Search results for " Follow-Up Studies"

showing 10 items of 116 documents

Does access to care play a role in liver cancer survival? The ten-year (2006–2015) experience from a population-based cancer registry in Southern Ita…

2021

Abstract Background Hepatocellular carcinoma (HCC) is the most frequent primary invasive cancer of the liver. During the last decade, the epidemiology of HCC has been continuously changing in developed countries, due to more effective primary prevention and to successful treatment of virus-related liver diseases. The study aims to examine survival by level of access to care in patients with HCC, for all patients combined and by age. Methods We included 2018 adult patients (15–99 years) diagnosed with a primary liver tumour, registered in the Palermo Province Cancer Registry during 2006–2015, and followed-up to 30 October 2019. We obtained a proxy measure of access to care by linking each re…

AdultMaleCancer Researchmedicine.medical_specialtyCarcinoma HepatocellularAdolescentContext (language use)access to care cancer registries liver cancer public health survival Adolescent AdultAge Distribution Aged Aged 80 and over Carcinoma Hepatocellular Decision Making Organizational Decision Support Techniques Female Follow-Up Studies Health Services Accessibility Health Services Needs and Demand Humans Italy Liver Neoplasms Male Middle Aged Registries Survival Analysis Young AdultSettore MED/42 - Igiene Generale E Applicatalcsh:RC254-282survivalHealth Services AccessibilityDecision Support Techniquesliver cancerYoung AdultAge DistributionInternal medicineHealth careEpidemiologyGeneticsmedicineHumansRegistriesDecision Making OrganizationalAgedAged 80 and overaccess to careHealth Services Needs and Demandbusiness.industryPublic healthLiver Neoplasmspublic healthMiddle Agedlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseSurvival AnalysisCancer registryItalyOncologycancer registriesHepatocellular carcinomaAmbulatoryFemaleLiver cancerbusinessFollow-Up StudiesResearch ArticleBMC Cancer
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Zonisamide in children and young adults with refractory epilepsy: an open label, multicenter Italian study

2009

Summary Purpose To report on the first multicenter Italian experience with zonisamide as an add-on drug for refractory generalised or partial epilepsy in children, adolescents and young adults. Methods The patients were enrolled in a prospective, add-on, open-label treatment study from eight Italian centres for children and adolescent epilepsy care. Eighty-two young patients (45 males, 37 females), aged between 3 and 34 years (mean 13.1 years), all affected by partial (47) or generalised (35) refractory epilepsy, were enrolled in the study. ZNS was added to the baseline therapy at a starting dose of 1 mg/kg/day twice daily. This dose was increased by 2 mg/kg every 1–2 weeks over a period of…

AdultMalePediatricsmedicine.medical_specialtyAdolescentmedicine.medical_treatmentAntiepileptic drugsZonisamideIrritabilityStatistics NonparametricEpilepsyYoung AdultRefractorymedicineHumansNonparametricYoung adultAdverse effectPreschoolChildNeurologic ExaminationEpilepsybusiness.industryStatisticsElectroencephalographyDrug ToleranceIsoxazolesmedicine.diseaseMagnetic Resonance ImagingSettore MED/39 - Neuropsichiatria InfantileEpilepsy; Zonisamide; Pediatric epilepsy; Antiepileptic drugsAnticonvulsantTolerabilityNeurologyItalyZonisamideChild PreschoolAnticonvulsantsFemaleNeurology (clinical)medicine.symptombusinessPediatric epilepsyAntiepileptic drugs; Epilepsy; Pediatric epilepsy; Zonisamide; Adolescent; Adult; Anticonvulsants; Child; Child Preschool; Drug Tolerance; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Isoxazoles; Italy; Magnetic Resonance Imaging; Male; Neurologic Examination; Statistics Nonparametric; Young Adult; Neurology; Neurology (clinical)medicine.drugFollow-Up Studies
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Clinical analysis following lumbar interspinous devices implant: where we are and where we go

2014

Objectives:We present our experience with patients treated with interspinous devices who are affected by neurogenic intermittent claudication (NIC) or lumbar disc herniation (LDH) where the interspinous system has been inserted following microdiscectomy.Study design:Retrospective study.Methods:This study included patients (n=100) with NIC secondary to lumbar spinal stenosis (group 1), and patients (n=100) with LDH (group 2) in whom the interspinous device has been implanted following radicular decompression in a period spanning 6 years. The latter have been compared with a homogenous group of patients (n=100) where no interspinous system has been implanted following microdiscectomy (group 3…

