Search results for " Eosinophil"

showing 10 items of 57 documents

The Severe Asthma Network in Italy: Findings and Perspectives

2019

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by accredited centers on severe asthma. Objective To analyze epidemiological, clinical, inflammatory, functional, and treatment characteristics of severe asthmatics from the SANI registry. Methods All consecutive patients with severe asthma were included into the registry, without exclusion criteria to have real-life data on demographics, asthma control, treatments (including biologics), inflammatory biomarkers, and comorbidities. Results A total of 437 patients (mean age: 54.1 years, 57.2% females, 70.7% atopics, 94.5% in Global Initiative for Asthma severity step V) were enrolled into the study. The mean …

AdultMalemedicine.medical_specialtyRegistrySevere asthmaExacerbationBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Immunology and AllergyOmalizumabComorbiditySettore MED/10 - Malattie Dell'Apparato RespiratorioComorbiditiesAtopy03 medical and health sciencesBronchiectasi0302 clinical medicineFood allergyInternal medicineLate-onset asthmaNasal polypsBronchiectasis; Comorbidities; Late-onset asthma; Nasal polyps; Registry; SANI; Severe asthma; Adult; Aged; Asthma; Bronchiectasis; Comorbidity; Eosinophils; Female; Humans; Immunoglobulin E; Italy; Male; Middle Aged; Nasal Polyps; Registries; RhinitisMedicineHumansBronchiectasis Comorbidities Late-onset asthma Nasal polyps Registry SANI Severe asthma Immunology and AllergyImmunology and Allergy030212 general & internal medicineRegistriesAsthmaAgedRhinitisBronchiectasisbusiness.industryNasal polypSANIImmunoglobulin EMiddle Agedmedicine.diseaseAsthmaBronchiectasisEosinophils030228 respiratory systemItalyAsthma Control QuestionnaireFemaleComorbiditiebusinessMepolizumabmedicine.drug
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Fecal assays detect hypersensitivity to cow's milk protein and gluten in adults with irritable bowel syndrome.

2011

Background & Aims Some patients with irritable bowel syndrome (IBS)-like symptoms suffer from food hypersensitivity (FH); their symptoms improve when they are placed on elimination diets. No assays identify patients with FH with satisfactory levels of sensitivity. We determined the frequency of FH among patients with symptoms of IBS and the ability of fecal assays for tryptase, eosinophil cationic protein (ECP), or calprotectin to diagnose FH. Methods The study included 160 patients with IBS, 40 patients with other gastrointestinal diseases, and 50 healthy individuals (controls). At the start of the study, patients completed a symptom severity questionnaire, fecal samples were assayed, and …

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaFecal Calprotectin.AdolescentGlutensTryptaseWheat HypersensitivityGastroenterologyIrritable Bowel SyndromePlacebosFecesYoung Adultfluids and secretionsDouble-Blind MethodInternal medicineElimination dietmedicineHumansIrritable bowel syndromeFeceschemistry.chemical_classificationEosinophil cationic proteinHepatologybiologybusiness.industryOral food challengeEosinophil Cationic ProteinGastroenterologyMiddle Agedmedicine.diseaseGlutenDietchemistryGluten SensitivityImmunologybiology.proteinFemaleTryptasesCalprotectinCow’s Milk Protein HypersensitivityMilk HypersensitivitybusinessLeukocyte L1 Antigen ComplexCow’s Milk Protein Hypersensitivity; Gluten Sensitivity; Fecal Tryptase; Fecal Eosinophil Cationic Protein; Fecal Calprotectin.Fecal TryptaseFecal Eosinophil Cationic ProteinClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
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Higher blood eosinophil levels after omalizumab treatment may be associated with poorer asthma outcomes

2019

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaTreatment outcomeMEDLINEOmalizumabOmalizumabSettore MED/10 - Malattie Dell'Apparato RespiratorioImmunoglobulin Eeosinophil Omalizumab anti-IgE asthmaLeukocyte CountText miningForced Expiratory VolumeInternal medicineEosinophiliamedicineHumansImmunology and AllergyAnti-Asthmatic AgentsBlood eosinophilAgedRetrospective StudiesAsthmabiologybusiness.industryRetrospective cohort studyMiddle AgedasthmaPrognosismedicine.diseaseEosinophilsTreatment Outcomeinflammationbiology.proteinFemalebusinessmedicine.drug
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Effects of Omalizumab Treatment in Patients With Recalcitrant Nasal Polyposis and Mild Asthma: A Multicenter Retrospective Study

2021

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a clinical entity with specific features that impacts significantly on patient quality of life (QoL). CRSwNP is often associated with asthma and is difficult to control and manage despite pharmacological and/or surgical treatment. Omalizumab, a monoclonal anti-IgE antibody, has emerged as a putative therapeutic option. Objective To evaluate the effects of omalizumab on nasal polyp (NP) size and QoL assessed by Sino-Nasal Outcome Test-22 (SNOT-22) in patients with recalcitrant CRSwNP and mild asthma. Methods A multicenter retrospective analysis of patient data from the Community of Valencia (Spain) was performed. Adult patients …

