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showing 10 items of 1034 documents

Contrast ultrasound LI-RADS LR-5 identifies hepatocellular carcinoma in cirrhosis in a multicenter restropective study of 1,006 nodules

2018

Background & Aims The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned because of the risk of a false positive diagnosis in cases of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS Liver Imaging Reporting and Data System [LI-RADS®]) to classify lesions at risk of HCC investigated by CEUS. The aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC. Methods A total of 1,006 nodules from 848 patients with chronic liver disease at risk of HCC were collected in five Italian centers and retrospectively analyzed. Nodules were classified as LR-5, (HCC) …

Liver CirrhosisMaleCirrhosisContrast enhanced ultrasoundContrast MediaChronic liver diseaseGastroenterology030218 nuclear medicine & medical imagingCholangiocarcinoma0302 clinical medicineDiagnosisMedicineTomographyWashoutUltrasonographyUltrasoundLiver NeoplasmsMiddle AgedMagnetic Resonance ImagingX-Ray ComputedLiverHepatocellular carcinoma030211 gastroenterology & hepatologyFemaleRadiologymedicine.symptomAlgorithmsContrast-enhanced ultrasoundAdultmedicine.medical_specialtyCarcinoma HepatocellularDiagnosis Differential03 medical and health sciencesInternal medicineHumansDiagnostic ErrorsneoplasmsAgedLiver Imaging Reporting And Data System (LI-RADS)Hepatologybusiness.industryCarcinomaSettore MED/09 - MEDICINA INTERNAReproducibility of ResultsHepatocellularRetrospective cohort studyHistologyNodule (medicine)medicine.diseaseImage Enhancementdigestive system diseasesArterial hyperenhancementDifferentialbusinessTomography X-Ray Computed
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The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency

2013

Objectives: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is developing a computer-adaptive test (CAT) version of the EORTC Quality of Life Questionnaire (QLQ-C30). We evaluated the measurement properties of the CAT versions of physical functioning (PF) and fatigue (FA) and compared these with the corresponding QLQ-C30 scales. Study Design and Setting: Based on international samples of more than 1,000 cancer patients, we simulated CAT administration of varying numbers of items and compared the resulting scores with those based on all items in the respective item pools. Furthermore, the relative validity (RV) of CATs was compared with that of th…

MESH: FatigueMaleEpidemiologyMESH: Aged 80 and over0302 clinical medicinePhysical functioningQuality of lifeNeoplasmsSurveys and QuestionnairesActivities of Daily LivingStatisticsMESH: NeoplasmsDiagnosis Computer-Assisted030212 general & internal medicineFatigueReliability (statistics)MathematicsMESH: AgedAged 80 and overMESH: Middle AgedMiddle Agedhumanities3. Good healthMESH: Reproducibility of ResultsLevel of measurementMESH: Young AdultData Interpretation Statistical030220 oncology & carcinogenesis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleAdultmedicine.medical_specialtyAdolescentMean squared errorSensitivity and SpecificityYoung Adult03 medical and health sciencesSDG 3 - Good Health and Well-beingotorhinolaryngologic diseasesmedicineHumansMESH: Surveys and QuestionnairesAgedMESH: AdolescentMESH: HumansMESH: Activities of Daily LivingMESH: Diagnosis Computer-AssistedMESH: Quality of LifeReproducibility of ResultsMESH: Adultsocial sciencesMESH: MaleMESH: Sensitivity and SpecificitySample size determinationQuality of LifePhysical therapy[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieComputerized adaptive testingMESH: Data Interpretation StatisticalMESH: FemaleRelative validity
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Rapid Evaluation of Oxidized Fatty Acid Concentration in Virgin Olive Oils Using Metal Oxide Semiconductor Sensors and Multiple Linear Regression

2009

This works aims to set up a rapid and nondestructive method to evaluate the advanced oxidation of virgin olive oils (VOOs). An electronic nose based on an array of six metal oxide semiconductor sensors was used, jointly with multiple linear regression (MLR), to predict the oxidized fatty acid (OFA) concentration in VOO samples characterized by different oxidative status. An MLR model constructed using five predictors was able to predict OFA concentration with an average validation error of 9%.