AdultMaleReoperationMicrosurgerymedicine.medical_specialtyTime FactorsVisual analogue scaleDecompressionlumbar interspinous devicesAdult Prostheses and Implants Aged Decompression Surgical Disability Evaluation Female Follow-Up Studies Intermittent Claudication Intervertebral Disc Displacement Humans Lumbar Vertebrae Microsurgery Minimally Invasive Surgical Procedures Middle Aged Male Retrospective Studies Pain Measurement Patient Satisfaction Surveys and Questionnaires Reoperation Recurrence Treatment Outcome Spinal StenosisDisability EvaluationSpinal StenosisLumbarRecurrenceSurveys and QuestionnairesmedicineHumansMinimally Invasive Surgical ProceduresAgedPain MeasurementRetrospective StudiesLumbar VertebraeSettore MED/27 - Neurochirurgiabusiness.industryLumbar spinal stenosisProstheses and ImplantsGeneral MedicineIntermittent ClaudicationMiddle AgedDecompression Surgicalmedicine.diseaseIntermittent claudicationOswestry Disability IndexSurgeryTreatment OutcomeNeurologyPatient SatisfactionFemaleNeurology (clinical)Implantmedicine.symptombusinessClaudicationIntervertebral Disc DisplacementFollow-Up StudiesSpinal Cord
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Advancement flap in the management of chronic anal fissure: A prospective study

2012

Lateral internal sphincterotomy is the surgical treatment of choice of chronic anal fissure after failure of conservative measures. Several randomized trials identified an overall risk of incontinence of 10 % mostly for flatus. Fissurectomy is the most commonly used procedure to preserve the integrity of the anal sphincters. However, a possible complication is keyhole defect that may lead to faecal soiling. In this study, chronic anal fissure (CAF) was treated by fissurectomy and anal advancement flap to preserve the anatomo-functional integrity of sphincters and to reduce healing time and the risk of anal stenosis. In patients with hypertonia, surgical treatment was combined with chemical …

AdultMalemedicine.medical_specialtyAdolescentmedicine.medical_treatmentInjections IntramuscularSurgical FlapsFissurectomyFollow-Up StudieInternal anal sphincterAnal stenosismedicineDeformityHumansReconstructive Surgical ProcedureProspective StudiesKeyhole defectBotulinum Toxins Type ADigestive System Surgical ProceduresAdvancement flapAgedNeuromuscular Agentbusiness.industryUrinary retentionDigestive System Surgical ProcedureRecovery of FunctionPlastic Surgery ProceduresMiddle AgedSurgerySurgical FlapProspective StudieSettore MED/18 - Chirurgia GeneraleTreatment OutcomeNeuromuscular AgentsAnesthesiaChronic DiseaseDefecationHypertoniaFemaleSurgeryFissure in AnoAdvancement flap; Chronic anal fissure; Fissurectomy; Adolescent; Adult; Aged; Botulinum Toxins Type A; Chronic Disease; Digestive System Surgical Procedures; Female; Fissure in Ano; Follow-Up Studies; Humans; Injections Intramuscular; Male; Middle Aged; Neuromuscular Agents; Prospective Studies; Reconstructive Surgical Procedures; Recovery of Function; Treatment Outcome; Surgical Flaps; Surgerymedicine.symptombusinessLateral internal sphincterotomyChronic anal fissureFollow-Up StudiesHuman
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Acute inflammatory response in the subcutaneous versus periprosthethic space after incisional hernia repair: an original article.

2014

BACKGROUND: The acute inflammatory response following mesh implantation has been often evaluated in vitro and in animal models. The aim of this study was to evaluate the acute inflammatory response near the prosthesis in human by analysing some inflammatory indicators.METHODS: We used a cohort of twelve male patients affected by midline incisional hernia, who were admitted for surgical mesh repair. A suction drain was placed between the mesh and rectal muscles whereas, the other one was placed between the subcutaneous tissue and the oblique external sheath. The acute inflammatory response was analyzed by measuring the production of interleukin [IL]-1, IL-10, IL-1ra, C-Reactive Protein (CRP)…

