Search results for " Ep"

COVID‐19 in older adults: What are the differences with younger patients?

2020

Aim The present study aimed both to gain knowledge on the distinctive clinical characteristics of older adults with coronavirus disease 2019 (COVID‐19), in comparison with those of younger patients, and to identify risk factors for mortality. Methods A retrospective observational study was carried out of patients consecutively admitted to Doctor Peset University Hospital, Valencia (Spain) for COVID‐19 from 11 March to 28 April 2020. Every case was diagnosed by reverse transcription polymerase chain reaction or by serology test to detect antibodies. Demographic details, clinical characteristics, laboratory findings on admission and complications of each case were collected from electronic me…

Radzenes un epitēlija biezuma mērījumu atkārtojamība ar optiskās koherences tomogrāfiju

2021

Darbs ir uzrakstīts latviešu valodā uz 31 lapaspuses. Tas satur 14 attēlus, 10 tabulas un 44 atsauces uz literatūras avotiem. Darba mērķis: novērtēt mērījumu atkārtojamību HOCT-1 ierīcei un izstrādāt ieteikumus turpmākajiem radzenes pētījumiem, izmantojot šo ierīci. Metode: Divu ražotāju SD-OCT ierīcēm – Maestro 3D un HOCT-1 - tika analizētas radzenes (RB) un epitēlija (REB) biezuma kartes centrā un 8 paracentrālos sektoros. Mērījumu atkārtojamība tika noteikta aprēķinot starp mērījumu standarta novirzi, variācijas koeficientu un starpklašu korelācijas koeficientu. Rezultāti: HOCT-1 ierīce nodrošina labu atkārtojamību RB mērījumiem centrā un vidēji labu paracentrālos sektoros. REB mērījumie…

PREPARAZIONE E CARATTERIZZAZIONE DI NANOSISTEMI LIPIDICI PER IL DIREZIONAMENTO E IL RILASCIO MODIFICATO DI FARMACI E ACIDI NUCLEICI IN TERAPIA ONCOLO…

2016

sono stati sviluppati sistemi nanoparticellari in grado di intrappolare elevate quantità di farmaci e di legare materiale genico. I sistemi preparati sono stati caratterizzati da un punto di vista chimico-fisico e tecnologico farmaceutico. Sono stati infine utilizzati per prove in vitro e i risultati ottenuti hanno mostrato che essi possiedono le caratteristiche per potere essere considerati dei validi carrier per farmaci e materiale genico nel trattamento oncologico.

Biocompatible Lipid Nanoparticles as Carriers to Improve Curcumin Efficacy in Ovarian Cancer Treatment

2017

Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumoral activity of curcumin, by entrapping it into nanostructured lipid carriers (NLCs). For this purpose here we describe the preparation and characterization of three kinds of curcumin-loaded NLCs. The nanosystems allowed the achievement of a controlled release of curcumin, the amounts of curcumin r…

RNA memory

2011

In the last decade non-coding RNAs (ncRNAs) have emerged as cellular key regulators. The attention of the scientific community has focused on ncRNAs with repressive features on eukaryotic transcriptional regulation. Many experimental evidences suggest that ncRNAs could also positively regulate transcription. The RNA-Memory Model (Arancio W. Rejuvenation Res. 2010 Apr-Jun;13(2-3):365-72.) gives possible explanations to several biological phenomena via trans-acting ncRNAs (memRNAs) able to orchestrate chromatin remodelling and in turn enhance transcription. memRNAs assert their functions especially during the post-mitotic chromatin remodelling. memRNAs can mark the genes transcribed in the mo…

Caratterizzazione delle neoplasie epatiche benigne: ecografia ad inversione impulso con mezzo di contrasto di I e II generazione a confronto

2006

N-ACETYL-ASPARTATE ABNORMALITIES IN INTERNAL-TEMPORAL EPILEPTICUS FOCUS USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY

1995

International audience; Abstract: The aim of this study was to characterize the neurochemical abnormalities related to N-acetyl-aspartate which is a neuronal marker, within an epilepticus focus located in the internal-temporal area, using proton magnetic resonance spectroscopy, Eleven patients,with a mono-hippocampal epilepticus focus on clinical and per-critical electroencephalographical criteria, were matched with II controls by age, sex and laterality. Proton spectroscopy of a volume of 8 cm(3) was performed within the ipsilateral and the contralateral internal-temporal area and within the 2 hippocampus of controls. Volumetry of the ipsilateral and the contralateral hippocampus and of th…

Setting the basis for the study of intermediate conformers of human neuroserpin by Double Electron Electron Resonance

2012

The Double Electron Electron Resonance (DEER) is an innovative technique that allows to measure the distance distribution between two spin labels within a range of 2-8 nm. This technique does not require crystalline samples, thus it is possible to determine the position of two different spin labelled domains of intrinsically flexible macromolecular systems. Our idea is to determinate the structural details of the intermediate conformers of human neuroserpin (hNS) by DEER. hNS is a protein that in the native state is folded in a metastable conformation. In particular conditions, hNS can either adopt a more stable conformation with the reactive centre loop (RCL) inserted into a β-sheet (laten…

New orbital ephemerides for the dipping source 4U 1323-619: Constraining the distance to the source

2016

4U 1323-619 is a low mass X-ray binary system that shows type I X-ray bursts and dips. The most accurate estimation of the orbital period is 2.941923(36) hrs and a distance from the source that is lower than 11 kpc has been proposed. We aim to obtain the orbital ephemeris, the orbital period of the system, as well as its derivative to compare the observed luminosity with that predicted by the theory of secular evolution. We took the advantage of about 26 years of X-ray data and grouped the selected observations when close in time. We folded the light curves and used the timing technique, obtaining 12 dip arrival times. We fit the delays of the dip arrival times both with a linear and a quad…

Saturation and forward jets in proton-lead collisions at the LHC

2019

We investigate the forward-jet energy spectrum within the Color Glass Condensate framework at 5 TeV center-of-mass energy. In particular, we focus on the kinematic range covered by the CMS-CASTOR calorimeter. We show that our saturation-model calculations are compatible with the CASTOR measurements and that to optimally reproduce the data, effects of multi-parton interactions need to be included. We predict a significant nuclear suppression - reaching down to 50% at the lowest considered jet energies $E_{\rm jet} \sim 500 \, {\rm GeV}$.