MULTIPLE LINEAR REGRESSIONBiosensing TechniquesVIRGIN OLIVE OILMetalOxide semiconductorVIRGIN OLIVE OILSMETAL OXIDE SEMICONDUCTOR SENSORSLinear regressionPlant OilsOrganic chemistryValidation errorOlive Oilchemistry.chemical_classificationChromatographyElectronic noseOXIDATIVE STATUSFatty AcidsELECTRONIC NOSEFatty acidOxidesGeneral ChemistryOXIDIZED FATTY ACIDSVegetable oilSemiconductorschemistryvisual_artLinear Modelsvisual_art.visual_art_mediumGeneral Agricultural and Biological SciencesOxidation-ReductionOlive oil
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Data Augmentation for Pipeline-Based Speech Translation

2020

International audience; Pipeline-based speech translation methods may suffer from errors found in speech recognition system output. Therefore, it is crucial that machine translation systems are trained to be robust against such noise. In this paper, we propose two methods for parallel data augmentation for pipeline-based speech translation system development. The first method utilises a speech processing workflow to introduce errors and the second method generates commonly found suffix errors using a rule-based method. We show that the methods in combination allow significantly improving speech translation quality by 1.87 BLEU points over a baseline system.

Machine translationComputer sciencePipeline (computing)media_common.quotation_subjectSpeech recognition[INFO.INFO-LG] Computer Science [cs]/Machine Learning [cs.LG]speech translationSpeech processingcomputer.software_genreneural machine translation[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL]robustness to errorsWorkflow[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG][INFO.INFO-CL] Computer Science [cs]/Computation and Language [cs.CL]Speech translationQuality (business)Noise (video)Suffixcomputermedia_commonHuman Language Technologies – The Baltic Perspective - Proceedings of the Ninth International Conference Baltic HLT 2020
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Semantic Word Error Rate for Sentence Similarity

2016

Sentence similarity measures have applications in several tasks, including: Machine Translation, Paraphrase Iden- tification, Speech Recognition, Question-answering and Text Summarization. However, measures designed for these tasks are aimed at assessing equivalence rather than resemblance, partly departing from human cognition of similarity. While this is reasonable for these activities, it hinders the applicability of sentence similarity measures to other tasks. We therefore propose a new sentence similarity measure specifically designed for resemblance evaluation, in order to cover these fields better. Experimental results are discussed.

Machine translationComputer scienceSpeech recognitionWord error rate02 engineering and technologycomputer.software_genreParaphrase030507 speech-language pathology & audiology03 medical and health sciencesSemantic similarityArtificial IntelligenceLSAWord Error Rate0202 electrical engineering electronic engineering information engineeringsentence resemblanceEquivalence (formal languages)Latent Semantic AnalysiSemantic Word Error Ratesentence similarity measureSWERbusiness.industryLatent semantic analysisSentence SimilaritySemantic ComputingCognitionAutomatic summarizationComputer Networks and Communicationword relatedne020201 artificial intelligence & image processingArtificial intelligence0305 other medical sciencebusinesscomputerNatural language processingWERInformation Systems2016 IEEE Tenth International Conference on Semantic Computing (ICSC)
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Has 1997 Asian crisis increased information flows between international markets

2003

Abstract The Asian crisis started on July 2, 1997 and caused turmoil in developed as well as emerging international stock markets. The objective of this paper is to analyse the effects of the crisis on the relationships of the Southeast Asian stock markets with the stock markets of three geographical areas (Europe, North America, and Latin America). We use the Morgan Stanley national and international indexes (MSCI) for two homogeneous and nonoverlapping time intervals. The econometric techniques used in this paper include the cointegration test, vector autoregression analysis, forecast error variance decomposition (FEVD), and impulse–response relationships. Our results show that: (i) there…

MacroeconomicsInternational marketEconomics and EconometricsLatin AmericansCointegrationFinancial economicsVariance decomposition of forecast errorsEconomicsStock marketSoutheast asianFinanceStock (geology)Vector autoregressionInternational Review of Economics & Finance
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Returns to Schooling in Spain: How Reliable are Instrumental Variable Estimates?

2002

This paper studies the ordinary least–squares (OLS) and instrumental variable (IV) estimates of the returns to schooling for male workers in Spain. OLS estimates are often biased due to the endogeneity of schooling, measurement errors or omitted variables. Proper IV estimates correct this bias. The reliability of family background, natural experiments (based on changes in the education system and season of birth) and the availability of a college in the province is checked using Spanish data. The results suggest that background and college availability are valid instruments and that the IV estimates of the returns to schooling are higher than OLS estimates. These results are in line with th…

Male workersObservational errorSeason of birthGeography Planning and DevelopmentInstrumental variableEconometricsEndogeneityReliability (statistics)DemographyMathematicsLabour
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Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency

2016

S-adenosylhomocysteine hydrolase (AHCY) deficiency is a rare autosomal recessive disorder in methionine metabolism caused by mutations in the AHCY gene. Main characteristics are psychomotor delay including delayed myelination and myopathy (hypotonia, absent tendon reflexes etc.) from birth, mostly associated with hypermethioninaemia, elevated serum creatine kinase levels and increased genome wide DNA methylation. The prime function of AHCY is to hydrolyse and efficiently remove S-adenosylhomocysteine, the by-product of transmethylation reactions and one of the most potent methyltransferase inhibitors. In this study, we set out to more specifically characterize DNA methylation changes in blo…

Male0301 basic medicineMethyltransferaselcsh:MedicineArtificial Gene Amplification and ExtensionGlycine N-MethyltransferaseBiochemistryPolymerase Chain Reactionlaw.inventionMethionine0302 clinical medicinelawAmino Acidslcsh:SciencePolymerase chain reactionGeneticsDNA methylationMammalian GenomicsMultidisciplinaryOrganic CompoundsGenomicsMethylationChromatinEnzymes3. Good healthNucleic acidsChemistryPhysical SciencesDNA methylationEpigeneticsFemaleDNA modificationChromatin modificationResearch ArticleChromosome biologyCell biologyAlu elementBiologyResearch and Analysis MethodsGenomic Imprinting03 medical and health sciencesAlu ElementsGeneticsSulfur Containing Amino AcidsHumansRepeated SequencesMolecular Biology TechniquesMolecular BiologyAmino Acid Metabolism Inborn ErrorsGeneBiology and life sciencesOrganic Chemistrylcsh:RChemical CompoundsInfant NewbornProteinsInfantDNAMethyltransferasesCreatineMolecular biologyLong Interspersed Nucleotide Elements030104 developmental biologyDifferentially methylated regionsAnimal GenomicsEnzymologyAHCY ; Hypermethylationlcsh:QGene expressionGenomic imprinting030217 neurology & neurosurgeryDevelopmental BiologyPLOS ONE
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Performance analysis of two immunochromatographic assays for the diagnosis of rotavirus infection

2017

Group A rotaviruses (RVAs) are the primary cause of acute gastroenteritis (AGE) in young children worldwide. Several commercial tests including latex agglutination, enzyme-linked assays (ELISA) and immunochromatographic tests (ICT) have been developed for the diagnosis of RVA infection. In the present study, the performance of two commercially available one-step chromatographic immunoassays, CerTest Rotavirus + Adenovirus (Biotec S.L, Zaragoza, Spain) and Vikia Rota-Adeno (bioMerieux SA, Lyon, France) were retrospectively evaluated using Real-time PCR as reference test. Re-testing by Real-time PCR of 2096 stool samples of children hospitalized with AGE previously screened by ICTs (1467 by C…

Male0301 basic medicineSettore MED/07 - Microbiologia E Microbiologia Clinica030106 microbiologymedicine.disease_causeSensitivity and SpecificityChromatography AffinityRotavirus InfectionsAstrovirusSentitivity03 medical and health sciencesPredictive Value of TestsVirologyRotavirusGenotypemedicineHumansImmunochromatographic AssaysDiagnostic ErrorsRetrospective Studiesbiologybusiness.industryInfant NewbornInfantRotavirubiology.organism_classificationVirologyGastroenteritisLatex fixation testRotavirus infectionItalyChild PreschoolSpecificityNorovirusFemaleImmunochromatographybusinessViral loadJournal of Virological Methods
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Quantitative Acylcarnitine Profiling in Peripheral Blood Mononuclear Cells Using In Vitro Loading With Palmitic and 2-Oxoadipic Acids: Biochemical Co…

2005

Organic acid (OAD) and fatty acid oxidation disorders (FAOD) are inborn errors of metabolism often presenting with life-threatening metabolic decompensation followed by (irreversible) organ failure, and even death during catabolic state. Most of these diseases are considered as treatable, and metabolic decompensations can be avoided by early diagnosis and start of therapy. Confirmation of suspected diagnosis currently relies on enzymatic and mutation analyses and in vitro loading of palmitic acid in human skin fibroblast cultures. Furthermore, in some cases potentially life-threatening in vivo loading or fasting tests are still performed. In this study, we established a standardized in vitr…

MaleAdipatesPalmitic AcidPeripheral blood mononuclear cellMass SpectrometryMonocytesPalmitic acidBlood cellchemistry.chemical_compoundIn vivoCarnitinemedicineHumansChildBeta oxidationGlutaric aciduriaInfantMetabolismVenous bloodmedicine.anatomical_structurechemistryBiochemistryChild PreschoolPediatrics Perinatology and Child HealthFemaleMetabolism Inborn ErrorsPediatric Research
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