AdultMalemedicine.medical_specialtyIncisional herniamedicine.medical_treatmentAcute Disease; Adult; Biomarkers; C-Reactive Protein; Cytokines; Follow-Up Studies; Hernia Ventral; Herniorrhaphy; Humans; Inflammation; Male; Middle Aged; Surgical Mesh; Postoperative Complications; Medicine (all)InflammationProsthesisProsthesisFollow-Up StudiePostoperative ComplicationsDrain fluidmedicineHumansCytokineHerniorrhaphyInflammationbiologybusiness.industryMedicine (all)C-reactive proteinAlbuminInflammatory responseGeneral MedicineBiomarkerMiddle AgedSurgical Meshmedicine.diseaseHernia repairHernia VentralSurgerySettore MED/18 - Chirurgia GeneraleSurgical meshmedicine.anatomical_structureC-Reactive ProteinAcute Diseasebiology.proteinCytokinesHernia repairSurgeryPostoperative Complicationmedicine.symptombusinessBiomarkersSubcutaneous tissueHumanFollow-Up StudiesResearch ArticleBMC surgery
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The relationship between the dietary inflammatory index (DII®) and incident depressive symptoms: A longitudinal cohort study

2018

Abstract Background Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII®), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults. Methods This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire. Center for Epidemiological Studies Depression-20 scale was used to define depressive symptoms. The relationship between…

AdultMalemedicine.medical_specialtyLongitudinal studyNeuroimmunologyOld ageDiet SurveysCohort Studies03 medical and health sciences0302 clinical medicineInternal medicineEpidemiologyHumansMedicineLongitudinal Studies030212 general & internal medicineHealth behaviorDepression (differential diagnoses)AgedProportional Hazards ModelsInflammationPsychiatric Status Rating ScalesDepressionbusiness.industryIncidenceIncidence (epidemiology)Hazard ratioConfoundingDepression Health behavior Neuroimmunology Old ageMiddle AgedDietPsychiatry and Mental healthClinical PsychologyQuartileCohortFemalebusiness030217 neurology & neurosurgeryDepression; Health behavior; Neuroimmunology; Old age; Adult; Aged; Cohort Studies; Depression; Diet; Diet Surveys; Female; Follow-Up Studies; Humans; Incidence; Inflammation; Longitudinal Studies; Male; Middle Aged; Proportional Hazards Models; Psychiatric Status Rating ScalesFollow-Up StudiesJournal of Affective Disorders
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Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study

2016

Background and Aims: Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer in IBD. The role of immunomodulators vs clinical characteristics of IBD as risk factors for cancer was also investigated. Materials and Methods: From January 2012 to December 2014, each IBD patient with incident cancer was matched with two IBD patients without cancer for: IBD type, gender, and age. Risk factors were assessed by multivariate regression analysis. Results: IBD patients considered numbered 44619: 21953 Crohn’s disease \[CD], 22666 ulcerative colitis [UC]. Cancer occurred in 174 patients…

AdultMalemedicine.medical_specialtyPancolitisAdolescentColorectal cancerphenotypeSettore MED/12 - GASTROENTEROLOGIAcancer riskInflammatory bowel disease; cancer risk; phenotype; Adolescent; Adult; Aged; Aged 80 and over; Case-Control Studies; Female; Follow-Up Studies; Humans; Immunologic Factors; Incidence; Inflammatory Bowel Diseases; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasms; Prospective Studies; Risk Factors; Young Adult; PhenotypeGastroenterologyInflammatory bowel diseaseInflammatory bowel disease03 medical and health sciencesYoung Adult0302 clinical medicineRisk FactorsInternal medicineNeoplasms80 and overmedicineHumansImmunologic FactorsProspective StudiesRisk factorProspective cohort studyAgedAged 80 and overbusiness.industryIncidenceSettore MED/09 - MEDICINA INTERNAGastroenterologyCancerGeneral MedicineMiddle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisLogistic Models030220 oncology & carcinogenesisCase-Control StudiesNested case-control studyMultivariate Analysis030211 gastroenterology & hepatologyFemalemedicine.symptombusinessInflammatory bowel disease; cancer risk; phenotypeFollow-Up Studies
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Influence of Intraperitoneal Dissemination Assessed by Laparoscopy on Prognosis of Advanced Ovarian Cancer: An Exploratory Analysis of a Single-Insti…

2014

Purpose: The aim of this study was to investigate whether preoperative laparoscopic evaluation of the dissemination of disease may have an independent impact on survival in advanced epithelial ovarian cancer (AEOC).Methods: All AEOC women were submitted to staging laparoscopy before receiving primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT). All study women received a laparoscopic score (predictive index value [PIV]) and were stratified into three groups based on volume of disease: high tumor load (HTL) for PIV ≥8, intermediate tumor load (ITL) for PIV equal to 6 and 4, and low tumor load (LTL) for PIV 1 cm in 15 cases (9.1 %). When stratifying the whole population accordi…

