Search results for " EXTENSION"

showing 10 items of 272 documents

Towards Axiomatic Basis of Inductive Inference

2001

The language for the formulation of the interesting statements is, of course, most important. We use first order predicate logic. Our main achievement in this paper is an axiom system which we believe to be more powerful than any other natural general purpose discovery axiom system. We prove soundness of this axiom system in this paper. Additionally we prove that if we remove some of the requirements used in our axiom system, the system becomes not sound. We characterize the complexity of the quantifier prefix which guaranties provability of a true formula via our system. We prove also that if a true formula contains only monadic predicates, our axiom system is capable to prove this formula…

SoundnessDiscrete mathematicsPredicate logicSMorse–Kelley set theoryComputer scienceNon-well-founded set theoryZermelo–Fraenkel set theoryConstructive set theoryInductive reasoningAxiom schemaUrelementScott's trickMonad (functional programming)First-order logicAxiom of extensionalityMathematics::LogicTheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGESTheoryofComputation_LOGICSANDMEANINGSOFPROGRAMSCalculusAxiom of projective determinacyAxiom of choiceKripke–Platek set theoryAction axiomAxiom
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Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.

2020

Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…

TelomeraseProtein Folding:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::DNA-Binding Proteins::Rad52 DNA Repair and Recombination Protein [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins [Medical Subject Headings]Gene ExpressionYeast and Fungal ModelsArtificial Gene Amplification and ExtensionQH426-470BiochemistryPolymerase Chain ReactionChromosome conformation captureHistonesCromatina0302 clinical medicineSirtuin 2Macromolecular Structure AnalysisSilent Information Regulator Proteins Saccharomyces cerevisiaeCellular Senescence:Organisms::Eukaryota::Fungi::Yeasts::Saccharomyces::Saccharomyces cerevisiae [Medical Subject Headings]0303 health sciencesChromosome BiologyEukaryota:Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication [Medical Subject Headings]TelomereSubtelomere:Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Telomere [Medical Subject Headings]Chromatin3. Good healthChromatinCell biologyNucleic acidsTelomeres:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Telomere Homeostasis [Medical Subject Headings]Experimental Organism SystemsDaño del ADNEpigeneticsResearch ArticleSenescenceDNA Replication:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases::Histone Deacetylases [Medical Subject Headings]Chromosome Structure and FunctionProtein StructureSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeBiologyResearch and Analysis MethodsHistone DeacetylasesChromosomes03 medical and health sciencesSaccharomycesModel Organisms:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Intracellular Signaling Peptides and Proteins::Sirtuins::Sirtuin 2 [Medical Subject Headings]:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins::Silent Information Regulator Proteins Saccharomyces cerevisiae [Medical Subject Headings]DNA-binding proteinsGenetics:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Recombinases::Rec A Recombinases::Rad51 Recombinase [Medical Subject Headings]Molecular Biology TechniquesMolecular Biology030304 developmental biologyCromosomasSenescencia celularOrganismsFungiBiology and Life SciencesProteinsTelomere HomeostasisCell BiologyDNAMethyltransferasesG2-M DNA damage checkpointProteína recombinante y reparadora de ADN Rad52YeastTelomereRad52 DNA Repair and Recombination ProteinRepressor ProteinsAnimal Studies:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Transcription Factors::Repressor Proteins [Medical Subject Headings]DNA damageRad51 RecombinaseHomologous recombination030217 neurology & neurosurgeryTelómeroDNA DamagePLoS Genetics
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: A systematic review and meta-analysis of its prognostic significance

2016

The aim of the study was to investigate the prognostic role of extranodal extension (ENE) of lymph node metastasis in adenocarcinoma of the pancreas (PDAC) and papilla [cancer of the papilla of Vater (CPV)]. A PubMed and SCOPUS search from database inception until 5 January 2015 without language restrictions was conducted. Eligible were prospective studies reporting data on prognostic parameters in individuals with PDAC and/or CPV, comparing participants with the presence of ENE (ENE +) with those with intranodal extension (ENE). Data were summarized using risk ratios for number of deaths/recurrences and hazard ratios for time-dependent risk related to ENE+, adjusted for potential confounde…

