Search results for " Farm"

Hyaluronan-coated polybenzofulvene brushes as biomimetic materials

2016

Hyaluronic acid (HA) forms pericellular coats in many cell types that are involved in the early stages of cell adhesion by interacting with the CD44 receptor. Based on the largely recognized overexpression of the CD44 receptor in tumor tissues, a polybenzofulvene molecular brush has been enveloped into hyaluronan shells to obtain a tri-component polymer brush (TCPB) composed of intrinsically fluorescent backbones bearing nona(ethylene glycol) arms terminated with low molecular weight HA macromolecules. The nanoaggregates obtained in TCPB water dispersions were characterized on the basis of dimensions, zeta potential, and in vitro cell toxicity. This biomimetic multifunctional material beari…

Hospitalization and mortality among the elderly exposed to polytherapy and at risk of adverse drug reactions

2017

The increase in comorbidities due to an aging population determines a marked increase in the use of drugs (polypharmacy), which in turn carries a high risk of drug-drug interactions. This Paper will analyze the relationship between exposure to adverse drug interactions, and hospitalization and mortality in a cohort of elderly patients, living in a local Health Unit in Palermo, Italy. These patients were exposed to drugs whose concurrent use is contraindicated during the period 1.1.2014 - 30.12.2014. After a description of the most common drugs involved in adverse reactions, an evaluation of the extent of hospitalization and mortality will be performed. The results will demonstrate that ther…

Invasive alien species – potential cheap resources of plant substances for medicinal use

2018

Some alien species demonstrate rather invasive behaviour. They have high tolerance of various habitat conditions and potent propagation ability. They not only over-compete the local vegetation but suppress the seed development of the native plants. In the newly invaded habitats they might not have suitable herbivores to control their populations. The only effective enemy might be Homo sapiens. Humans are known with their destructive power once an object has become significant for industrial utilization. The aim of this study is to review research data and reveal the potential of Ambrosia artemisiifolia L., Erigeron canadensis L., Xanthium strumarium L. and Dittrichia graveolens (L.) W. Greu…

Precison Farming: l’Agricoltura 4.0

2016

Relazione presentata a Bologna il 9 novembre, presso il palazzo dei Congressi dell’Ente Fiere di Bologna, in occasione della 42esima manifestazione dell’EIMA, il Corso per Giornalisti dell’UNAGA dal titolo: ” Ruolo e responsabilità del giornalista nel promuovere la lotta allo spreco attraverso l’utilizzo delle nuove tecnologie”

Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated ad…

2002

A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male rats exposed to forced swim test (FST), acoustic startle reflex (ASR) and Vogel test (VT). The effects on motor activity were evaluated in the open field and in the Skinner box…

Intervención farmacéutica sobre la prescripción inapropiada del paciente mayor polimedicado en diferentes niveles asistenciales

2017

A medida que aumenta la esperanza de vida de la población, las personas viven más tiempo con discapacidad y múltiples morbilidades. Esta situación tiene importante repercusión en los sistemas de salud a nivel mundial por su relación directa con el incremento de la cronicidad, pluripatología y polimedicación. Está demostrado que a mayor número de fármacos prescritos, aunque éstos fuesen apropiados, mayor es la posibilidad de que haya alguno no necesario y de que aparezcan efectos adversos prevenibles. La polimedicación es apropiada, cuando el paciente toma muchos fármacos, pero todos ellos tienen indicación clínica. Y polimedicación es inapropiada, cuando se toman más medicamentos de los clí…

Analisi statistica dei casi di intossicazione rilevati al Pronto Soccorso dell'Ospedale dei Bambini G. di Cristina di Palermo nel periodo 2011-2015

2015

Lo Studio affronta l'incidenza dei casi di intossicazione riscontrati, nel periodo 2011- 2015 , presso l'Ospedale dei Bambini G. di Cristina di Palermo. Lo scopo è di identificare gli agenti eziologici più frequenti e la relativa incidenza nel periodo preso in esame.

New indole and 7-azaindole derivatives as protein kinase inhibitors

2023

Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH comp…

2018

Introduction There are few effective therapies for malignant pleural mesothelioma (MPM), which remains one of the most lethal cancers. We previously demonstrated that low expression of the PCFT transporter, both at mRNA and protein levels, is associated with shorter survival of MPM patients treated with pemetrexed (Giovannetti et al., 2017). Since hypoxia has also been associated to antifolate-resistance (Raz et al, 2014), this study was aimed at elucidating key factors in pemetrexed resistance and hypoxia that may contribute to the rational development of novel therapeutic interventions against mesothelioma. Methods The levels of PCFT and of the hypoxia marker carbonic anhydrase-IX were de…

Muchomor czerwony (Amanita muscaria) jako obiecujące źródło ergosterolu

2012

Ergosterol (prowitamina D) jest jednym z głównych składników błon komórkowych grzybów. Ma on obiecujące właściwości immunostymulujące i przeciwrakowe. Muchomor czerwony stanowi bogate źródło ergosterolu, który po ekstrakcji n-heksanem lub octanem etylu łatwo jest otrzymać w formie krystalicznej. Fly agaric was extd. with n-hexane or EtOH optionally under microwave aid to recover ergosta-5,7,22-trien-3β- ol and other steroids. The highest yield was achieved by extn. of the gills, EtOAc was more efficient than n-hexane as a solvent. Ergosterol (ergosta-5,7,22-trien-3β-ol) jest biologicznym prekursorem (prowitaminą) witaminy D2. Jest to główny steryd błon komórkowych grzybów. Ponieważ rzadko w…