Search results for " Eno"

showing 10 items of 60 documents

La resistenza di interfaccia calcestruzzo poroso-terreni a grana fina per il consolidamento di pendii mediante trincee drenanti profonde

2022

Le trincee drenanti profonde rappresentano uno dei metodi più efficaci per la mitigazione del rischio da frana, in pendii con falda idrica. Esse sono realizzate mediante pannelli o pali secanti. Il riempimento è costituito di calcestruzzo poroso o materiale granulare. Se le trincee sono adeguatamente “innestate” nel terreno stabile e il materiale di riempimento ha sufficiente resistenza e rigidezza come il calcestruzzo poroso, si ha ulteriore in-cremento di resistenza a taglio per effetto shear keys, oltre a quello derivante dalla riduzione delle pressioni in-terstiziali. L’incremento di resistenza è dovuto sia alla resistenza all’interfaccia calcestruzzo–terreni sia a quella intrinseca del…

interface shear strengthPervious concreteSettore ICAR/07 - Geotecnicashear keys effect. Pervious concrete for deep trench drains used to stabilise slopes must simultaneously satisfy many requirements namely adequate hydraulic conductiv-ity adequate shear strength a few days after pour-ing capacity to act as a protective filter for soils in which the drain is installed good resistance to clog-ging and adequate residual hydraulic conductivity. The pervious concrete with appropriated mix-design can effectively satisfy all the abovementioned requirements. If the trenches depth is such that they intersect the sliding surface and if the trenches are adequate-ly "socket" in the layers of stable soil there is a fur-ther increase in shear strength due to the shear keys effect. This latter is in addition to the increase in shear strength resulting from the reduction of inter-stitial pressures that remains the principal scope of the draining trenches. Obviously the increase of shear strength due to the shear keys effect occurs if the trenches are filled with material that have enough strength and stiffness such as the porous concrete. In this case the beneficial effects of the draining trenches on stability are also due to the resistance at the concrete interface of the trench - soils and to the intrinsic resistance of the concrete at the area of the trench intersected by the sliding surface taken into consideration.The increase in resistance due to the shear keys effect can be very significant in relation to the thickness and interspace of the trenches. Results reported in the paper demonstrated that the interface fine grained soil-pervious concrete is higher than the residual shear strength of the soil.
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Selective Synthesis of Z -Silyl Enol Ethers via Ni-Catalyzed Remote Functionalization of Ketones

2021

Journal of the American Chemical Society : JACS 143(22), 8375-8380 (2021). doi:10.1021/jacs.1c01797

ketonesSilylationDimerketonit010402 general chemistry01 natural sciencesBiochemistrytransition metalsCatalysisCatalysischemistry.chemical_compoundkatalyytitColloid and Surface ChemistryPolymer chemistryhydrocarbonsoligomerseetteritkemiallinen synteesiOlefin fiberGeneral ChemistrySilyl enol ether540Enolhiilivedyt3. Good health0104 chemical sciencesoligomeerietherschemistryChain walkingddc:540nikkeliSelectivityJournal of the American Chemical Society
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Studio delle popolazioni di lieviti di interesse enologico sull’isola di linosa

2011

lieviti mosto d'uva isola di linosapopolazioni di lieviti enologia Isola di linosa SiciliaSettore AGR/15 - Scienze E Tecnologie Alimentari
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Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis

2012

BACKGROUND & AIMS: We performed a randomized controlled trial to evaluate the safety and efficacy of enoxaparin, a low-molecular-weight heparin, in preventing portal vein thrombosis (PVT) in patients with advanced cirrhosis. METHODS: In a nonblinded, single-center study, 70 outpatients with cirrhosis (Child-Pugh classes B7-C10) with demonstrated patent portal veins and without hepatocellular carcinoma were assigned randomly to groups that were given enoxaparin (4000 IU/day, subcutaneously for 48 weeks; n = 34) or no treatment (controls, n = 36). Ultrasonography (every 3 months) and computed tomography (every 6 months) were performed to check the portal vein axis. The primary outcome was pre…

medicine.medical_specialtyCirrhosisIntention-to-treat analysisHepatologybusiness.industrycirrhosisGastroenterologyPortal vein trombosis; Enoxaparin; cirrhosisenoxaparin cirrhosis portal thrombosismedicine.diseasePortal vein trombosisSurgeryPortal vein thrombosislaw.inventionSpontaneous bacterial peritonitisModel for End-Stage Liver DiseaseRandomized controlled triallawHepatocellular carcinomaMedicinePortal hypertensionEnoxaparinbusinessGastroenterology
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Vaccination with ENO1 DNA Prolongs Survival of Genetically Engineered Mice with Pancreatic Cancer

