Search results for " FORMS"
showing 10 items of 199 documents
d-Alanyl-d-Alanine Carboxypeptidase in the Bacterial Form and L-Form of Proteus mirabilis
1975
Membranes of the bacterial form and the stable and unstable L-forms of Proteus mirabilis contain LD and DD-carboxypeptidase. The DD-carboxypeptidase is inhibited non-competitively by penicillin G. The enzyme of the bacterial form is highly penicillin-sensitive (Ki - 4 X 10(-9) M penicillin G). Inhibition is only partly reversible by treatment with penicillinase or by dialysis against buffer. In contrast, the DD-carboxypeptidase of the unstable L-form, grown in the presence of penicillin, is 175-fold less penicillin-sensitive (Ki = 7 X 10(7) M penicillin G). Inhibition is completely reversed by penicillinase or dialysis. After inhibition by penicillin and subsequent reactivation the penicill…
Spectrophotometric estimation of bicalutamide in tablets
2007
A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of bicalutamide in bulk and pharmaceutical dosage forms. Bicalutamide shows maximum absorbance at 272 nm with molar absorptivity of 2.3399×10(4) l/mol/cm. Beer's law was obeyed in the concentration range of 1.5-18 μg/ml. The limit of detection and limit of quantification were found to be 0.1 and 0.4 μg/ml, respectively. Results of analysis were validated statistically and by recovery studies.
Hydroxypropylmethylcellulose films for the ophthalmic delivery of diclofenac sodium
2012
Abstract Objectives The aim of this study was to prepare diclofenac/hydroxypropylmethylcellulose (HPMC) and diclofenac-loaded nanoparticles/HPMC films as potential systems for ocular delivery. Methods Two different concentration of the polymer were used: 1.5 and 2.0% w/v. Chitosan–hyaluronic acid nanoparticles were prepared by the ionotropic gelation technique. Nanoparticles were characterized by transmission electron microscopy, dynamic light scattering, drug encapsulation efficiency and rheological studies. In-vitro drug studies and corneal penetration release studies were carried out. Drug release mechanism was finally evaluated by fitting the Ritger and Peppas equation to data. In addit…
Generalized finite difference schemes with higher order Whitney forms
2021
Finite difference kind of schemes are popular in approximating wave propagation problems in finite dimensional spaces. While Yee’s original paper on the finite difference method is already from the sixties, mathematically there still remains questions which are not yet satisfactorily covered. In this paper, we address two issues of this kind. Firstly, in the literature Yee’s scheme is constructed separately for each particular type of wave problem. Here, we explicitly generalize the Yee scheme to a class of wave problems that covers at large physics field theories. For this we introduce Yee’s scheme for all problems of a class characterised on a Minkowski manifold by (i) a pair of first ord…
The impact of the COVID-19 pandemic on human rights of women and girls with disabilities
2021
El presente artículo aborda la situación de especial vulnerabilidad en la que se encuentran las mujeres y niñas con discapacidad, la cual se ha visto agravada en el contexto de la crisis provocada por la pandemia de Covid-19. En efecto, en la primera parte el autor toma nota del actual deterioro de los derechos humanos de las mujeres y niñas con discapacidad, lo cual constituye un desafío para evitar su marginación en términos de doble discriminación. Para afrontar dicho reto, en la segunda parte se pone el énfasis en el papel crucial de la Convención de Naciones Unidas sobre los derechos de las personas con discapacidad como estándar mínimo de protección. En este sentido, en la tercera par…
Unitary Groups Acting on Grassmannians Associated with a Quadratic Extension of Fields
2006
Let (V, H) be an anisotropic Hermitian space of finite dimension over the algebraic closure of a real closed field K. We determine the orbits of the group of isometries of (V, H) in the set of K-subspaces of V . Throughout the paper K denotes a real closed field and K its algebraic closure. Then it is well known (see, for example, [4, Chapter 2], [23]; see also [8]) that K = K(i) with i = √−1. Also we let (V,H) be an anisotropic Hermitian space (with respect to the involution underlying the quadratic field extension K/K) of finite dimension n over K. In this context we consider the natural action of the unitary group U = U(V,H) of isometries of (V,H) on the set Xd of all ddimensional K-subs…
Closedness and lower semicontinuity of positive sesquilinear forms
2009
The relationship between the notion of closedness, lower semicontinuity and completeness (of a quotient) of the domain of a positive sesquilinear form defined on a subspace of a topological vector space is investigated and sufficient conditions for their equivalence are given.
Nilpotent Lie algebras with 2-dimensional commutator ideals
2011
Abstract We classify all (finitely dimensional) nilpotent Lie k -algebras h with 2-dimensional commutator ideals h ′ , extending a known result to the case where h ′ is non-central and k is an arbitrary field. It turns out that, while the structure of h depends on the field k if h ′ is central, it is independent of k if h ′ is non-central and is uniquely determined by the dimension of h . In the case where k is algebraically or real closed, we also list all nilpotent Lie k -algebras h with 2-dimensional central commutator ideals h ′ and dim k h ⩽ 11 .
The Action of the Symplectic Group Associated with a Quadratic Extension of Fields
1999
Abstract Given a quadratic extension L/K of fields and a regular alternating space (V, f) of finite dimension over L, we classify K-subspaces of V which do not split into the orthogonal sum of two proper K-subspaces. This allows one to determine the orbits of the group SpL(V, f) in the set of K-subspaces of V.
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Codeine Phosphate
2014
The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be …