Search results for " Eno"

The synthesis of fluorinated heteroaromatic compounds. Part 2. Five-membered rings with two heteroatoms. A review

2007

Role of endothelial cell stress in the pathogenesis of chronic heart failure.

2009

Endothelial cells are key modulators of diverse physiological processes, and their impaired function is a cause of numerous cardiovascular diseases. Under physiologic condition, the reactive oxygen and nitrogen mediators in endothelia lead to the signal propagation of the initial stimulus, by forming molecules with a longer half-life like hydrogen peroxide. Hydrogen peroxide is the focus of growing attention in endothelial biology, and consequently the enzymes involved in its generation and clearance are viewed as novel mediators of great importance. In particular, among peroxidases, myeloperoxidase is recognized as a key enzyme, capable of impairing intracellular NO reservoirs as well as p…

Role of matrix metalloproteases 2, 9 (MMP-2, -9), orphanin FQ and others peptides in vascular tone of human umbilical cord at term

2008

Umbilical cord is the structure that connects the fetus to the placenta. Umbilical cord at term is made of three vessels surrounded by the Wharton’s jelly, a mucous connective tissue rich in glycosaminoglycans, proteoglycans and different types of collagens and other microfibrils, which are responsible for its elasticity and its mechanical properties.Umbilical cord seems to lack any capillaries or lymphatics and umbilical vessels are unique in lacking any innervation; thus endothelial cells may play the major role in the local control of the blood flow. Objectives. In this paper we investigated in human umbilical cord at term the expression of some peptides involved in the regulation of the…

Lessons from the 2018-2019 European droughts : a collective need for unifying drought risk management

2022

Funding Information: This open-access publication was funded by the University of Freiburg. Funding Information: Financial support. The project is supported by the Wassernetzwerk Baden-Württemberg (Water Research Network of the State Baden-Württemberg), which is funded by the Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg (Ministry of Science, Research and the Arts of the State Baden-Württemberg) (grant no. AZ. 7532.21/2.1.6) and Maa-ja vesitekniikan tuki ry foundation. Doris E. Wendt acknowledges her support as part of the NERC-funded Groundwater Drought Initiative (NE/R004994/1). Lucy J. Barker was supported by the Natural Environment Research Council (NE/R016429/1) a…

Impiantistica enologica: verso una migliore qualità

2007

La filiera vitivinicola negli ultimi anni ha sviluppato nuove tecniche che hanno consentito un notevole miglioramento della qualità finale del prodotto. L'uso della tecnologia per ottenere la massima qualità del vino può iniziare già in campo, dopo la raccolta dell'uva, con un'appropriata esecuzione dei trasporti. Le macchine per la prima lavorazone (pigiatura e diraspatura) mostrano un'evoluzione costruttiva evidente; il rinnovamento delle macchine per la pressatura è il primo indicatore di un'evoluzione costante e sostanziale. La sostituzione delle presse orizzontali continue con presse pneumatiche a funzionamento discontinuo, rappresenta la volontà di ricercare un'estrazione delicata. Nu…

Yeast ecology of vineyards within Marsala wine area (western Sicily) in two consecutive vintages and selection of autochthonous Saccharomyces cerevis…

2012

In this work, the yeast ecology associated with the spontaneous fermentation of Grillo cultivar grapes from 10 vineyards was analyzed from grape harvest till complete consumption of must sugars. The microbiological investigation started with the plate count onto two culture media to distinguish total yeasts (TY) and presumptive Saccharomyces (PS). Yeasts were randomly isolated and identified by a combined genotypic approach consisting of restriction fragment length polymorphism (RFLP) of 5.8S rRNA gene and 26S rRNA and sequencing of D1/D2 domain of the 26S rRNA gene, which resulted in the recognition of 14 species belonging to 10 genera. The distribution of the yeasts within the vineyards s…

Ciklopentān-1,2,4-trionu sintēze un īpašības

2016

Ciklopentān-1,2,4-trionu sintēze un īpašības. Vēze K., darba vadītājs prof. Zicmanis A. Maģistra darbs, 37 lappuses, 28 attēli, 6 tabulas, 51 literatūras avots. Latviešu valodā. Darba literatūras apskatā apkopotas dažādas ciklopentān-1,2,4-trionu iegūšanas metodes – Klaizena kondensāciju, oksidēšanās un pārgrupēšanās reakcijas, halogēnsavienojumu hidrolīze. Eksperimentālajā daļā veikta četru dažādu ciklopentān-1,2,4-trionu sāļu sintēze. Azo-sametināšanas reakcijā ar četriem diazonija sāļiem un ciklopentān-1,2,4-triona nātrija sāli iegūtas krāsvielas. Veikta aizvietoto triketonu reakcija ar 2,4-dinitrofenilhidrazīnu.

An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated an…

2009

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a very poor 5-year survival rate. alpha-Enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor. We find that it is overexpressed in PDAC and present on the cell surface of PDAC cell lines. The clinical correlation of its expression with tumor status has been reported for lung and hepatocellular carcinoma. We have previously demonstrated that sera from PDAC patients contain IgG autoantibodies to alpha-enolase. The present work was intended to assess the ability of alpha-enolase to induce antigen-specific T cell responses. We show that alpha-enolase-pulsed dendritic cells (DC) specifically stimulate healt…

Dual Cherenkov Radiation-Induced Near-Infrared Luminescence Imaging and Photodynamic Therapy toward Tumor Resection

2020

International audience; Cherenkov radiation (CR), the blue light seen in nuclear reactors, is emitted by some radiopharmaceuticals. This study showed that (1) a portion of CR could be transferred in the region of the optical spectrum, where biological tissues are most transparent: as a result, upon radiance amplification in the near-infrared window, the detection of light could occur twice deeper in tissues than during classical Cherenkov luminescence imaging and (2) Cherenkov-photodynamic therapy (CR-PDT) on cells could be achieved under conditions mimicking unlimited depth using the CR-embarked light source, which is unlike standard PDT, where light penetration depth is limited in biologi…

Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism

2013

BackgroundWhether the oral factor Xa inhibitor edoxaban can be an alternative to warfarin in patients with venous thromboembolism is unclear. MethodsIn a randomized, double-blind, noninferiority study, we randomly assigned patients with acute venous thromboembolism, who had initially received heparin, to receive edoxaban at a dose of 60 mg once daily, or 30 mg once daily (e.g., in the case of patients with creatinine clearance of 30 to 50 ml per minute or a body weight below 60 kg), or to receive warfarin. Patients received the study drug for 3 to 12 months. The primary efficacy outcome was recurrent symptomatic venous thromboembolism. The principal safety outcome was major or clinically re…