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RESEARCH PRODUCT
The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency
Johannes M. GiesingerNeil K. AaronsonWei-chu ChieTeresa YoungAnna CostantiniIrma M. Verdonck-de LeeuwBernhard HolznerMogens GroenvoldMogens GroenvoldSusanne SingerThierry ConroyGalina VelikovaJuan Ignacio ArrarasMorten PetersenMadeleine Kingsubject
MESH: FatigueMaleEpidemiologyMESH: Aged 80 and over0302 clinical medicinePhysical functioningQuality of lifeNeoplasmsSurveys and QuestionnairesActivities of Daily LivingStatisticsMESH: NeoplasmsDiagnosis Computer-Assisted030212 general & internal medicineFatigueReliability (statistics)MathematicsMESH: AgedAged 80 and overMESH: Middle AgedMiddle Agedhumanities3. Good healthMESH: Reproducibility of ResultsLevel of measurementMESH: Young AdultData Interpretation Statistical030220 oncology & carcinogenesis/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleAdultmedicine.medical_specialtyAdolescentMean squared errorSensitivity and SpecificityYoung Adult03 medical and health sciencesSDG 3 - Good Health and Well-beingotorhinolaryngologic diseasesmedicineHumansMESH: Surveys and QuestionnairesAgedMESH: AdolescentMESH: HumansMESH: Activities of Daily LivingMESH: Diagnosis Computer-AssistedMESH: Quality of LifeReproducibility of ResultsMESH: Adultsocial sciencesMESH: MaleMESH: Sensitivity and SpecificitySample size determinationQuality of LifePhysical therapy[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieComputerized adaptive testingMESH: Data Interpretation StatisticalMESH: FemaleRelative validitydescription
Objectives: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is developing a computer-adaptive test (CAT) version of the EORTC Quality of Life Questionnaire (QLQ-C30). We evaluated the measurement properties of the CAT versions of physical functioning (PF) and fatigue (FA) and compared these with the corresponding QLQ-C30 scales. Study Design and Setting: Based on international samples of more than 1,000 cancer patients, we simulated CAT administration of varying numbers of items and compared the resulting scores with those based on all items in the respective item pools. Furthermore, the relative validity (RV) of CATs was compared with that of the QLQ-C30 scales using known groups validity. Results: For both dimensions, CATs of all lengths resulted in unbiased score estimates. CATs consisting of five or more items had reliability>0.90, correlated ≥0.97 with the full scale, and had root mean square error <0.25. The average RVs for these CATs ranged 1.02-1.33, indicating possible savings in sample size requirements of 3-42% using CAT. Conclusion: The CAT versions of PF and FA exhibited high levels of measurement precision and efficiency. The potential savings in sample size requirements using CATs compared with those using the original QLQ-C30 scales were typically 20% or more. © 2013 Elsevier Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-01 |