Time FactorsPapillaPapillary carcinomaGastroenterologyextranodal extension pancreatic adenocarcinoma papilla papillary carcinoma prognosislymph node metastasis adenocarcinoma of the pancreas (PDAC) papilla [cancer of the papilla of Vater (CPV)] extranodal extension (ENE)0302 clinical medicineRisk FactorsOdds RatioProspective cohort studylymph node metastasisHazard ratioAmpulla of VaterGastroenterologyPrognosisextranodal extension (ENE)medicine.anatomical_structureTreatment Outcome030220 oncology & carcinogenesisLymphatic Metastasisadenocarcinoma of the pancreas (PDAC)Disease ProgressionAdenocarcinoma030211 gastroenterology & hepatologymedicine.medical_specialtyAmpulla of VaterCommon Bile Duct NeoplasmsAdenocarcinomapapilla [cancer of the papilla of Vater (CPV)]Disease-Free Survival03 medical and health sciencesExtranodal extension; Pancreatic adenocarcinoma; Papilla; Papillary carcinoma; Prognosis; Gastroenterology; HepatologyPredictive Value of TestsInternal medicineExtranodal extensionmedicineHumansHepatologybusiness.industryOdds ratiomedicine.diseaseConfidence intervalSurgeryMajor duodenal papillaPancreatic NeoplasmsRelative riskLymph NodesNeoplasm Recurrence LocalbusinessPancreatic adenocarcinoma
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Modeling the effect of ethanol vapor on the germination time of Penicillium chrysogenum.

2005

The influence of ethanol vapor on germination of Penicillium chrysogenum was determined on yeast nitrogen base plus glucose agar medium at 25 degrees C. Ethanol vapors were generated by 0 to 6% (wt/wt) ethanol solutions at the bottom of hermetically closed petri dishes. The logistic equation was used to describe the data as the percentage of germination versus time and to estimate the germination time. The effect of ethanol concentration on germination time was described by a new reparameterized equation, resulting in an estimated limiting ethanol concentration of 4.3%. Up to 3% ethanol, all spores germinated, and the germination time increased with increasing ethanol concentration. At 3.5 …

Time FactorsWater activityconidial germinationphbreadGerm tubePenicillium chrysogenumshelf-life extensionMicrobiologyModels BiologicalLevensmiddelenmicrobiologieAgar platechemistry.chemical_compoundFood Preservationwater activityBotanyFood scienceVLAGEthanolbiologyDose-Response Relationship DrugEthanolspoilagetemperatureSpores FungalPenicillium chrysogenumbiology.organism_classificationYeastSporeKineticsLogistic Modelschemistryclostridium-botulinumGerminationFood Microbiologygrowth-rateFood ScienceJournal of food protection
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Extension theory and the calculus of butterflies

2016

Abstract This paper provides a unified treatment of two distinct viewpoints concerning the classification of group extensions: the first uses weak monoidal functors, the second classifies extensions by means of suitable H 2 -actions. We develop our theory formally, by making explicit a connection between (non-abelian) G-torsors and fibrations. Then we apply our general framework to the classification of extensions in a semi-abelian context, by means of butterflies [1] between internal crossed modules. As a main result, we get an internal version of Dedecker's theorem on the classification of extensions of a group by a crossed module. In the semi-abelian context, Bourn's intrinsic Schreier–M…

TorsorCrossed moduleContext (language use)01 natural sciencesCohomologyCohomology; Extension; Fibrations; Obstruction theory; Schreier-mac lane theorem; TorsorsExtensionMathematics::Category Theory0103 physical sciences0101 mathematicsConnection (algebraic framework)MathematicsAlgebra and Number TheoryFunctorGroup (mathematics)010102 general mathematicsTorsorsExtension (predicate logic)Obstruction theorySchreier-mac lane theoremCohomologyFibrationsAlgebraSettore MAT/02 - AlgebraSchreier–Mac Lane theoremSettore MAT/03 - Geometria010307 mathematical physicsObstruction theory
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Bone mineral density and physical activity in 50–60-year-old women

