Search results for " E.P.E."
showing 10 items of 5612 documents
IL-2 Expression in Activated Human Memory FOXP3(+) Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors …
2012
The human CD4(+)FOXP3(+) T cell population is heterogeneous and consists of various subpopulations which remain poorly defined. Anergy and suppression are two main functional characteristics of FOXP3(+)Treg cells. We used the anergic behavior of FOXP3(+)Treg cells for a better discrimination and characterization of such subpopulations. We compared IL-2-expressing with IL-2-non-expressing cells within the memory FOXP3(+) T cell population. In contrast to IL-2-non-expressing FOXP3(+) cells, IL-2-expressing FOXP3(+) cells exhibit intermediate characteristics of Treg and Th cells concerning the Treg cell markers CD25, GITR, and Helios. Besides lower levels of FOXP3, they also have higher levels…
Libertad de expresión y el caso del lenguaje del odio. Una aproximación desde la perspectiva norteamericana y la perspectiva alemana
2010
Resumen Este artículo analiza las concepciones sobre la libertad de expresión en el caso del lenguaje del odio, centrándose en algunos aspectos de la perspectiva norteamericana y en algunos aspectos de la perspectiva alemana. El primer modelo está basado en la libertad negativa y se corresponde con la visión del mercado de las ideas que ha elaborado la jurisprudencia de la Corte Suprema norteamericana. Este Tribunal ha otorgado una papel prioritario a la libertad de expresión, que debería limitarse sólo en casos de un peligro claro y presente o amenaza de desordenes públicos. El segundo modelo, centrado en la libertad positiva, otorga un papel prioritario a la dignidad humana frente a la l…
Jocs de llenguatge en escena
2015
Resum: Aquest article gira a l’entorn de la presència, en l’escena catalana, del contrast de registres lingüístics en unes versions que van més enllà del marc estricte de la normativa oficial. A aquest efecte, s’utilitzen com a objectes d’anàlisi les versions de dues peces teatrals dutes a terme en contextos històrics i sociopolítics molt diferents —la de Joan Oliver de Pygmalion, de G.B. Shaw (1957), i la de Joan Sellent de Translations, de Brian Friel (2014)— i se’n ressalten les afinitats i diferències, tant pel que fa a la tria dels materials lingüístics com als objectius dramatúrgics i ideològics.Tant en una versió com en l’altra, la transgressió freqüent de les normes de la Secció Fil…
Especialització i reinterpretació en les expressions idiomàtiques
1995
It can be shown that the semantic specialization of idioms is a matter of degree, and that semantic interpretation is not just a question of bottom-up compositionality or literal-to-figurative transfer: the reinterpretation processes that can be observed in idioms point to the existence of top-down and figurative-to-literal interpretations.
Internal Communication System Analysis in a Small Company
2017
[EN] The aim of this paper is to analyze the internal communication system in a small company. We used structured interviews in all hierarchical levels to compare the perceptive differences and the way of using the communication tools. A total of five one-hour interview sessions were made to evaluate the involved variables in every communicative tool appointed byor-ganization members. The results showed some contradictions between the respondentsand a low horizontal and descending communication caused by the limited use of these commu-nication tools. Finally, suggestions for improvements to prevent problems and enhance their positive effects were informed.
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
2015
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress resulting in cell death in white matter after hypoxic or ischemic insults of premature infants and destruction of OPC in some types of Multiple Sclerosis lesions. Here we show that the NG2 proteoglycan binds OMI/HtrA2, a mitochondrial serine protease which is released from damaged mitochondria into the cytosol in response to stress. In the cytosol, OMI/HtrA2 initiates apoptosis by proteolytic degradation of anti-apoptotic factors. OPC in which NG…
EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.
2015
KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in cell lines with different KRAS mutations. Cells harboring a single KRASG13D allele showed the most tumorigenic profile, with constitutive activation of the downstream pathway, rendering them EGF-unresponsive. Conversely, KRASA146T cells showed a full EGF-response in terms of signal transduction pathways, cell proliferation, migration or adhesion. Moreover, the global acetylome of CRC cells was al…
Empresas y Derechos Humanos. O cómo llevar la pedagogía crítica al aula de español como lengua extranjera
2013
Este artículo expone un estudio de caso llevado a cabo con estudiantes universitarios del Collège Européen Franco Allemand de Sciences Po París en Nancy basado en la pedagogía crítica. El objetivo principal fue hacer tomar conciencia a los participantes (futuros miembros de empresas y organizaciones europeas e internacionales) del irrespeto de Derechos Humanos por parte de algunas corporaciones transnacionales en América Latina. Mediante este estudio también se buscó generar reflexión en los estudiantes y llevarlos a evaluar problemas precisos, tratar de encontrar soluciones y actuar a corto y mediano plazo para aportar una solución. Las conclusiones arrojadas revelan que se puede aprender …
Parasite presence induces gene expression changes in an ant host related to immunity and longevity
2021
Most species are either parasites or exploited by parasites, making parasite&ndash
The distributions of protein coding genes within chromatin domains in relation to human disease.
2019
Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…