Search results for " Farm"
showing 10 items of 2009 documents
Estudio cualitativo sobre las barreras y los factores facilitadores en la demanda de los Servicios Profesionales Farmacéuticos Asistenciales en las f…
2023
INTRODUCCIÓN Según estudios recientes, los Servicios Profesionales Farmacéuticos Asistenciales (SPFA) demostraron sus beneficios en la calidad de vida de pacientes y sistemas de salud. Los SPFA son actividades sanitarias prestadas desde la farmacia comunitaria (FC), para la prevención de enfermedades y la mejora de la salud mediante la optimización del uso y del resultado de los tratamientos. Sin embargo, en España existe un bajo porcentaje de farmacias comunitarias que ofrecen SPFA, a excepción de la dispensación, indicación farmacéutica, medida de parámetros clínicos, la educación/ información sanitaria y la formulación magistral ya arraigados en la profesión desde hace tiempo. OBJETIVO A…
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp. siculum
2012
WOS: 000306752700042
Epigenetic regulation of sex differences in susceptibility to stress
2017
Under current diagnostics depression and stress related mood disorders have a higher occurrence in women than men. Little is known of the biological mechanisms contributing to these sex differences and how they may impact potential new therapeutics. Here we examine how DNA methylation contributes to sex specific stress vulnerability in adult animals. Mice of both sexes were exposed to variable stress and given a behavioral test battery to examine stress sensitivity. Female mice expressed depressionassociated behavior across all tests stress exposure whereas males were behaviorally resilient. Markers of pre and post-synaptic plasticity and spine morphology were examined using a combination o…
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery
2015
A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…
Zakorzenienie gospodarstw rolnych w lokalnych (regionalnych) systemach biobiznesu – uwarunkowania instytucjonalne w województwie opolskim
2016
Celem opracowania jest wskazanie na rolę instytucji w kreowaniu lokalnych (regionalnych) biobiznesów. Lokalne biobiznesy opierają się na unikatowym wykorzystaniu zarówno standardowych, jak i specyficznych zasobów terytoriów, w których są zakładane. Analizę przeprowadzono z wykorzystaniem trzech wymiarów transformacji europejskiego modelu rolnictwa: regulacji środowiskowych, dyfuzji wiedzy i informacji oraz powiązań międzyorganizacyjnych i społecznych. Na podstawie przeprowadzonych badań ankietowych zidentyfikowano stopień zakorzenienia instytucji zarządzających powstaniem biogospodarki w sieciach społecznych użytkowników towarowych gospodarstw rolnych w województwie opolskim. Praca ma chara…
UPTAKE OF SILICA COVERED QUANTUM DOTS ON LIVING CELLS: LONG TERM VITALITY AND MORPHOLOGY STUDY ON HYALURONIC ACID BIOMATERIALS
2015
In this work we prepared colloidal CdSe-CdS core-shell nanocrystal emitting @625 nm and, by a micro-emulsion procedure of water in oil inverse micelle, we encapsulated a single dot inside each silica sphere. In this way the nanoparticles became biocompatible, are simply to prepare and could be used also in a water based environment. Moreover, the silica shield is transparent to the wavelengths of interest.
DELIVERY DI SOSTANZE ATTIVE DEL SISTEMA NERVOSO CENTRALE MEDIANTE PROFARMACI O SISTEMI PARTICELLARI
2012
Analysis of the molecular mechanisms that mediate the therapeutic actions of glucocorticoids in skin
2017
Tesis doctoral 189 páginas, 53 figuras, 1 tabla como material suplementario