2013

Background & Aims Pancreatic ductal adenocarcinoma (PDA) is an aggressive tumor, and patients typically present with late-stage disease; rates of 5-year survival after pancreaticoduodenectomy are low. Antibodies against α-enolase (ENO1), a glycolytic enzyme, are detected in more than 60% of patients with PDA, and ENO1-specific T cells inhibit the growth of human pancreatic xenograft tumors in mice. We investigated whether an ENO1 DNA vaccine elicits antitumor immune responses and prolongs survival of mice that spontaneously develop autochthonous, lethal pancreatic carcinomas. Methods We injected and electroporated a plasmid encoding ENO1 (or a control plasmid) into Kras G12D /Cre (KC) mice …

medicine.medical_treatmentDNA Vaccine; Enolase; Parnceratic cancer; Transgeneic miceEnolasegenetically engineered miceceEnzyme-Linked Immunosorbent AssayTransgeneic miceDNA vaccination03 medical and health sciencesMice0302 clinical medicineImmune systemPancreatic cancerGenetic modelmedicineVaccines DNADNA VaccineAnimalsSurvival rate030304 developmental biology0303 health sciencesImmunity CellularHepatologybiologyENO.1; DNA Vaccine; genetically engineered miceceVaccinationGastroenterologyParnceratic cancerImmunotherapyNeoplasms Experimentalmedicine.diseaseImmunohistochemistryMice Mutant Strains3. Good healthPancreatic NeoplasmsSurvival RateSettore BIO/18 - GeneticaTumor progression030220 oncology & carcinogenesisPhosphopyruvate HydrataseImmunologybiology.proteinAntibodyENO.1Carcinoma Pancreatic Ductal
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Scientific productivity and collaboration in viticulture and enology in Latin American countries

2013

[EN] The aim of this study was to analyze the scientific activity of Latin American researchers in viticulture and oenology through bibliometric analyses of articles included in the Science Citation Index Expanded database for the period of 2006 to 2010. A total of 917 research articles were published in 364 domestic and international journals. We highlight the important growth in the number of research papers published during the period, especially in Brazil, Argentina and Chile, as well as an increasing number of international collaborations, mainly with non-American grape- and-wine producing countries. A social network analysis of collaborations between institutions and countries was als…

scientific productivityscientific collaborationViticulture and enologyColaboración científicaTECNOLOGIA DE ALIMENTOSProductividad científicaPaíses de América LatinaFactor de impactoAnálisis de redesViticultura y enologíaScientific productivityviticulture and enologyLatin American countriesScientific collaborationPolitical scienceNetwork analysisImpact factorGeneral Agricultural and Biological Sciencesnetwork analysisCiencia e investigación agraria
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Enonciation animale : Franz Kafka, Primo Levi, le singe et la poule

2018

Cet articleessayera de discuter la question de l’énonciation animale à partir d’une perspective de recherche un peu plus étendue : celle qu’on a appelée d’une zoosemiotique 2.0 : c’est à dire une perspective sémiotique que, en outrepassant les recherches traditionnelles sur le langage et/ou la communication animale (inscrites dans une épistémologie naturaliste et scientiste), peut étudier l’animal ‘en situation’, acteur non-humain qui a des relations sociales (narrative, discursives) avec d’autres acteurs humaines et non humains. Plutôt que présupposer une différence de principe entre homme et animales, il faudrait donc rétablir les dispositifs sémiotiques à partir desquels ils se construis…

semiotica animali enunciazione discorso kafkasemiotique animales enonciation discours kafkaSettore M-FIL/05 - Filosofia E Teoria Dei Linguaggi
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Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action

2015

Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…

trypanosomiasisStereochemistrysleeping sicknessCathepsin LDrug Evaluation PreclinicalChemistry Techniques SyntheticInhibition kineticsCysteine Proteinase InhibitorsBiochemistryCathepsin BInhibitory Concentration 50Structure-Activity RelationshipinhibitorsDrug DiscoveryHumansMoietyMolecular Targeted TherapyGeneral Pharmacology Toxicology and PharmaceuticsIC50Volume concentrationrhodesainPharmacologyChemistryOrganic ChemistryDual modeDipeptidesTrypanocidal AgentsCombinatorial chemistryMolecular Docking SimulationCysteine EndopeptidasesKineticsdipeptidyl enoatesTrypanosomiasis AfricanDocking (molecular)Molecular MedicineCysteine thiolateChemMedChem
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2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

