Search results for " Force"
showing 10 items of 2250 documents
Why ruminating ungulates chew sloppily: Biomechanics discern a phylogenetic pattern.
2019
Altres ajuts: "Beatriu de Pinos" 2014 - BP-A 00048 There is considerable debate regarding whether mandibular morphology in ungulates primarily reflects phylogenetic affinities or adaptation to specific diet. In an effort to help resolve this debate, we use three-dimensional finite element analysis (FEA) to assess the biomechanical performance of mandibles in eleven ungulate taxa with well-established but distinct dietary preferences. We found notable differences in the magnitude and the distribution of von Mises stress between Artiodactyla and Perissodactyla, with the latter displaying lower overall stress values. Additionally, within the order Artiodactyla the suborders Ruminantia and Tylo…
The way wear goes: phytolith-based wear on the dentine–enamel system in guinea pigs (Cavia porcellus)
2019
The effect of phytoliths on tooth wear and function has been contested in studies of animal–plant interactions. For herbivores whose occlusal chewing surface consists of enamel ridges and dentine tissue, the phytoliths might particularly erode the softer dentine, exposing the enamel ridges to different occlusal forces and thus contributing to enamel wear. To test this hypothesis, we fed guinea pigs (Cavia porcellus; n = 36 in six groups) for threeweeks exclusively on dry or fresh forage of low(lucerne), moderate (fresh timothy grass) or very high (bamboo leaves) silica content representing corresponding levels of phytoliths. We quantified the effect of these treatments with measuremen…
Modular Wear Facet Nomenclature for mammalian post-canine dentitions
2017
Dental wear facets on the occlusal surface of premolars and molars are traces of their main function, the mastication and therefore reflect masticatory movements and also paramasticatory (i.e. non-dietary use of teeth) behavior. Here we present the Modular Wear Facet Nomenclature applicable to most mammalian dentitions. Topographic positions of wear facets in relation to the major cusps and crests of the teeth are used to designate the areas of the occlusal surface the facets occupy (e.g. their mesial, distal, lingual, or buccal position). Previous published systems for labeling wear facets have been inconsistent with each other. Therefore, we provide a synoptic review of the most widely-us…
Rocking of rigid block on nonlinear flexible foundation
2017
Abstract The two prime models used currently to describe rocking of rigid bodies, the Housner’s model and the Winkler foundation model, can capture some of the salient features of the physics of this important problem. These two models involve either null or linear interaction between the block and the foundation. Hopefully, some additional aspects of the problem can be captured by an enhanced nonlinear model for the base-foundation interaction. In this regard, what it is adopted in this paper is the Hunt and Crossley’s nonlinear impact force model in which the impact/contact force is represented by springs in parallel with nonlinear dampers. In this regard, a proper mathematical formulatio…
On break-away forces in actuated motion systems with nonlinear friction
2017
The phenomenon of so-called break-away forces, as maximal actuation forces at which a sticking system begins to slide and thus passes over to a steady (macro) motion, is well known from engineering practice but still less understood in its cause-effect relationship. This note analyzes the break-away behavior of systems with nonlinear friction, which is analytically well-described by combining the Coulomb friction law with rate-independent presliding transitions and, when necessary, Stribeck effect of the velocity-weakening steady-state curve. The break-away conditions are harmonized with analytic form of the system description and shown to be in accord with a relationship between the varyin…
Comparison of electropolishing behaviours of TSC, ALM and cast 316L stainless steel in H 3 PO 4 /H 2 SO 4
2017
Abstract In recent decades, new manufacturing processes have been developed such as Thermal Spray Coating (TSC) and Additive Layer Manufacturing (ALM), which reduce or avoid machining of parts with complex geometries. This study aims to develop an Electropolishing (EP) process for TSC and ALM 316L Stainless Steel (SS). EP is an anodic dissolution process currently used in industry to reduce surface roughness and obtain a bright and smooth finish. The EP mechanism was studied, in a mixture of H3PO4 and H2SO4, for TSC, ALM and “cast” SS in order to determine the best conditions (time, temperature, potential). Special attention was paid to surface characterization by combining several techniqu…
Onset of cohesion in cement paste
2004
It is generally agreed that the cohesion of cement paste occurs through the formation of a network of nanoparticles of a calcium-silicate-hydrate ("C-S-H"). However, the mechanism by which these particles develop this cohesion has not been established. Here we propose a dielectric continuum model which includes all ionic interactions within a dispersion of C-S-H particles. It takes into account all co-ions and counterions explicitly (with pure Coulomb interactions between ions and between ions and the surfaces) and makes no further assumptions concerning their hydration or their interactions with the surface sites. At high surface charge densities, the model shows that the surface charge of…
Acoustic radiation force impulse point shear wave elastography of the liver and spleen in patients with Gaucher disease type 1: Correlations with cli…
2020
To evaluate the feasibility of acoustic radiation force impulse point shear wave elastography (ARFI-pSWE) of the liver and spleen in patients with Gaucher disease type 1 (GD1), and to assess correlations between organ stiffness and clinico-radiologic data, particularly the GD1 Severity Scoring System (GD-DS3).We retrospectively evaluated the results of ARFI-pSWE as measures of liver and spleen stiffness in 57 patients with GD1. The feasibility of the method was assessed. Correlations between elastography data and clinical data related to the metabolic syndrome, laboratory tests, and GD1-related clinico-radiologic data (bone marrow burden score, GD-DS3) were assessed.ARFI-pSWE provided relia…
Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics an…
2020
Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the 'German Cancer Aid' (Deutsche Krebshilfe [DKH]) a task force 'Molecular Diagnostics and Therapy' was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified …
Microtubule disruption changes endothelial cell mechanics and adhesion
2019
AbstractThe interest in studying the mechanical and adhesive properties of cells has increased in recent years. The cytoskeleton is known to play a key role in cell mechanics. However, the role of the microtubules in shaping cell mechanics is not yet well understood. We have employed Atomic Force Microscopy (AFM) together with confocal fluorescence microscopy to determine the role of microtubules in cytomechanics of Human Umbilical Vein Endothelial Cells (HUVECs). Additionally, the time variation of the adhesion between tip and cell surface was studied. The disruption of microtubules by exposing the cells to two colchicine concentrations was monitored as a function of time. Already, after 3…