Search results for " Failure"
showing 10 items of 1828 documents
Duchenne Muscular Dystrophy (DMD): Should it be Considered a Systemic Disease?
2016
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease characterized by progressive skeletal muscle loss and development of respiratory failure due to involvement of respiratory muscles. Similar to human DMD, the mdx mouse model lacks dystrophin but is characterized by relatively mild muscle injury, allowing testing the effects of mild endurance exercise training on dystrophic skeletal muscle. We were interested to study the effects of exercise training on airway cells in trained mdx mice by applying the same protocol previously tested in Swiss mice. We found that mdx mice showed little airway inflammation associated with training, but developed increasing apoptosis of airway cells…
Molekulare Signalwege der aseptischen Endoprothesenlockerung (Molecular pathways in aseptic loosening of orthopaedic endoprosthesis)
2008
Operative joint replacement to treat disabling joint conditions secondary to degenerative and inflammatory arthritides has become one of the most efficacious and cost-effective procedures to relieve pain and restore joint function. However, prosthetic implants are not built to last forever and osteolysis and aseptic loosening has been associated with prosthetic arthroplasties since their introduction. The functional life of a synthetic joint is influenced by many factors including the material of the implant, operation procedures and the surgeon involved, as well as patient-related factors. Although promising developments have been achieved in this field, more than 10% of all implants still…
MINIMIZING INFLIXIMAB TOXICITY IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
2008
Abstract Background Infliximab is a widely used biological agent for the treatment of inflammatory bowel disease, and has a favorable risk/benefit ratio. Aim It is useful to know that patients treated with infliximab are exposed to developing adverse events that could be reduced with a prudent and a rational clinical approach and by optimizing the treatment protocol. Methods PubMed (including Epub) was searched in October 2006 and again in March 2007. Results The high immunogenic potential of infliximab determines the antibodies that inhibit the effect of infliximab and the appearance of subsequent acute and delayed infusion reactions. Infliximab has an immunomodulatory effect, thus increas…
Coronary Stent Strut Fractures: Classification, Prevalence and Clinical Associations
2021
Introduction. The frequency, characteristics and clinical implications of Strut fractures (SFs) remain incompletely understood. Methods and results. A total of 185 (160 patients) newer-generation drug-eluting stents (DES) were imaged. SFs were found in 21 DES (11.4%) and were classified in four patterns: one single stacked strut (41%)
Clinical utilization of natriuretic peptide determination in acute congestive heart failure
2010
Novel Translational Read-through–Inducing Drugs as a Therapeutic Option for Shwachman-Diamond Syndrome
2022
Shwachman-Diamond syndrome (SDS) is one of the most commonly inherited bone marrow failure syndromes (IBMFS). In SDS, bone marrow is hypocellular, with marked neutropenia. Moreover, SDS patients have a high risk of developing myelodysplastic syndrome (MDS), which in turn increases the risk of acute myeloid leukemia (AML) from an early age. Most SDS patients are heterozygous for the c.183-184TA>CT (K62X) SBDS nonsense mutation. Fortunately, a plethora of translational read-through inducing drugs (TRIDs) have been developed and tested for several rare inherited diseases due to nonsense mutations so far. The authors previously demonstrated that ataluren (PTC124) can restore full-length SBDS…
Nawracające częstoskurcze komorowe w przebiegu zawału NSTEMI utrzymujące się pomimo rewaskularyzacji i zastosowanej farmakoterapii
2018
Przedstawiamy pacjenta z nawracającymi niestabilnymi hemodynamicznie częstoskurczami komorowymi w okresie zawału mięśnia sercowego bez uniesienia odcinka ST powikłanego niewydolnością krążenia. Komorowe zaburzenia rytmu utrzymywały się pomimo wdrożonej farmakoterapii przeciwniewydolnościowej, zastosowania amiodaronu i przeprowadzonej rewaskularyzacji. W związku z tym zastosowano niestandardową farmakoterapię oraz metody zabiegowe takie jak ablacja endowaskularna i implantacja kardiowertera-defibrylatora.
Niewydolność serca - problem medyczny, ekonomiczny i społeczny
2019
Pierwsze wzmianki o chorobie, którą dzisiaj określamy jako niewydolność serca, pochodzą z czasów antycznych. Epidemiologia objawowej niewydolności serca jest dobrze poznana, szczególnie w Europie. Na naszym kontynencie niewydolność serca występuje u około 2% dorosłej populacji. W artykule przedstawiono: defnicję, epidemiologię i rokowanie chorych z niewydolnością serca. Opracowanie charakteryzuje aktualne metody farmakoterapii i leczenia interwencyjnego. Ważnym elementem postępowania u chorych z niewydolnością serca jest rehabilitacja medyczna i przestrzeganie zasad proflaktyki chorób sercowo-naczyniowych zalecanych przez Europejskie Towarzystwo Kardiologiczne. Artykuł porusza również temat…
Nitric oxide metabolites in chronic renal failure in conservative and in haemodialysis treatment.
2008
Sleep-disordered breathing in the elderly
2009
Purpose: The prevalence of sleep-disordered breathing (SDB) increases with aging. SDB is a risk of hypertension, and both might lead to cognitive decline. However, the role of SDB and hypertension on the pathogenesis of age-related cognitive decline remains unclear. We examined the effects of these two diseases on cognitive function in elderly adults.