2020

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

unstable anginaMyocardial ischaemia[SDV]Life Sciences [q-bio]Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]dual antithrombotic therapyGuidelineheparin030204 cardiovascular system & hematologyPlatelet inhibitionantiplatelet0302 clinical medicineST segmentMedicinedabigatranMyocardial infarctionguidelinesglycoprotein iib/iiia inhibitorsanticoagulationNon-ST Elevated Myocardial InfarctionrivaroxabanComputingMilieux_MISCELLANEOUSreproductive and urinary physiologydiabetesbleedingsbivalirudinatherothrombosiDisease ManagementangioplastyGuidelines • acute cardiac care • acute coronary syndrome • angioplasty • anticoagulation • antiplatelet • apixaban • aspirin • atherothrombosis • betablockers • bleedings • bivalirudin • bypass surgery • cangrelor • chest pain unit • clopidogrel • dabigatran • diabetes • dual antithrombotic therapy • early invasive strategy • edoxaban • enoxaparin • European Society of Cardiology • fondaparinux • glycoprotein IIb/ IIIa inhibitors • heparin • high-sensitivity troponin • minoca • myocardial ischaemia • myocardial infarction • nitrates • non-ST-elevation myocardial infarction • platelet inhibition • prasugrel • recommendations • revascularization • rhythm monitoring • rivaroxaban • stent • ticagrelor • triple therapy • unstable anginaenoxaparinGeneral MedicineClopidogrel3. Good healthearly invasive strategymyocardial infarctiontriple therapy030220 oncology & carcinogenesisHigh sensitivity troponinembryonic structuresCardiologyPlatelet aggregation inhibitorrevascularizationbiological phenomena cell phenomena and immunityCardiology and Cardiovascular MedicineTicagrelormedicine.drugHumanrecommendationAcute coronary syndromemedicine.medical_specialtyaspiringlycoprotein IIb/IIIa inhibitornon-ST-elevation myocardial infarctionapixabanrhythm monitoringEuropean Society of Cardiologyticagrelor03 medical and health sciencesnitrateatherothrombosisbetablockersInternal medicineacute cardiac careminocachest pain unitDiseases of the circulatory (Cardiovascular) systemHumansIn patientAcute Coronary SyndromeclopidogrelUnstable anginaurogenital systemnitratesbusiness.industryfondaparinuxbetablockerArrhythmias Cardiac030229 sport sciencesbleedingmedicine.diseasemyocardial ischaemiaplatelet inhibitionprasugreldiabeteGlycoprotein IIb/IIIa inhibitorsRC666-701bypass surgerySettore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARErecommendationsedoxabanhigh-sensitivity troponinstentbusinessPlatelet Aggregation Inhibitorscangrelor
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Dzīvības koka motīvs 1 En 24:2–25:7

2022

Darba “Dzīvības koka motīvs 1 En 24:2 – 25:7” mērķis ir noskaidrot, kā izprotams 1 En 24:2 – 25:7 aprakstītais koks un kādi ir argumenti šī koka saistīšanai ar dzīvības vai pēc dažu pētnieku domām saistīšanai ar gudrības koku. Darbā izvirzītā tēze – 1 En 24:2 – 25:7 aprakstītais koks, kura iezīmes citos 3. gs. BC – 1. gs. AD tekstos netiek atainotas līdzīgā kontekstā, sevī savieno kā dzīvības, tā gudrības (zināšanu) motīvu, tādejādi plašāk attīstot Gen 2 – 3 aizsākto tradīciju, kokam piešķirot eshatoloģisku nozīmi. Darba gaitā tēze apstiprinās caur veikto 1 En 24:2 – 25:7 eksegēzi, citu Kumrānas rokrakstu, kas ietver Ēdenes dārza motīvu, aplūkošanu un pētnieku viedokļu par šajā perikopē att…

Ēdenes dārzsdzīvības kokslaba un ļauna atzīšanas koksTeoloģija un reliģiju zinātneLevī Testaments1. Enoha grāmata
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