Search results for " E.P.E."
showing 10 items of 5612 documents
Iron Induces Proliferation and Morphogenesis in Primmorphs from the Marine SpongeSuberites domuncula
2002
Dissociated cells from marine demosponges retain their proliferation capacity if they are allowed to form special aggregates, the primmorphs. On the basis of incorporation studies and septin gene expression, we show that Fe3+ ions are required for the proliferation of cells in primmorphs from Suberites domuncula. In parallel, Fe3+ induced the expression of ferritin and strongly stimulated the synthesis of spicules. This result is supported by the finding that the enzymatic activity of silicatein, converting organosilicon to silicic acid, depends on Fe3+. Moreover, the expression of a scavenger receptor molecule, possibly involved in the morphology of spicules, depends on the presence of Fe3…
The fnr Gene of Bacillus licheniformis and the Cysteine Ligands of the C-Terminal FeS Cluster
1998
Many of the O2-responsive gene regulators of bacteria are members of the fumarate nitrate reductase-cyclic AMP receptor protein family of transcriptional regulators (12, 13, 15, 17) with predicted structures similar to those of the cyclic AMP receptor protein (11). The Fnr (stands for fumarate nitrate reductase regulator) protein from Escherichia coli (FnrEc) controls the expression of a variety of genes, mainly of anaerobic respiration and metabolism (5, 13). It contains a N-terminal cluster of three essential cysteine residues which are supposed to bind together with Cys122 a [4Fe 4S]2+ cluster which is required for O2 sensing (4, 7, 8, 10, 16). A wide variety of gram-negative bacteria co…
Comparative study of initial stages of copper immersion deposition on bulk and porous silicon
2013
Initial stages of Cu immersion deposition in the presence of hydrofluoric acid on bulk and porous silicon were studied. Cu was found to deposit both on bulk and porous silicon as a layer of nanoparticles which grew according to the Volmer-Weber mechanism. It was revealed that at the initial stages of immersion deposition, Cu nanoparticles consisted of crystals with a maximum size of 10 nm and inherited the orientation of the original silicon substrate. Deposited Cu nanoparticles were found to be partially oxidized to Cu2O while CuO was not detected for all samples. In contrast to porous silicon, the crystal orientation of the original silicon substrate significantly affected the sizes, dens…
Defective copper transport in the copt5 mutant affects cadmium tolerance.
2014
Cadmium toxicity interferes with essential metal homeostasis, which is a problem for both plant nutrition and the consumption of healthy food by humans. Copper uptake is performed by the members of the Arabidopsis high affinity copper transporter (COPT) family. One of the members, COPT5, is involved in copper recycling from the vacuole toward the cytosolic compartment. We show herein that copt5 mutants are more sensitive to cadmium stress than wild-type plants, as indicated by reduced growth. Exacerbated cadmium toxicity in copt5 mutants is due specifically to altered copper traffic through the COPT5 transporter. Three different processes which have been shown to affect cadmium tolerance ar…
La insolvencia en el ámbito de las relaciones laborales: causas, efectos y propuestas
2015
La presente tesis doctoral viene a recoger el resultado de un profundo trabajo de investigación sobre la materia objeto de estudio, a saber, la insolvencia empresarial en el ámbito de las relaciones laborales, con especial concreción en el período de abarca desde el inicio de la denominada crisis económica (año 2007) hasta el presente, como una de las problemáticas a las que el derecho ha de hacer frente en el ámbito laboral. El texto viene a reflejar la relevancia de una urgente búsqueda de instrumentos jurídicos que permitan de un lado, resolver la problemática de la insolvencia empresarial desde su raíz, y de otro, reducir el impacto de sus efectos, especialmente sobre aquellos que recae…
Antecedents and Outcomes of Absorptive Capacity : Three Studies in the Spanish Manufacturing Sector
2013
En los últimos años, las investigaciones en dirección estratégica han señalado al conocimiento como uno de los recursos claves que permiten la generación de ventajas competitivas. No obstante, para la creación y mantenimiento de dichas ventajas es necesario el desarrollo de capacidades que permitan la transferencia y uso eficiente de dicho conocimiento, incluso en condiciones marcadas por la agitación y el dinamismo del entorno. En este marco, la capacidad de absorción ha sido destacada como una de las capacidades esenciales que proporciona a las organizaciones la habilidad de asimilar, transformar y explotar con éxito el conocimiento externo. No obstante, a pesar de las constantes contribu…
Alcohol Abuse Mediates the Association between Baseline T/C Ratio and Anger Expression in Intimate Partner Violence Perpetrators.
2015
The imbalance between testosterone (T) and cortisol (C) levels has been proposed as a possible marker of risk for intimate partner violence (IPV). Moreover, it could be related to a high probability of adopting risky behaviors such as alcohol abuse which, in turn, promotes the onset of IPV. This study tested the potential mediating effect of alcohol consumption on the relationship between baseline T/C ratio and anger expression in IPV perpetrators and non-violent controls. Alcohol consumption was higher in the former than controls. A high baseline T/C ratio was only associated with high anger expression in IPV perpetrators, and this association was mediated by high alcohol consumption. Thus…
Introducción a la investigación cualitativa en enseñanza
2014
Breve introducción a la investigación en la enseñanza. La yuxtaposición de dos paradigmas: cualitativo y positivista. La posibilidad de centrar la investigación en un problema en el contexto del aula. In Educational research, this text explore some of the assumptions related to the characteristics and notions of qualitative paradigm. Identify and propose models of classroom research.
Institutos de investigación sanitaria e investigación traslacional: análisis exploratorio del papel facilitador de la gestión de la calidad
2016
El fenómeno de la investigación traslacional ha irrumpido en el mundo de la biomedicina en la última década como una forma de investigación biomédica que persigue la incorporación de los avances científicos en la práctica médica. Puesto que el tránsito del conocimiento desde el laboratorio hasta el paciente está sometido a un gran número de obstáculos, el proceso de traslación resulta sumamente ineficiente. De hecho, distintos estudios sugieren que menos de una décima parte de los avances biomédicos más prometedores alcanzan finalmente la práctica clínica. Por ello y por su potencial impacto en la salud de la población, el término se ha incorporado con fuerza en el discurso político de las …
Cell and molecular response to IORT treatment
2014
Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selectio…