community) contexts continues to hamper progress. Environmental drivers typically elicit biphasic physiological responses, where performance declines at levels above and below some optimum. It is also well understood that species exhibit highly variable response surfaces to these changes so that the optimum level of any environmental driver can vary among interacting species. Thus, specie…

NMR and μ+SR detection of unconventional spin dynamics in Er(trensal) and Dy(trensal) molecular magnets

2019

Walking and Running Require Greater Effort from the Ankle than the Knee Extensor Muscles.

2016

The knee and ankle extensors as human primary antigravity muscle groups are of utmost importance in a wide range of locomotor activities. Yet, we know surprisingly little about how these muscle groups work, and specifically, how close to their maximal capacities they function across different modes and intensity of locomotion. Therefore, to advance our understanding of locomotor constraints, we determined and compared relative operating efforts of the knee and ankle extensors during walking, running, and sprinting.Using an inverse dynamics biomechanical analysis, the muscle forces of the knee and ankle extensors during walking (1.6 m·s), running (4.1 m·s), and sprinting (9.3 m·s) were quant…

Load Distribution in the Lumbar Spine During Modeled Compression Depends on Lordosis.

2021

Excessive or incorrect loading of lumbar spinal structures is commonly assumed as one of the factors to accelerate degenerative processes, which may lead to lower back pain. Accordingly, the mechanics of the spine under medical conditions, such as scoliosis or spondylolisthesis, is well-investigated. Treatments via both conventional therapy and surgical methods alike aim at restoring a “healthy” (or at least pain-free) load distribution. Yet, surprisingly little is known about the inter-subject variability of load bearings within a “healthy” lumbar spine. Hence, we utilized computer tomography data from 28 trauma-room patients, whose lumbar spines showed no visible sign of degeneration, to …

Comparison between the directly measured achilles tendon force and the tendon force calculated from the ankle joint moment during vertical jumps.

1988

Summary The purpose of this study was to compare the relationship between the achilles tendon force and the tendon force estimated from the ankle joint moment (EATF) during vertical jump. A healthy male subject performed the following jumps on the force platform: (a) maximal vertical jump from a squat position without counter-movement; (b) maximal vertical jump from an erect standing position with a preliminary counter-movement; (c) repetitive submaximal hopping on the spot with preferred frequency. The achilles tendon force was measured directly with an implanted tendon transducer in all jumping conditions. In addition the joint moment obtained from the film and ground reaction force was u…

Ritz Solution for Transient Analysis of Variable-Stiffness Shell Structures

2020

The dynamic response of thin-walled structures is driven by mass and stiffness distribution. As such, variable-stiffness (VS) composites offer opportunities to tune structural dynamic responses. To this extent, efficient analysis tools become increasingly important for structural analysis and design purposes. In this work, an efficient and versatile Ritz method for free vibrations and linear transient analysis of VS doubly curved shell structures is presented. VS shell structures are modeled as an assembly of shell-like domains. The shell kinematics is based on the first-order shear deformation theory, and no further assumption is made on the shallowness or on the thinness of the structure.…

Multiphoton Absorption of Myoglobin Nitric-Oxide complex: Relaxation by D-NEMD of a Stationary State

2012

ABSTRACT: The photodissociation and geminate recombination of nitric oxide in myoglobin, under continuous illumination, is modeled computationally. The relaxation of the photon energy into the protein matrix is also considered in a single simulation scheme that mimics a complete experimental setup. The dynamic approach to non-equilibrium molecular dynamics is used, starting from a steady state, to compute its relaxation to equilibrium. Simulations are conducted for the native form of sperm whale myoglobin and for two other mutants, V68W and L29F, illustrating a fair diversity of spatial and temporal geminate recombination processes. Energy flow to the heme and immediate protein environment …

Proteins in Amorphous Saccharides: Structural and Dynamical Insights on Bioprotection

2011

We report on experimental and simulative insights on saccharide-based bioprotection, obtained through the study of proteins embedded in amorphous saccharide matrices. The data presented come from a complementary set of techniques (FTIR, MD simulations and SAXS), which provides a description of the bioprotection mechanism from the atomistic to the macroscopic level. The results concur to draw a picture in which bioprotection by saccharides can be explained in terms of a tight anchorage of the protein surface to a stiff matrix, via extended hydrogen-bond networks, whose properties are defined by all its components, and are strongly dependent on the water content. In particular, they show how …