AdultOncologymedicine.medical_specialtyNeoplasm ResidualAdult; Aged; Aged; 80 and over; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Laparoscopy; Middle Aged; Neoplasm Staging; Neoplasm; Residual; Ovarian Neoplasms; Peritoneal Neoplasms; Prognosis; Retrospective Studies; Survival Rate; Tumor BurdenPopulationlaparoscopySurgical oncologyInternal medicineHumansMedicineeducationLaparoscopySurvival ratePeritoneal NeoplasmsAgedNeoplasm StagingRetrospective StudiesAged 80 and overOvarian Neoplasmseducation.field_of_studymedicine.diagnostic_testPerformance statusbusiness.industryMedicine (all)Retrospective cohort studyMiddle AgedPrognosismedicine.diseaseDebulkingCombined Modality TherapyTumor BurdenSurvival Rateovarian cancerSettore MED/40 - GINECOLOGIA E OSTETRICIAOncologyFemaleSurgerybusinessOvarian cancerFollow-Up StudiesAnnals of Surgical Oncology
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Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St G…

2009

Background: Defining risk categories in breast cancer is of considerable clinical significance. We have developed a novel risk classification algorithm and compared its prognostic utility to the Web-based tool Adjuvant! and to the St Gallen risk classification. Patients and methods: After a median follow-up of 10 years, we retrospectively analyzed 410 consecutive node-negative breast cancer patients who had not received adjuvant systemic therapy. High risk was defined by any of the following criteria: (i) age 2 cm. All patients were also characterized using Adjuvant! and the St Gallen 2007 risk categories. We analyzed disease-free survival (DFS) and overall survival (OS). Results: The Node-…

AdultTime FactorsBreast NeoplasmsKaplan-Meier EstimateRisk AssessmentSensitivity and SpecificityDisease-Free SurvivalBreast cancerBreast cancer 3Predictive Value of TestsMedicineHumansLongitudinal StudiesProspective StudiesRisk factorAgedNeoplasm StagingRetrospective StudiesAged 80 and overNeovascularization Pathologicbusiness.industryHazard ratioCancerRetrospective cohort studyHematologyGenes erbB-2Middle Agedmedicine.diseasePrognosisImmunohistochemistrySurvival AnalysisTreatment OutcomeOncologyAdult; Aged; Aged 80 and over; Algorithms; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Breast Neoplasms/radiotherapy; Breast Neoplasms/surgery; Disease-Free Survival; Female; Follow-Up Studies; Genes erbB-2; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Longitudinal Studies; Middle Aged; Multivariate Analysis; Neoplasm Staging; Neovascularization Pathologic; Predictive Value of Tests; Prognosis; Prospective Studies; Receptors Progesterone/analysis; Regression Analysis; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Time Factors; Treatment OutcomeMultivariate AnalysisRegression AnalysisFemaleBreast diseasebusinessRisk assessmentReceptors ProgesteroneAlgorithmAlgorithmsFollow-Up Studies
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Transition Care in Anorexia Nervosa Through Guidance Online from Peer and Carer Expertise (TRIANGLE): Study Protocol for a Randomised Controlled Trial

2017

TRIANGLE is a multicentre trial investigating whether the addition of a novel intervention for patients and carers (ECHOMANTRA) to treatment as usual (TAU) improves outcomes for people with anorexia nervosa (AN). ECHOMANTRA is based on the cognitive interpersonal model of AN and includes assessments, workbooks, videos, online groups and joint Skype sessions for patients and carers. People receiving intensive hospital treatment (N = 380) will be randomised to TAU or TAU plus ECHOMANTRA. Participants will be assessed over an 18-month period following randomisation. The primary outcome is patient psychological well-being at 12 months postrandomisation. Secondary outcomes include (i) patient's …

Adultanorexia nervosa carer skills guided self-help skills sharing Adult Anorexia Nervosa Caregivers Follow-Up Studies Humans Internet Peer Group Quality of Life Research Design Transitional Care Treatment OutcomeInternetanorexia nervosa; carer skills; eating disorders; guided self-help; skills sharingTransitional Careeating disorderscarer skillsPeer Groupguided self-helpanorexia nervosaHTreatment OutcomeCaregiversResearch DesignSettore M-PSI/08 - Psicologia ClinicaQuality of LifeHumansskills sharingFollow-Up Studies
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