Search results for " EXPRESSION"
showing 10 items of 4731 documents
Is It Really That Funny? Laughter, Emotional Contagion, and Heuristic Processing During Shared Media Use
2017
ABSTRACTWhen people use humorous media content, their behavior and assessments of the content may depend on the emotional expressions (e.g., laughter) of those around them. In a laboratory experiment in which 80 participants watched a movie clip with a confederate who either laughed or remained silent, we identified two parallel processes. The confederate’s laughter induced behavioral responses in our participants (laughing or smiling). Through those responses, a corresponding appraisal of the media content was generated: The content was rated funnier in comparison to situations in which the confederate did not laugh. This effect corresponds to emotional contagion processes and was especial…
The communication of melancholy, grief, and fear in dance with and without music
2020
Professional dancers were video recorded dancing with the intention of expressing melancholy, grief, or fear. We used these recordings as stimuli in two studies designed to investigate the perception and sociality of melancholy, grief, and fear expressions during unimodal (dancing in silence) and multimodal (dancing to music) conditions. In Study 1, viewers rated their perceptions of social connection among the dancers in these videos. In Study 2, the same videos were coded for the amount of time that dancers spent in physical contact. Results revealed that dancers expressing grief and fear exhibited more social interactions than dancers expressing melancholy. Combined with the findings of …
UBFC-Phys: A Multimodal Database For Psychophysiological Studies of Social Stress
2021
As humans, we experience social stress in countless everyday-life situations. Giving a speech in front of an audience, passing a job interview, and similar experiences all lead us to go through stress states that impact both our psychological and physiological states. Therefore, studying the link between stress and physiological responses had become a critical societal issue, and recently, research in this field has grown in popularity. However, publicly available datasets have limitations. In this article, we propose a new dataset, UBFC-Phys, collected with and without contact from participants living social stress situations. A wristband was used to measure contact blood volume pulse (BVP…
Chemosensory Receptors in the Larval Maxilla of Papilio hospiton
2022
Among the butterflies of the genus Papilio (Lepidoptera: Papilionidae), Papilio hospiton (Géné) has a geographical distribution limited to the Mediterranean islands of Sardinia (Italy) and Corsica (France). This is mainly due to the host range that includes only a few plant species of Apiaceae and Rutaceae growing on these islands. In a previous electrophysiological investigation conducted on the maxillary gustatory system of larvae of P. hospiton and its closely phylogenetically related species Papilio machaon, a significantly higher spike activity was shown for the gustatory neurons of lateral and medial styloconic sensilla in P. hospiton when bitter compounds were tested. This effect was…
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
2014
The blind mole rat (BMR), Spalax galili, is an excellent model for studying mammalian adaptation to life underground and medical applications. The BMR spends its entire life underground, protecting itself from predators and climatic fluctuations while challenging it with multiple stressors such as darkness, hypoxia, hypercapnia, energetics and high pathonecity. Here we sequence and analyse the BMR genome and transcriptome, highlighting the possible genomic adaptive responses to the underground stressors. Our results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to hypoxia tolerance, degene…
Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax.
2010
The subterranean mole rat Spalax is an excellent model for studying adaptation of a mammal toward chronic environmental hypoxia. Neuroglobin (Ngb) and cytoglobin (Cygb) are O 2 -binding respiratory proteins and thus candidates for being involved in molecular hypoxia adaptations of Spalax . Ngb is expressed primarily in vertebrate nerves, whereas Cygb is found in extracellular matrix-producing cells and in some neurons. The physiological functions of both proteins are not fully understood but discussed with regard to O 2 supply, the detoxification of reactive oxygen or nitrogen species, and apoptosis protection. Spalax Ngb and Cygb coding sequences are strongly conserved. However, mRNA and …
Where Does Nε-Trimethyllysine for the Carnitine Biosynthesis in Mammals Come from?
2014
N(ε)-trimethyllysine (TML) is a non-protein amino acid which takes part in the biosynthesis of carnitine. In mammals, the breakdown of endogenous proteins containing TML residues is recognized as starting point for the carnitine biosynthesis. Here, we document that one of the main sources of TML could be the vegetables which represent an important part of daily alimentation for most mammals. A HPLC-ESI-MS/MS method, which we previously developed for the analysis of N(G)-methylarginines, was utilized to quantitate TML in numerous vegetables. We report that TML, believed to be rather rare in plants as free amino acid, is, instead, ubiquitous in them and at not negligible levels. The occurrenc…
Oxacyclododecindione, a Novel Inhibitor of IL-4 Signaling from Exserohilum rostratum
2008
In a screening program for new metabolites from fungi inhibiting the IL-4 mediated signal transduction, a novel chlorinated macrocyclic lactone, designated as oxacyclododecindione, was isolated from fermentations of the imperfect fungus Exserohilum rostratum. The structure was determined by a combination of spectroscopic techniques. Oxacyclododecindione inhibits the IL-4 induced expression of the reporter gene secreted alkaline phosphatase (SEAP) in transiently transfected HepG2 cells with IC50 values of 20-25 ng/ml (54-67.5 nM). Studies on the mode of action of the compound revealed that the inhibition of the IL-4 dependent signaling pathway is caused by blocking the binding of the activat…
Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa
2019
Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-components systems, that promote addition of 4-amino-4-deoxy-L-arabinose to the lipopolysaccharide (LPS) through upregulation of operon arnBCADTEF-ugd (arn) expression. Here, we demonstrate that mutations occurring in different domains of histidine kinase PmrB or in response regulator PmrA result in coresistance to aminoglycosides and colistin. All seventeen clinical strains tested exhibiting such a cross-resistance phenotype were found to be pmrAB mutants. As shown by gene deletion experiments, the decreased susceptibility of the mutants to aminoglycosides was independent from operon arn but r…