Search results for " Enhanced"
showing 10 items of 66 documents
Exploring the non-covalent ligand-binding mechanism on immunoproteasome by enhanced Molecular Dynamics
2021
Selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune and inflammatory diseases, and hematologic malignancies. In particular, non-covalent inhibition is strongly desirable because it is free of the drawbacks and side effects associated with covalent inhibition. Recently, a new series of amide derivatives with Ki values in the low/submicromolar ranges toward the β1i subunit have been identified as non-covalent inhibitors 1 . We investigated the binding mechanism of the most potent and selective inhibitor (1) to elucidate the steps from the ligand entrance into the binding pocket to the ligand-induced conformational changes. We carried out a total of 400ns of MD-…
La motivación de las tareas digitales mediante “pseudo-ApS” en Biología Celular del grado de Medicina
2020
[ES] Los grupos tutorizados de la asignatura “Biología” de 1º de Medicina (Universitat de València) son un entorno estupendo en el que desarrollas actividades que aúnen el carácter formativo conceptual con el desarrollo competencial transversal. Para ello, en el curso 19-20, hemos implementado la vinculación de la cuenta institucional UV con Microsoft 365, gracias al convenio existente entre ambas entidades para facilitar la utilización de las Tecnologías de la Información y la Comunicación (TICs) en la gestión del tiempo y del intercambio de información. Se propone a los alumnos la elaboración de objetos de aprendizaje propios y originales, en formato animación, que serán utilizados durant…
Enhancement of stability in systems with metastable states
2007
The investigation of noise‐induced phenomena in far from equilibrium systems is one of the approach used to understand the behaviour of physical and biological complex systems. Metastability is a generic feature of many nonlinear systems, and the problem of the lifetime of metastable states involves fundamental aspects of nonequilibrium statistical mechanics. The enhancement of the life‐time of metastable states through the noise enhanced stability effect and the role played by the resonant activation phenomenon will be discussed in models of interdisciplinary physics: (i) Ising model (ii) Josephson junction; (iii) stochastic FitzHugh‐Nagumo model; (iv) a population dynamics model, and (v) …
Nonlinear relaxation phenomena in metastable condensed matter systems
2016
Nonlinear relaxation phenomena in three different systems of condensed matter are investigated. (i) First, the phase dynamics in Josephson junctions is analyzed. Specifically, a superconductor-graphene-superconductor (SGS) system exhibits quantum metastable states, and the average escape time from these metastable states in the presence of Gaussian and correlated fluctuations is calculated, accounting for variations in the the noise source intensity and the bias frequency. Moreover, the transient dynamics of a long-overlap Josephson junction (JJ) subject to thermal fluctuations and non-Gaussian noise sources is investigated. Noise induced phenomena are observed, such as the noise enhanced s…
Stabilization Effects of Dichotomous Noise on the Lifetime of theSuperconducting State in a Long Josephson Junction
2015
We investigate the superconducting lifetime of a long overdamped current-biased Josephson junction, in the presence of telegraph noise sources. The analysis is performed by randomly choosing the initial condition for the noise source. However, in order to investigate how the initial value of the dichotomous noise affects the phase dynamics, we extend our analysis using two different fixed initial values for the source of random fluctuations. In our study, the phase dynamics of the Josephson junction is analyzed as a function of the noise signal intensity, for different values of the parameters of the system and external driving currents. We find that the mean lifetime of the superconductive…
Phase dynamics in graphene-based Josephson junctions in the presence of thermal and correlated fluctuations
2014
In this work we study by numerical methods the phase dynamics in ballistic graphene-based short Josephson junctions. The supercurrent through a graphene junction shows a non-sinusoidal phase-dependence, unlike a conventional junction ruled by the well-known d.c. Josephson relation. A superconductor-graphene-superconductor system exhibits superconductive quantum metastable states similar to those present in normal current-biased JJs. We explore the effects of thermal and correlated fluctuations on the escape time from these metastable states, when the system is stimulated by an oscillating bias current. As a first step, the analysis is carried out in the presence of an external Gaussian whit…
Lifetime of the superconductive state in long Josephson junctions in presence of non-Gaussian noise sources
2012
The effects of Lévy noise sources on the transient dynamics of long Josephson junctions (LJJ) are investigated in the presence of both a periodical current signal and a noise source with Gaussian, Cauchy-Lorentz or Levy-Smirnov probability distributions. In particular, by numerically integrating the Sine-Gordon equation, the mean escape time (MET) from the superconductive metastable state is obtained as a function both of the frequency of the periodical force and amplitude of the noise signal. We find resonant activation (RA) and noise enhanced stability (NES). Significative changes in RA and NES are observed by using Lévy noise sources with different statistics. MET is also studied as a fu…
Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules
2018
Background & Aims The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned because of the risk of a false positive diagnosis in cases of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS Liver Imaging Reporting and Data System [LI-RADS®]) to classify lesions at risk of HCC investigated by CEUS. The aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC. Methods A total of 1,006 nodules from 848 patients with chronic liver disease at risk of HCC were collected in five Italian centers and retrospectively analyzed. Nodules were classified as LR-5, (HCC) …
Analysis of soliton dynamics and noise induced effects on the superconductive lifetime in long Josephson junctions.
2013
The influence of various noise sources on the transient dynamics of long Josephson junctions (LJJ) is investigated in the presence of an oscillating bias current signal and a noise source with Gaussian or non-Gaussian (i.e. Cauchy-Lorentz or Lévy-Smirnov) probability distributions. These systems are computationally analyzed integrating the perturbed Sine-Gordon equation describing the phase evolution. We found evidence of noise induced effects on trends of the mean escape time (MET) from the superconductive metastable state, varying different system parameters, as the bias frequency, noise intensity and junction length. In particular, we find resonant activation (RA) and noise enhanced stab…
Transient dynamics in driven long Josephson junctions.
2013
The switching time from the superconductive metastable state of a long Josephson junction (LJJ)[1] is computationally analyzed in the framework of the perturbed sine-Gordon equation. The model includes an external bias current term and a stochastic noise source, i.e. a Lévy noise term. The effects of this noise on the mean escape time (MET) from the superconductive state are analyzed. The investigation is performed by considering a wide range of values of system parameters and different noise statistics: Gaussian, Cauchy-Lorentz and Lévy-Smirnov[2]. We found evidence of well known noise induced phenomena on the MET behavior, that is the noise enhanced stability (NES) and resonant activation…