Adultmedicine.medical_specialtyMild asthmaOmalizumabOmalizumabaspirin-exacerbated respiratory diseasechronic rhinosinusitis with nasal polypsImmunoglobulin E03 medical and health sciencesNasal Polyps0302 clinical medicineQuality of lifeSNOT-22Internal medicinemedicineHumansImmunology and AllergyNasal polypsIn patient030223 otorhinolaryngologyRetrospective StudiesRhinitisnasal polypsbiologybusiness.industrytotal nasal endoscopic polyp scoreRetrospective cohort studyGeneral Medicinemedicine.diseaseAsthmaTreatment Outcomequality of lifetissue eosinophilia030228 respiratory systemOtorhinolaryngologyIgE SNOT-22 aspirin-exacerbated respiratory disease chronic rhinosinusitis with nasal polyps mild asthma nasal polyps omalizumab quality of life tissue eosinophilia total nasal endoscopic polyp scoreChronic DiseaseQuality of Lifebiology.proteinomalizumabAspirin exacerbated respiratory diseaseIgEbusinessmild asthmamedicine.drugAmerican Journal of Rhinology & Allergy
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Nasal IgE in subjects with allergic and non-allergic rhinitis

2020

Abstract Purpose The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students. Methods 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-fo…

AllergyNon-allergic rhinitismedicine.medical_treatmentImmunoglobulin EAR + HDM allergic rhinitis with house dust mite allergyAllergic rhinitisHDM house dust miteNPT nasal provocation testsAR allergic rhinitis0302 clinical medicineISAAC International Study of Asthma and Allergies in Childhood questionnaireNARES non-allergic rhinitis with eosinophilia-syndromeMedicine and Health SciencesImmunology and Allergy030223 otorhinolaryngologyeducation.field_of_studybiologymedicine.diagnostic_testRadioallergosorbent testsIgE allergen-specific IgENon-allergicD1 Dermatophagoides pteronyssinusPREVALENCED2 Dermatophagoides farinaeLAR local allergic rhinitisPROVOCATION TESTSPulmonary and Respiratory Medicinelcsh:Immunologic diseases. AllergyLOCAL IGEImmunologyPopulationPATHOPHYSIOLOGYNon-allergic-rhinitisLocal allergic rhinitisGCP Good Clinical PracticeDIAGNOSISNasal provocation testArticleSECRETIONS03 medical and health sciencesFEV1/FVC ratiorhinitismedicineddc:610educationHouse dust mitebusiness.industryFEV1 forced expiratory volume in one secondRAST Radioallergosorbent Testbiology.organism_classificationmedicine.disease030228 respiratory systemHouse dust mite allergyPNIF peak nasal inspiratory flowImmunologyFVC forced vital capacitybiology.proteinbusinessSD standard deviationlcsh:RC581-607Local IgESPT skin prick testWorld Allergy Organization Journal
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Systemic schistosomiasis and large bowel perforation: An unexpected surgical urgency. Report of a case and literature review

2019

Key Clinical Message In the presence of suggestive clinical picture (high eosinophil count and multiple CT scan granuloma‐like lesions), schistosomiasis should be taken into account in case of suspected bowel perforation even if common risk factors are not identified through anamnesis.

Anamnesismedicine.medical_specialtyHigh eosinophil countmedicine.diagnostic_testbusiness.industryCase ReportSchistosomiasisComputed tomographyCase ReportsGeneral MedicineBowel perforation030204 cardiovascular system & hematologymedicine.disease03 medical and health sciences0302 clinical medicineEmergency surgery030220 oncology & carcinogenesiscolonic perforationMedicineRadiologyemergency surgerysystemic schistosomiasisbusinessClinical Case Reports
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Iperreattività bronchiale aspecifica in pazienti monosensibili con rinite allergica: variazioni stagionali in rapporto alle IgE sieriche totali ed ag…

2005

Introduction: The significance of the association between allergic rhinitis and abnormal airway responsiveness is unclear. For this reason, we have studied, in patients with seasonal allergic rhinitis, non specific bronchial hyperreactivity, total serum IgE and blood eosinophils, with reference to the responsible allergen, during and out of the pollen season. Materials and methods: Fourty-nine, non-smoking patients, living in Palermo, with clinical diagnosis of allergic rhinitis, skin prick tests and specific serum IgE mono-sensitive to pollen allergens, were enrolled in the study. Twenty patients suffered from seasonal rhinitis to Parietaria pollen, 15 patients to Graminacee pollen and 14 …

Blood eosinophils countNon specific bronchial hyperreactivitySeasonal allergic rhinitiTotal serum IgEPC20-FEV1
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CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children.