1991

Abstract The bone mineral density (BMD) of the calcaneus was measured utilizing a single energy photon absorption method in 108 women, aged 50–60 years. The women who participated in vigorous exercise two or more times a week or whose total physical activity amounted to 4 h a week had significantly higher BMD values than those who exercised less than two times a week or did less than 4 h physical activity a week. The physically active women also showed higher values for leg extension force and maximal oxygen uptake. BMD and leg extension force were positively correlated, whereas correlations between BMD and body mass, and the width of the calcaneus were negative. When other life-style varia…

Total physical activitymedicine.medical_specialtyAlcohol DrinkingOsteoporosisPhysical activityPhysiologyPhysical Therapy Sports Therapy and RehabilitationPhysical exerciseBiochemistryBone and BonesAbsorptiometry PhotonOxygen ConsumptionEndocrinologyBone DensityHumansMedicineOrthopedics and Sports MedicineExerciseFinlandBone mineralbusiness.industrySignificant differenceBody WeightSmokingVO2 maxMiddle Agedmusculoskeletal systemmedicine.diseaseSkeleton (computer programming)Body HeightMiddle ageBiomechanical PhenomenaSurgeryCalcaneusSkinfold ThicknessOsteoporosisLeg extensionFemaleSurgeryCalcaneusbusinessBone and Mineral
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The Value of Brand Equity

2013

Abstract This paper aims to be a brief presentation of brand equity as a provider of strategic advantages for companies that own brands. Successful management of a brand must be focused on values capitalization so that these attributes could represent a natural extension of general perception. The stated goal of any brand manager is to strengthen the brand values so that they may be easily recognizable and identifiable to the public.

Value (ethics)business.industryBrand awarenessbest brandsGeneral EngineeringEnergy Engineering and Power TechnologyAdvertisingBrand valuationbrand equityBrand managementCorporate brandingBrand extensionComputerApplications_GENERALbrandBrand equityMarketingbusinessbrand valuationComputingMilieux_MISCELLANEOUSCapitalizationperformance indicators.Procedia Economics and Finance
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Highly transitive actions of groups acting on trees

2015

We show that a group acting on a non-trivial tree with finite edge stabilizers and icc vertex stabilizers admits a faithful and highly transitive action on an infinite countable set. This result is actually true for infinite vertex stabilizers and some more general, finite of infinite, edge stabilizers that we call highly core-free. We study the notion of highly core-free subgroups and give some examples. In the case of amalgamated free products over highly core-free subgroups and HNN extensions with highly core-free base groups we obtain a genericity result for faithful and highly transitive actions. In particular, we recover the result of D. Kitroser stating that the fundamental group of …

Vertex (graph theory)20B22 20E06 20E08Transitive relationApplied MathematicsGeneral Mathematics010102 general mathematicsamenable actionsHighly transitive actionsTransitive actionGroup Theory (math.GR)0102 computer and information sciences01 natural sciencesgroups acting on trees[MATH.MATH-GR]Mathematics [math]/Group Theory [math.GR]CombinatoricsMathematics::Group TheoryFree product010201 computation theory & mathematicsFOS: MathematicsMSC: Primary 20B22; Secondary 20E06 20E08 43A07Countable setHNN extension0101 mathematicsMathematics - Group TheoryMathematicsProceedings of the American Mathematical Society
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User requirements and resource control for cooperative multimedia applications

1997

The spread of distributed multimedia applications is setting forth a new set of challenges in the management of host and network resources for guaranteeing Quality of Service (QoS). When the multimedia applications compete for resources as in the case of a cooperative multimedia environment, the management task becomes even more difficult. In this work, we first discuss QoS for multimedia applications. We then present the architectural and implementation details of a Cooperative Multimedia Environment (CME) made up of Cooperative Multimedia Applications (COMMA), one for each user. A COMMA presents a user with a single interface that allows him to invite other users to a cooperative session,…

World Wide WebMultimediaComputer scienceInterface (Java)Quality of serviceIP Multimedia SubsystemWireless Multimedia ExtensionsSession (computer science)User requirements documentcomputer.software_genrecomputerHost (network)Task (project management)
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