Search results for " EVALUATION"

La valutazione del Consiglio di Amministrazione in contesti ad elevata concentrazione proprietaria: mero conformismo o reale strumento di valutazione?

2018

Board evaluation is a best practice required on voluntary bases by Code of conduct. Despite its voluntary nature, companies very likely adopted this recommendation because the failure to adopt could have a negatively impact on company legitimation and reputation. Moreover, the implementation modalities of BE, however, could be negatively influenced by the specific companies’ ownership structure. The ownership concentration and the search for corporate legitimacy can lead at two possible situations: the BE have only formally adoption or BE have adoption in form and substance. What prevails in the context of ownership concentrated firms? Companies adopt the recommendation to comply with other…

Managing Human Factors to Reduce Organisational Risk in Industry

2018

[EN] Human factors are intrinsically involved at virtually any level of most industrial/business activities, and may be responsible for several accidents and incidents, if not correctly identified and managed. Focusing on the significance of human behaviour in industry, this article proposes a multi-criteria decision-making (MCDM)-based approach to support organizational risk assessment in industrial environments. The decision-making trial and evaluation laboratory (DEMATEL) method is proposed as a mathematical framework to evaluate mutual relationships within a set of human factors involved in industrial processes, with the aim of highlighting priorities of intervention. A case study relat…

A Neuroprotective Function for the Hematopoietic Protein Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)

2007

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine responsible for the proliferation, differentiation, and maturation of cells of the myeloid lineage, which was cloned more than 20 years ago. Here we uncovered a novel function of GM-CSF in the central nervous system (CNS). We identified the GM-CSF α-receptor as an upregulated gene in a screen for ischemia-induced genes in the cortex. This receptor is broadly expressed on neurons throughout the brain together with its ligand and induced by ischemic insults. In primary cortical neurons and human neuroblastoma cells, GM-CSF counteracts programmed cell death and induces BCL-2 and BCL-Xl expression in a dose- a…

Hirsutane-Type Sesquiterpenes with Uncommon Modifications from Three Basidiomycetes

2010

From three basidiomycetes, Xeromphalina sp., Stereum sp., and Pleurocybella porrigens, six triquinane sesquiterpenes with unprecendented modifications and a rearranged sesquiterpene related to coriolin C have been isolated. Their isolation, structure elucidation, and biological evaluation are described.

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

2014

International audience; : Transverse and longitudinal relaxation times (T1ρ and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are isolated from neighboring magnetic nuclei. The resulting functionalized ligands have longitudinal relaxation times T1 ((1) H) that are sufficiently long to allow the powerf…

Ultrasonic nondestructive testing of building materials for the diagnosis and characterization of the decay due to salts crystallization

2020

The possibility to use ultrasonic nondestructive testing for the diagnosis and characterization of decay in building materials due to salts crystallization is here investigated. Salts crystallization is one of the main sources of decay for stone materials, especially for cultural heritage items underwater or exposed to water, and its early detection as well as a continuous monitoring is highly desirable. Currently, this often requires the use of destructive methods and the sampling of the items under inspection. This work shows promises to the successful use for this purpose of ultrasonic nondestructive testing.

Topical treatment with a two-component gel releasing nitric oxide cures C57BL/6 mice from cutaneous leishmaniasis caused by Leishmania major.

2016

Validation of Teacher Self-efficacy (QAI) Questionnaire

2021

Negli ultimi anni numerose ricerche nazionali e internazionali hanno messo in evidenza l’importanza della Teacher Self Efficacy. Nonostante nel panorama nazionale esistano già alcuni strumenti che indagano tale costrutto, si notano sovrapposizioni e divergenze nei diversi fattori presi in considerazione, quali ad esempio la percezione di autoefficacia relativa alla possibilità di agire sull’engagement degli studenti e sulla colla- borazione con la famiglia e altre figure professionali. Pertanto l’obiettivo del presente contributo consiste nella costruzione e validazione di un nuovo strumento che tenga conto di entrambi quest’ultimi aspetti. Lo strumento, costituito da 25 item, è stato so…

Full-scale validation of bio-recycled asphalt mixtures for road pavements

2019

Abstract Recycling of asphalt has become a well-established practice in many countries, however the road pavement industry remains a bulk consumer of extracted raw materials. Novel solutions that find root in circular economy concepts and life-cycle approaches are needed in order to enable optimisation of infrastructure resource efficiency, starting from the design stage and spanning the whole value chain in the construction sector. Itis within this framework that the present study presents a full-scale validation of asphalt mixtures specifically designed to ensure durability of flexible road pavements and at the same time enabling the reuse of reclaimed asphalt pavement (RAP) through the i…

Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pande…

2020

Background Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge. Methods A literature search was performed for the screening of natural and derived bio-active compounds which showed po…