2005

BACKGROUND In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4(+)IL-13(+) and the clinical phase of extrinsic AD in children. METHODS Twenty children with AD were studied. Assessed parameters were: clinical severity (SCORAD index), total serum immunoglobulin E (IgE), blood eosinophil count, and percentage of CD4(+)IFNgamma(+), CD4(+)IL-4(+), CD4(+)IL-13(+) T cells. Determinations were carried out in the acute phase and after clinical remission were achieved. Ten nonatopic-matched children served as controls. RESULTS At baselin…

CD4-Positive T-LymphocytesMaleAllergyImmunologyCD4 T cellsEosinophilSettore MED/10 - Malattie Dell'Apparato Respiratoriointerleukin-13Immunoglobulin ESeverity of Illness IndexDermatitis AtopicSettore MED/13 - EndocrinologiaAtopyLeukocyte CountImmunopathologymedicineHumansImmunology and AllergySCORADChildmedicine.diagnostic_testbiologyatopic dermatitisbusiness.industrySeverity of Illness Index; Interleukin-13; Dermatitis Atopic; Humans; Child; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Leukocyte Count; Child Preschool; Eosinophils; Immunoglobulin E; Case-Control Studies; Female; MaleInterleukinallergy; atopic dermatitis; CD4 T cells; interleukin-13; Th1/Th2 cellsAtopic dermatitisEosinophilImmunoglobulin Emedicine.diseaseallergyCD4 Lymphocyte CountEosinophilsmedicine.anatomical_structureCD4-Positive T-LymphocyteCase-Control StudiesChild PreschoolImmunologybiology.proteinFemaleTh1/Th2 cellsbusinessCase-Control StudieHuman
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Inhibitory effects of N-acetylcysteine on the functional responses of human eosinophils in vitro

2007

Background Oxidative stress appears to be relevant in the pathogenesis of inflammation in allergic diseases like bronchial asthma. Eosinophils are oxidant-sensitive cells considered as key effectors in allergic inflammation. Objective The aim of this work was to study the effects of the clinically used antioxidant N-acetyl-L-cysteine (NAC) on the functional responses of human-isolated eosinophils. Methods Human eosinophils were purified from the blood of healthy donors by a magnetic bead separation system. The effects of NAC were investigated on the generation of reactive oxygen species (chemiluminescence and flow cytometry), Ca2+ signal (fluorimetry), intracellular glutathione (GSH; flow c…

Chemokine CCL11EotaxinLuminescenceImmunologyhuman eosinophilsBiologyPharmacologymedicine.disease_causeTranslocation GeneticAllergic inflammationAcetylcysteinechemistry.chemical_compoundmedicineHumansImmunology and Allergychemistry.chemical_classificationreactive oxygen speciesEosinophil cationic proteinReactive oxygen speciesCell DeathEosinophil Cationic ProteinNADPH OxidasesFree Radical ScavengersGlutathioneEosinophilPhosphoproteinsGlutathioneN-acetylcysteineAcetylcysteineEosinophilsN-Formylmethionine Leucyl-Phenylalaninemedicine.anatomical_structurechemistryBiochemistryChemokines CCeosinophil cationic proteinCalciumReactive Oxygen SpeciesOxidative stressp47(phox)medicine.drugp67(phox)
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Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia.

2003

Abstract Most infections with respiratory viruses induce Th1 responses characterized by the generation of Th1 and CD8+ T cells secreting IFN-γ, which in turn have been shown to inhibit the development of Th2 cells. Therefore, it could be expected that respiratory viral infections mediate protection against asthma. However, the opposite seems to be true, because viral infections are often associated with the exacerbation of asthma. For this reason, we investigated what effect an influenza A (flu) virus infection has on the development of asthma. We found that flu infection 1, 3, 6, or 9 wk before allergen airway challenge resulted in a strong suppression of allergen-induced airway eosinophil…

ChemokineEpitopes T-LymphocyteImmunoglobulin Emedicine.disease_causeMiceCell MovementInfluenza A virusImmunology and AllergyEosinophiliaChemokine CCL5LungCells CulturedChemokine CCL2Mice KnockoutMice Inbred BALB Cbiologymedicine.diagnostic_testrespiratory systemUp-Regulationmedicine.anatomical_structureInfluenza A virusChemokines CCGoblet CellsNippostrongylusmedicine.symptomBronchial HyperreactivityChemokine CCL11OvalbuminImmunologyDown-RegulationMice TransgenicCCL5VirusInterferon-gammaTh2 CellsOrthomyxoviridae InfectionsLymphopeniamedicineAnimalsLymphocyte CountPulmonary EosinophiliaStrongylida InfectionsGoblet cellMetaplasiaAllergensPeptide Fragmentsrespiratory tract diseasesMice Inbred C57BLBronchoalveolar lavageImmunologyCell Migration Inhibitionbiology.proteinInterleukin-5Journal of immunology (Baltimore, Md. : 1950)
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