Search results for " Effective"
showing 10 items of 380 documents
Interest of exome sequencing trio-like strategy based on pooled parental DNA for diagnosis and translational research in rare diseases.
2021
Abstract Background Exome sequencing (ES) has become the most powerful and cost‐effective molecular tool for deciphering rare diseases with a diagnostic yield approaching 30%–40% in solo‐ES and 50% in trio‐ES. We applied an innovative parental DNA pooling method to reduce the parental sequencing cost while maintaining the diagnostic yield of trio‐ES. Methods We pooled six (Agilent‐CRE‐v2–100X) or five parental DNA (TWIST‐HCE–70X) aiming to detect allelic balance around 8–10% for heterozygous status. The strategies were applied as second‐tier (74 individuals after negative solo‐ES) and first‐tier approaches (324 individuals without previous ES). Results The allelic balance of parental‐pool v…
Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review
2018
OBJECTIVE: To summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults. INTRODUCTION: Frailty is an age-related state of decreased physiological reserves characterized by an increased risk of poor clinical outcomes. Evidence supporting the malleability of frailty, its prevention and treatment, has been presented. INCLUSION CRITERIA: The review considered studies on older adults aged 65 and over, explicitly identified as pre-frail or frail, who had been undergoing interventions focusing on the prevention of frailty progression. Participants selected on the basis of specific illness or with a terminal diagnosis were …
A comprehensive fracture prevention strategy in older adults : The European union geriatric medicine society (EUGMS) statement
2016
Published also in Aging Clinical and Experimental Research, Vol.28, No.4, WOS: 000379034800030 Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest group on falls and fracture prevention of the European union geriatric medicine society (EUGMS), in collaboration with the International association of gerontology and geriatrics for the European region (IAGG-ER), the European union of medical specialists (EUMS), the Fragility fracture network (FFN), the International osteoporosis foundation (IOF) - European society for clinical and economic aspects …
Cost-effectiveness of a multi-professional case management experiment in Finnish labor market services
2020
The study undertook an economic evaluation of a multi-professional case man-agement intervention targeted at long-term unemployed Finns. The cost-effectiveness outcome of the intervention was analyzed in a matched case-control study framework involving a six-month follow-up. Effectiveness was measured by standardized quality of life indicators, and an indicator measuring personal capabilities. Individual level costs were derived from health and social services utilization data. Cost-effectiveness of the intervention was examined in relation to services as usual. The studied labor market intervention was associated with a positive change in the selected quality of life indicators; physical a…
Evaluation of efficacy and efficiency of a pragmatic intervention by a social worker to support informal caregivers of elderly patients (The ICE Stud…
2016
Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal caregivers composed of family, friends and neighbors, who are essential in helping older persons to continue living at home. It has been shown that the extent and diversity of informal tasks may jeopardize the physical, mental and social wellbeing of caregivers. The aim of the Informal Carers of Elderly cohort is to define, through a longitudinal study, profiles of caregivers of older patients with a diagnosis of one of the following diseases: cancer (breast, prostate, colorectal), neurode…
Perspektiven der Notfallmedizin f�r das 21. Jahrhundert
2001
die fehlende einheitliche Notrufnummer, die fehlende integrierende Leitstelle, die Novellierung der Rettungsassistentenausbildung und des Medizinkurrikulums oder die flachendeckende Etablierung des “arztlichen Leiters Rettungsdienst”. Diese und andere Versaumnisse mussen unverzuglich beseitigt werden. Teilweise existieren fur die adaquate Behandlung des Patienten mit komplexen notfallmedizinischen Krankheitsbildern (“golden hour diseases”) schon Behandlungskonzepte und auch Kalkulationen, die einen eindeutigen Nutzen dieser Behandlung sowohl im Outcome als auch in Lebensqualitat und Kosten-Nutzen-Relationen widerspiegeln. Diese Konzepte mussen weiterhin kompromisslos umgesetzt werden. Darub…
Measurement of the ratio ofBc+branching fractions toJ/ψπ+andJ/ψμ+νμfinal states
2014
The first measurement that relates semileptonic and hadronic decay rates of the B-c(+) meson is performed using proton-proton collision data corresponding to 1.0 fb(-1) of integrated luminosity collected with the LHCb detector. The measured value of the ratio of branching fractions, B(B-c(+) -> J/psi pi(+))/B(B-c(+) -> J/psi mu(+)nu(mu)) = 0.0469 +/- 0.0028(stat) +/- 0.0046(syst), is at the lower end of available theoretical predictions.
Factorization at Subleading Power, Sudakov Resummation and Endpoint Divergences in Soft-Collinear Effective Theory
2020
Starting from the first renormalized factorization theorem for a process described at subleading power in soft-collinear effective theory, we discuss the resummation of Sudakov logarithms for such processes in renormalization-group improved perturbation theory. Endpoint divergences in convolution integrals, which arise generically beyond leading power, are regularized and removed by systematically rearranging the factorization formula. We study in detail the example of the $b$-quark induced $h\to\gamma\gamma$ decay of the Higgs boson, for which we resum large logarithms of the ratio $M_h/m_b$ at next-to-leading logarithmic order. We also briefly discuss the related $gg\to h$ amplitude.
Dark matter, dark photon and superfluid He-4 from effective field theory
2020
We consider a model of sub-GeV dark matter whose interaction with the Standard Model is mediated by a new vector boson (the dark photon) which couples kinetically to the photon. We describe the possibility of constraining such a model using a superfluid He-4 detector, by means of an effective theory for the description of the superfluid phonon. We find that such a detector could provide bounds that are competitive with other direct detection experiments only for ultralight vector mediator, in agreement with previous studies. As a byproduct we also present, for the first time, the low-energy effective field theory for the interaction between photons and phonons.
How Effective are Business Ethics/CSR Courses in Higher Education?
2016
AbstractConcern is increasing worldwide for introducing dedicated courses on business ethics and Corporate Social Responsibility (CSR) in higher education curricula. In this study, awareness of business ethics is investigated from a sample of 307 undergraduate and postgraduate management students at a Polish university. This investigation aims at assessing management students’ awareness of business ethics issues, focusing on the potential differences in such perceptions depending on previous business ethics/CSR courses taken. Surprisingly, our results do not match prior findings in the extant literature. Notably, in our sample, having taken previous courses on business ethics/CSR does not p…