Search results for " Formation"
showing 10 items of 1920 documents
Cyclophosphamide-Induced Morphological Changes in Dental Root Development of ICR Mice.
2015
Background Survivors of childhood cancer are at risk of late dental development. Cyclophosphamide is one of the most commonly used chemotherapeutic agents against cancer in children. The aim of this study was to investigate the effects of cyclophosphamide on root formation in the molars of growing mice and to assess the morphological changes in these roots using three-dimensional structural images. Methods We treated 16 12-day-old ICR mice with cyclophosphamide (100 mg/kg, i.p.) and 16 control mice with saline. At 16, 20, 24, and 27 days of age, the mandibular left first molars were scanned using soft micro-computed tomography. After scanning, the structural indices were calculated using a …
T-T cell interactions during cytotoxic T cell responses. IV. Murine lymphoid dendritic cells are powerful stimulators for helper T lymphocytes.
1982
Enriched populations of Ia+ Fc receptor-negative dendritic cells were compared to other cell types for their stimulatory activity in primary mixed lymphocyte reactions to alloantigens and 2,4,6,-trinitrophenylated syngeneic cells. Dendritic cells were 20-100 times more effective than unfractionated splenocytes. A second cell type exhibiting strong stimulatory activity was an Ia+ Fc receptor-positive transiently adherent cell. Both types of stimulatory cells were only effective when able to produce the monokine interleukin 1. Thus glutaraldehyde-fixed cells were not stimulatory unless extraneous interleukin 1 was added. Stimulation of helper cells by either dendritic cells or Ia+ Fc receptor…
Phosphine Ligands Based on the Ferrocenyl Platform: Advances in Catalytic Cross-Couplings
2023
Ferrocenyl skeletons tagged with a variety of donor atoms (metalloligands) have become popular in modern metal-catalyzed organic transformations, broadening the applications. Ferrocenylphosphines, such as 1′-bis(diphenylphosphino)ferrocene (dppf), have been widely used as metalloligands in academic and industrial research, motivating further investigation into novel ferrocenylphosphine ligands. The current review concentrated non-exhaustively on emblematic applications of different ferrocenylphosphine ligands in transition metal-catalyzed cross-coupling strategies. Initially, the stereochemical aspects of the ferrocenyl skeleton, nomenclature, and applications of chiral ferrocenyl phosphine…
Two Remarkably Luminous Galaxy Candidates at z ≈ 10-12 Revealed by JWST
2022
The first few 100 Myr at z > 10 mark the last major uncharted epoch in the history of the universe, where only a single galaxy (GN-z11 at z ≈ 11) is currently spectroscopically confirmed. Here we present a search for luminous z > 10 galaxies with JWST/NIRCam photometry spanning ≈1–5 μm and covering 49 arcmin2 from the public JWST Early Release Science programs (CEERS and GLASS). Our most secure candidates are two MUV ≈ −21 systems: GLASS-z12 and GLASS-z10. These galaxies display abrupt ≳1.8 mag breaks in their spectral energy distributions (SEDs), consistent with complete absorption of flux bluewards of Lyα that is redshifted to =+z12.40.3 0.1and=+z10.40.5 0.4. Lower redshift interlopers su…
Cascade complex formation by phosphate in the cobalt(II)/[30]aneN10 anaerobic system
1993
Abstract The interaction of phosphate with the mono- and binuclear cobalt(II) complexes of [30]aneN 10 (1,4,7,10,13,16,19,22,25,28-decaazacyclotriacontane) has been studied by potentiometry in 0.15 mol dm −3 NaClO 4 solution at 298.15 K under anaerobic conditions. The stable species [CoH 2 ([30]aneN 10 )PO 4 ] + , [CoH 4 ([30]aneN 10 )PO 4 ] 3+ , [Co 2 H([30]aneN 10 )PO 4 ] 2+ , [Co 2 H 2 ([30]aneN 10 )PO 4 ] 3+ and [Co 2 H 3 ([30]aneN 10 )PO 4 ] 4+ , where the phosphate anion is directly bound to the metal ions or acts as a second sphere ligand, are formed and their stability constants have been determined. The results obtained allowed for the selection of suitable conditions for the study…
Experimental and theoretical studies on thymine photodimerization mediated by oxidatively generated DNA lesions and epigenetic intermediates.
2020
[EN] Interaction of nucleic acids with light is a scientific question of paramount relevance not only in the understanding of life functioning and evolution, but also in the insurgence of diseases such as malignant skin cancer and in the development of biomarkers and novel light-assisted therapeutic tools. This work shows that the UVA portion of sunlight, not absorbed by canonical DNA nucleobases, can be absorbed by 5-formyluracil (ForU) and 5-formylcytosine (ForC), two ubiquitous oxidatively generated lesions and epigenetic intermediates present in living beings in natural conditions. We measure the strong propensity of these molecules to populate triplet excited states able to transfer th…
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.
2021
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) a…
Coordinated Interpersonal Behaviour in Collective Dance Improvisation: The Aesthetics of Kinaesthetic Togetherness
2018
International audience; Collective dance improvisation (e.g., traditional and social dancing, contact improvisation) is a participatory, relational and embodied art form which eschews standard concepts in aesthetics. We present our ongoing research into the mechanisms underlying the lived experience of "togetherness" associated with such practices. Togetherness in collective dance improvisation is kinaesthetic (based on movement and its perception), and so can be simultaneously addressed from the perspective of the performers and the spectators, and be measured. We utilise these multiple levels of description: the first-person, phenomenological level of personal experiences, the third-perso…
Modulational instability and generation of self-induced transparency solitons in resonant optical fibers
2009
International audience; We consider continuous-wave propagation through a fiber doped with two-level resonant atoms, which is described by a system of nonlinear Schrodinger-Maxwell-Bloch (NLS-MB) equations. We identify the modulational instability (MI) conditions required for the generation of ultrashort pulses, in cases of both anomalous and normal GVD (group-velocity dispersion). It is shown that the self-induced transparency (SIT) induces non-conventional MI sidebands. The main result is a prediction of the existence of both bright and dark SIT solitons in the anomalous and normal GVD regimes.
Protoplanetary Disks, Solar System Minor Bodies and Origin of Life
2001
In the last decade, planetary science researchers have obtained significant advances on the origin and evolution of life on Earth. The increasing resolution and the development of new instruments (as space telescopes and adaptative optics) has provided first detailed images on protoplanetary disks and star formation regions. Moreover, in the last few years, doppler spectroscopic technique has confirmed the presence of extrasolar planets. These evidence shows planetary formation as a continuous and very common process in the Cosmos, indicating that our Solar System is not too special as was suggested in the past.